顺铂-碘化油混悬乳液舌动脉栓塞化疗29例晚期舌鳞癌的疗效评价

目的:评价顺铂-碘化油混悬乳液舌动脉栓塞化疗晚期舌鳞癌的疗效.方法:选取中山大学附属第五医院口腔颌面外科2006年10月至2010年5月间收治的T3、T4期舌鳞癌患者29例,随机分为两组:靶向栓塞化疗组(14例)术前行顺铂舌动脉超选择靶向栓塞化疗;静脉滴注化疗组(15例)术前行顺铂静脉滴注化疗.化疗后2周进行疗效评价,...

Efficacy of Cisplatin-iodized Oil Suspension Emulsions in Lingual Arterial Chemoembolization for 29 Cases of Advanced Squamous Cell Carcinoma of the Tongue

To evaluate clinical effect of cisplatin-iodized oil suspension emulsions in lingual arterial chemoembolization on tongue cancer in advanced stages. Methods: A total of 29 patients with squamous cell carcinoma of the tongue of T3 or T4 stage were randomized into two groups. In the Group A ( 14 cases ), ultraselective intralingual-arterial infusion of cisplatin and iodinated oil resuspending mixture was conducted under guidance of preoperative DSA scan. In Group B ( 15 cases ), intravenous drip infusion of cisplatin was performed. Two weeks after the chemotherapy, the therapeutic efficacy was assessed and surgery or radiotherapy was conducted. Results: Complete response ( CR ) was found in 2 cases of Group A, and partial response ( PR ) was seen in the other 12, without no response ( NR ) or progression of disease ( PD ). Adverse reactions in this group were low fever in 5 cases? and slight nausea in 8 cases. Vomiting, hair loss and overt drop of WBC counts were not found in the group. The amount of bleeding in the surgery of tongue cancer was within 20～30 mL. In group II, PR was seen in 11 of the 15 cases, and NR in 4, without CR or PD. The side effects in the group were as follows: high fever in 10 cases, nausea, vomiting and hair loss in 13 cases, with obvious drop of WBC counts in the patients. The amount of bleeding in the surgery reached at 50～95 mL. There was statistically significant differences in the curative effects and amount of bleedings during the surgery between the two groups ( P < 0.05 ). A 9 to 36-month follow-up in 25 of the patients revealed that one of the patients from Group A died of local recurrence and lymph-node metastasis at 8 months after surgery, and another one died of pulmonary metastasis at 6 months after radiotherapy. Three patients from Group B succumbed to the local recurrence. Conclusion: There are satisfactory curative effects and few adverse reactions in the patients with advanced squamous cell carcinoma of the tongue after preoperative DSA-guided ultraselective intralingual-arterial infusion of cisplatin and iodinated oil resuspended mixture, which is worthy of popularizing in clinical practice.