| Possible involvement of the opioid receptor gene expression in the mechanisms of the analgesic action of melatonin |
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| 作者姓名： | Li Shu - hui Li Xiao - hui Hu De - yao Wang Zheng - guo |
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| 作者单位： | [1]Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, People＇s Republic of China [2]Faculty of Basic Medicine, Third Military Medical University, Chongqing 40003 |
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| 摘 要： | In the present study, we attempt to analyse the potential involvement of the opioid receptor gene expression in the mechanisms of the analgesic action of melatonin. A trauma-pain model was established in Wistar rats by combining right - hind limb amputation with 50℃ tail - flick test. Antinociception was determined by tail-flick latency to hot waster at 50℃. Melatonin produced the antinociceptive effect in dose-dependent manner after i. p or i. c.v. administration Injected i. c. v. to rats, naloxone（10μg） obviously antagonized the antinociceptive effect induced by i.p. melatonin.
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| 关 键 词： | 基因表达 止痛剂 褪黑激素 药理作用 |
Possible involvement of the opioid receptor gene expression in the mechanisms of the analgesic action of melatonin |
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| Authors: | Li;Shu;-;hui;Li;Xiao;-;hui;Hu;De;-;yao;Wang;Zheng;-;guo |
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| Abstract: | |
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| Keywords: | Melatonin Antinociceptive mechanism MIOR mRNA KOR mRNA Tail-flick latency Limb amputation |
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