卡维地洛对正常青年男性Q-T间期离散度的影响

目的探讨健康男性青年服用β受体阻滞剂卡维地洛后不同血药浓度下静息心电图QT间期离散度（QTd）与用药前比较有无显著性变化,以对卡维地洛的抗心律失常作用机制提供依据。方法对20名健康男青年在服用卡维地洛20 mg前及服药后0.5、1、2、3、4、6、8、10、24 h分别测血药浓度,并做静息心电图,于十二导联心电图测量Q-T间期离散度。并将数据进行统计分析。结果随着血药浓度的升高,QTd有缩小趋势,但与用药前比较各P值无显著性差异。结论卡维地洛对正常健康男性的QTd可能无影响,从反面证实,它主要对有病理情况下的心脏病患者有抗心律失常作用。

The Influence of carvedilol on QTd of young men in good health

Objective To investigate the effects of carvedilol on QTd changes,and to provide some evi-dence of carvedilol in clinical antiarrhythmic mechanisms.Methods Abstract randomly20 healthy young men.Everyone was asked to take 20 mgcarvedilol.Their QTd duringresttime of EKGwere measured before and aftertaking the drug,respectively at0.5 h,1 h,2 h,3h,4 h,6 h,8 h,10 h,24 h.Meantime their drug blood concen-trations were measured atdifferenttime point.Results The higher the drugblood concentrations go,the smallerthe QTd were,but there are no significant differences between thePvalue before and after administration.Con-clusion Carvedilol has probably no influence on QTd of yong men in good health.It indicates that carvedilolhas antiarrhythic use for patients with pathologic conditions.