| 滇桂艾纳香不同提取物急性毒性研究 |
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| 引用本文： | 姜建萍,刘喜华,杜秀,陈晨.滇桂艾纳香不同提取物急性毒性研究[J].华夏医学,2009,22(5):808-810. |
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| 作者姓名： | 姜建萍 刘喜华 杜秀 陈晨 |
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| 作者单位： | 广西中医学院,广西南宁,530001 |
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| 摘 要： | 目的：观察滇桂艾纳香药材用不同溶剂提取的浸膏灌胃给予小鼠后产生的急性毒性反应和死亡情况。方法：预实验发现50%、70%乙醇提取物毒性不明显,无法测定半数致死量（LD50）,需改作最大耐受量（MTD）试验,并且初步确定水提取物半数致死量（LD50）试验用药剂量,正式实验采用小鼠灌胃给药的方法测定水提取物半数致死量（LD50）和50%、70%乙醇提取物最大耐受量（MTD）。结果：滇桂艾纳香水提取物的LD50为143.1034g生药/kg,50%、70%乙醇提取物MTD分别259.60g生药/kg、309.68g生药/kg。结论：滇桂艾纳香毒性较小,临床用药安全,且水提取物毒性大于醇提取物。
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| 关 键 词： | 滇桂艾纳香 提取物 急性毒性 |
The test of acute toxicity on different Blumea riparia(Bl.)DC extract |
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| JIANG Jian-ping,LIU Xi-hua,DU Xiu,et al..The test of acute toxicity on different Blumea riparia(Bl.)DC extract[J].Acta Medicinae Sinica,2009,22(5):808-810. |
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| Authors: | JIANG Jian-ping LIU Xi-hua DU Xiu |
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| Affiliation: | JIANG Jian-ping,LIU Xi-hua,DU Xiu,et al.Guangxi Traditional Chinese Medical University,Nanning 530001,China |
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| Abstract: | Objective:To observe the acute toxicity and the death status of different solvent extracts of Blumea riparia(Bl)DC.by ig in mice.Methods:The pre-experiment shows that 50% and 70% alcohol extracts can't determine LD50 which have no obvious toxic effect,so it is necessary to change it with the maximum tolerated dose(MTD)experiment.And the aqueous extract of LD50 of medicine dose is initially difined.The official test determines the aqueous extract of LD50,50% and 70% alcohol extracts of MTD by ig administrati... |
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| Keywords: | Blumea riparia(Bl)DC extract acute toxicity |
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