| 基于异常黑胆质证载体大鼠模型尿液代谢组学研究 |
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| 引用本文： | 阿衣古丽·玉努斯,哈木拉提·吾甫尔,帕丽旦·麦麦提,阿布力孜·阿卜杜扎依尔,甫拉提·吐尔逊,库热西·玉努斯.基于异常黑胆质证载体大鼠模型尿液代谢组学研究[J].新疆医科大学学报,2012,35(6):732-735,739. |
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| 作者姓名： | 阿衣古丽·玉努斯 哈木拉提·吾甫尔 帕丽旦·麦麦提 阿布力孜·阿卜杜扎依尔 甫拉提·吐尔逊 库热西·玉努斯 |
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| 作者单位： | 1. 新疆医科大学,第二附属医院药剂科, 乌鲁木齐 830011
2. 新疆医科大学,新疆维吾尔自治区地方病分子生物学实验室, 乌鲁木齐 830011 |
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| 摘 要： | 目的探讨异常黑胆质证对大鼠尿液代谢谱的影响。方法在建立异常黑胆质证大鼠模型的基础上,运用代谢组学研究技术,对异常黑胆质证组(17只)及正常对照组(13只)大鼠尿液进行核磁共振氢谱检测,确定两组大鼠尿液中的差异代谢组分。结果与正常对照组相比,异常黑胆质证组大鼠尿液中胍基乙酸、肌酸酐、蛋氨酸、赖氨酸及色氨酸含量升高,苯丙氨酸、天冬氨酸的含量下降(P<0.05)。结论正常对照组与异常黑胆质证组大鼠尿液的代谢谱存在差异,异常黑胆质证大鼠存在糖、脂肪、蛋白质及磷酸肌酸代谢紊乱。
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| 关 键 词： | 维吾尔医学 异常黑胆质 代谢组学 |
Urine metabolomics studies of abnormal savda syndrome rat model |
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| Ayiguli Yunusi
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Hamurat Upur
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Palidan Maimait
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Abulizi Abuduzhayier
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Pulati Tuerxun
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Kurexi Yunusi.Urine metabolomics studies of abnormal savda syndrome rat model[J].Journal of Xinjiang Medical University,2012,35(6):732-735,739. |
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| Authors: | Ayiguli Yunusi Hamurat Upur Palidan Maimait Abulizi Abuduzhayier Pulati Tuerxun Kurexi Yunusi |
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| Affiliation: | Ayiguli Yunusi1,Hamurat Upur2,Palidan Maimait2,Abulizi Abuduzhayier2, Pulati Tuerxun2,Kurexi Yunusi2(1The Second A f filiated Hospital Pharmacy,Xinjiang Medical University, 2Autonomous Region Local Disease Molecular Biology Laboratory,Urumqi 830011,China) |
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| Abstract: | Objective To investigate metabolites content variation in occurrence and development of Abnormal savda syndrome.Methods Based on establishing abnormal savda syndrome rat model,A 1H NMR based metabolomic analysis was performed on urine of abnormal savda syndrome rat model groups and control groups to identify differential metabolites.Results Compared with the normal control group,urine guanidinoacetic acid,creatinine,methionine,lysine and tryptophan content increased,phenylalanine,aspartic acid content decreased in the abnormal savda syndrome rats(P<0.05).Conclusion Normal and abnormal savda syndrome rats urine metabolic profiles exist difference,abnormal savda syndrome rat presence of sugar,fat,protein and creatine phosphate metabolism disorders. |
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| Keywords: | Traditional Uyghur Medicine abnormal savda metabolomics |
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