Evolution of neuropsychological profile in motor subtypes of multiple system atrophy |
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| Affiliation: | 1. Department of Neurology, Kyungpook National University Hospital, Daegu, South Korea;2. Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea;3. Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea;4. Department of Neurology, Dongsan Medical Center, Keimyung University, Daegu, South Korea;5. Department of Neurology, Bobath Memorial Hospital, Seongnam, South Korea;6. Department of Neurology, Best Heals Hospital, Ansan, South Korea;7. Department of Neurology, Metro Hospital, Anyang, South Korea;8. Department of Neurology, The Good Light Hospital, Gwangju, South Korea |
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| Abstract: | IntroductionCognitive deficits and neuropsychiatric symptoms occur in parkinsonian and cerebellar subtypes of Multiple System Atrophy (MSA-P and MSA-C). These symptoms have been investigated mainly in cross-sectional studies. The present 1-year follow-up study aimed at evaluating the evolution of cognitive and neuropsychiatric profile in patients with MSA-C and MSA-P.MethodsTwenty-nine patients with MSA-P, 21 with MSA-C and 30 healthy subjects (HCs) underwent a neuropsychological battery and questionnaires assessing depression and apathy (T0). After 1 year (T1), patients with MSA-C and MSA-P underwent the same neuropsychological and neuropsychiatric tools employed at T0.ResultsAt T0, MSA-P and MSA-C groups were more depressed and apathetic and performed worse on tests assessing repetition abilities, executive and attentive functions than HCs. MSA-P and MSA-C groups did not differ on cognitive variables and neuropsychiatric scales. At T1, a significant worsening in spatial planning and psychomotor speed in MSA-C group and a significant worsening in memory, spatial planning, repetition abilities and functional autonomy in MSA-P group were found. The prevalence of apathy increased in both subtypes, whereas the prevalence of depression was reduced in MSA-C and relatively consistent in MSA-P.ConclusionsThe finding revealed a wide-ranging worsening of cognitive functions in MSA-P and a significant decline in processing speed in MSA-C. These results underline the relevance of evaluating cognitive and psychiatric features of MSA over the course of the disease in the daily clinical practice. |
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| Keywords: | Multiple system atrophy Cognitive deficits Depression Apathy |
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