Abnormal development pattern of the amygdala and hippocampus from childhood to adulthood with autism |
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| Affiliation: | 1. State Key Laboratory of Cognitive Neuroscience and Learning , Beijing Normal University, Beijing, China;2. Jiangsu Provincial Key Laboratory of Special Children’s Impairment and Intervention, Nanjing Normal University of Special Education, Nanjing, China;3. College of Educational Science, Anhui Normal University, Wuhu, Anhui, China;4. No.2 Middle School of Tianzhu, Guizhou, China;5. School of Education, Ningxia University, Yinchuan, China;1. San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, California;2. Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, San Diego, California;1. Department of Psychology, University of New Mexico, Albuquerque, New Mexico;2. Psychology Clinical Neuroscience Center, University of New Mexico, Albuquerque, New Mexico;3. Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California;4. MIND Institute, University of California, Davis, Davis, California;5. Imaging Research Center, University of California, Davis, Davis, California;6. Center for Cognitive Neuroscience, Duke University, Durham, North Carolina;1. School of Computer Engineering and Science, Shanghai University, Shanghai 200072, China;2. South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, China;3. Key Lab for Behavioral Economic Science and Technology, South China Normal University, Guangzhou, China;1. Bucknell University, Program in Neuroscience, Lewisburg, PA 17837, United States;2. Autism and Developmental Medicine Institute, Geisinger Health System, Lewisburg, PA 17837, United States;3. Olga Tennison Autism Research Centre, Cooperative Research Centre for Living with Autism (Autism CRC), School of Psychology and Public Health, La Trobe University, Victoria 3086, Australia;4. Department of Radiology, Geisinger Health Systems, Danville, PA 17821, United States;5. Institute for Advanced Application, Geisinger Health Systems, Danville, PA 17821, United States;1. Department of Rehabilitation Sciences, Group Biomedical Sciences, Neuromotor Rehabilitation Research Group, University of Leuven, Katholieke Universiteit Leuven, Belgium;2. Department of Chronic Diseases, Metabolism and Ageing, Group Biomedical Sciences, Pneumology Research Group, University of Leuven, Katholieke Universiteit Leuven, Belgium;3. Department of Health Sciences and Technology, Neural Control of Movement Lab, Eidgenössische Technische Hochschule, Zurich, Switzerland |
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| Abstract: | Using magnetic resonance imaging to determine neuropathology in autism spectrum disorders, we report findings on the volume of the amygdala and hippocampus in autistic children. The volumes of amygdala, hippocampus and total brain were obtained by volbrain and their volumes were measured in young people (6.5–27.0 years of age) that comes from ABIDE dataset. Although there was no significant difference in total brain capacity between groups, autistic children (6.5–12.0 years of age) had larger right and left absolute and relative amygdala volumes than the control group. There was no difference in amygdala volume between adolescence (13–19 years old) and adults (20–27 years old). Interestingly, the volume of the amygdala in typical developing children increased significantly from 6.5 to 27 years of age. Thus, amygdala in children with autism was initially small, but no age-related increases were observed in normal developing children. The right absolute hippocampal volume of autistic patients was also larger than that of normal adults, but not after controlling the total brain volume. These cross-sectional findings suggest that abnormal patterns of hippocampal and amygdala development continue into adolescence in autistic patients. |
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| Keywords: | Autism Age Hippocampus Amygdala |
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