| Effect of HIF-1α on VEGF-C Induced Lymphangiogenesis and Lymph Nodes Metastases of Pancreatic Cancer |
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| 引用本文： | 陶京,李弢,李凯,熊炯炘,杨智勇,吴河水,王春友.Effect of HIF-1α on VEGF-C Induced Lymphangiogenesis and Lymph Nodes Metastases of Pancreatic Cancer[J].华中科技大学学报(医学英德文版),2006,26(5):562-564. |
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| 作者姓名： | 陶京 李弢 李凯 熊炯炘 杨智勇 吴河水 王春友 |
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| 作者单位： | Department of Pancreatic Surgery Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China，Department of Nephrology，Wuhan Children Hospital，Wuhan 430016，China，Department of Pancreatic Surgery，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China，Department of Pancreatic Surgery，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China，Department of Pancreatic Surgery，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China，Department of Pancreatic Surgery，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China，Department of Pancreatic Surgery，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430022，China |
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| 基金项目： | This project was supported by grants from Hubei Provincial Natural Sciences Foundation of China (No. 2006ABA126)
Key Science-Technology Project of Hubei Province (No. 2006AA301C30). |
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| 摘 要： | The effect of hypoxia inducible factor-1α(HIF-1α) on vascular endothelial growth factor C (VEGF-C) and the correlation between HIF-1αand lymphangiogenesis and lymph nodes metasta-ses (LNM) in pancreatic cancer were investigated. Immunohistochemical SP method was used to detect the protein expression of HIF-1αand VEGF-C, and Lymphatic vessel density (LVD) was determined by stain of VEGFR-3, collagen type IV in 75 pancreatic head cancers from regional pancre-atectomy (RP) during Dec. 2001 to Dec. 2003. The relationship between HIF-1αand VEGF-C, lymphangiogenesis, LNM was analyzed statistically. The results showed that the positive expression rate of HIF-1αand VEGF-C in pancreatic cancer tissues was 48.00 % (36/75) and 65.33 % (49/75) respectively. In positive group of HIF-1α, the positive rate of VEGF-C and LVD, and LVD rate was 80.56 % (29/36), 13.22±3.76 and 88.89 % (32/36) respectively, and in negative group of HEF-1α, positive rate of VEGF-C and LVD was 51.28 % (20/39), 5.98±2.17 and 66.67 % (26/39) respectively (P<0.01 or P<0.05). It was suggested that HIF-1αcould promote the expression of VEGF-C, lymphangiogenesis and LNM in pancreatic cancer.
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| 关 键 词： | 胰腺癌 缺血 病理 治疗 |
| 收稿时间： | 2006-03-15 |
Effect of HIF-1α on VEGF-C induced lymphangiogenesis and lymph nodes metastases of pancreatic cancer |
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| Jing Tao M.D., Ph.D.,Tao Li,Kai Li,Jiongxin Xiong,Zhiyong Yang,Heshui Wu,Chunyou Wang.Effect of HIF-1α on VEGF-C induced lymphangiogenesis and lymph nodes metastases of pancreatic cancer[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2006,26(5):562-564. |
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| Authors: | Jing Tao MD PhD Tao Li Kai Li Jiongxin Xiong Zhiyong Yang Heshui Wu Chunyou Wang |
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| Affiliation: | (1) Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China;(2) Department of Nephrology, Wuhan Children Hospital, Wuhan, 430016, China |
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| Abstract: | Summary The effect of hypoxia inducible factor-1α (HIF-1α) on vascular endothelial growth factor C (VEGF-C) and the correlation between
HIF-1α and lymphangiogenesis and lymph nodes metastases (LNM) in pancreatic cancer were investigated. Immunohistochemical
SP method was used to detect the protein expression of HIF-1α and VEGF-C, and Lymphatic vessel density (LVD) was determined
by stain of VEGFR-3, collagen type IV in 75 pancreatic head cancers from regional pancreatectomy (RP) during Dec. 2001 to
Dec. 2003. The relationship between HIF-1α and VEGF-C, lymphangiogenesis, LNM was analyzed statistically. The results showed
that the positive expression rate of HIF-1α and VEGF-C in pancreatic cancer tissues was 48.00 % (36/75) and 65.33 % (49/75)
respectively. In positive group of HIF-1α, the positive rate of VEGF-C and LVD, and LVD rate was 80.56 % (29/36), 13.22±3.76
and 88.89 % (32/36) respectively, and in negative group of HIF-1α, positive rate of VEGF-C and LVD was 51.28 % (20/39), 5.98±2.17
and 66.67 % (26/39) respectively (P<0.01 or P<0.05). It was suggested that HIF-1α could promote the expression of VEGF-C, lymphangiogenesis and LNM in pancreatic cancer.
This project was supported by grants from Hubei Provincial Natural Sciences Foundation of China (No. 2006ABA126) and Key Science-Technology
Project of Hubei Province (No. 2006AA301C30). |
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| Keywords: | pancreatic adenocarcinoma hypoxia inducible factor-la vascular endothelial growth factor C lymphangiogenesis lymph nodes metastases |
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