舒经汤治疗痛经及对患者血液流变学的影响

目的探讨舒经汤治疗原发性痛经的疗效及安全性。方法将62例原发性痛经患者随机分为3组,其中治疗组21例(口服舒经汤)、中药对照组21例(口服痛经宝颗粒)、西药对照组20例(口服双氯芬酸),观察各组的临床疗效、血液流变学变化及不良反应。结果治疗组、中药对照组及西药对照组的总有效率分别为95.2%、90.5%及77.8%。治疗前治疗组的血浆粘度(1.60±0.23)mPa·s,纤维蛋白原(4.40±1.18)g/L,均值略高于健康组,其中血沉均值与健康组比有非常显著差异(P<0.01)。而治疗后血浆粘度(1.34±0.18)mPa·s,纤维蛋白原(3.32±1.27)g/L,均值与健康组比无差异,其中血沉与健康组比较无显著性差异(P>0.05)。治疗组和中药对照组均未见明显不良反应,西药对照组主要表现为消化道反应。结论舒经汤治疗原发性痛经疗效确定,且远期疗效及安全性均优于西药对照组。     

Behavioral treatment parameters with primary dysmenorrhea

Fourteen women with primary dysmenorrhea were administered four sessions of systematic desensitization (SD) by either a male or a female therapist. The following measures were taken during the flow periods before and after treatment and at a 6-month follow-up: menstrual symptom checklist, medication usage, invalid hours, and menstrual attitudes. At pretreatment, menstrually distressed women had significantly higher scores on all measures compared to a normative group and an explicitly nondistressed group. At posttreatment, treated women's scores on the dependent variables were significantly reduced. All indices were reduced to a nondistressed level at posttreatment and at 6-month follow-up. Type of dysmenorrhea (congestive vs. spasmodic), trait anxiety level, and therapist sex did not predict differential responsiveness to SD. SD did not affect frontalis EMG, peripheral blood flow, or pain threshold. A Retrospective Symptom Scale of menstrual distress was found to be highly reliable, valid, and sensitive.     

针灸治疗原发性痛经68例临床观察

采用针刺配隔姜灸治疗原发性痛经 6 8例 ,总有效率 97.0 6 % ,与药物对照组相比 ,P<0 .0 1 ,说明针灸治疗组疗效明显优于药物对照组     

634名女大学生痛经情况调查分析

目的 了解原发性痛经在高校女生中的发生情况及其相关因素。方法 采用调查表和妇科问诊两种方法对６３４名在校女大学生进行调查分析。结果 原发性痛经的发生率为３１．５５％。结论 情绪变化是痛经的主要诱发因素。     

经络输声疗法对原发性痛经的经络调整作用

本文以月经相关经脉的声传导的变化为观察指标，通过经络输声疗法对８２例原发性痛经治疗效果的观察，以验证经络输声疗法对经络的调整作用。将８２例原发性痛经随机分为３组，分别用３个频率治疗，进行对比分析。临床结果表明：经３个月经周期的治疗，痛经症状积分明显下降；月经血色、血量、血块趋于正常；总有效率为９６．４３％；对虚实证均有效，但其输声频率的选择有差异。说明经络输声疗法对经络有疏通、调节作用。实验结果表明：经络输声能改变原发性痛经相关经脉的声传导状态，治疗后经络导声恢复正常，证实了经络输声对经络的调整作用。从客观上显示了有关经络的病理及愈复变化。此项研究国内外尚无报道。     

加味佛手散对原发性痛经模型大鼠血清雌二醇和孕酮浓度的影响

目的：探讨加味佛手散（AFSS）对原发性痛经模型大鼠血清雌二醇（E2）和孕酮（P）浓度的影响。方法 SD大鼠60只,按体质量分层随机法分为正常对照组,模型组、AFSS低、中、高剂量组,元胡止痛片组,阳性对照组各10只。造模第6天起,在注射己烯雌酚的同时,AFSS低剂量组给予AFSS 0.75 g/kg、中剂量组给予AFSS 1.5 g/kg、高剂量组给予AFSS 3.0 g/kg,元胡止痛片组给予1.0 g/kg灌胃,给药容积为5 ml/kg;正常对照组、模型组同体积蒸馏水灌胃,连续7 d。采用ELISA法检测大鼠血清中 E2、P 水平,计算 E/P 比值。结果 AFSS 中、高剂量组血清中 E2含量[（48.27±6.42）pg/L、（47.51±7.03）pg/L]低于模型组（54.47±9.12）pg/L,P＜0.05;AFSS低剂量组E2含量（50.83±6.26）pg/L,与模型组比较差异无统计学意义（P＞0.05）;AFSS 各剂量组 P 含量分别为（687.41±21.14）ng/L、（720.47±41.03）ng/L、（719.78±32.01）ng/L,均高于模型组（667.32±46.51）ng/L（P＜0.05或0.01）;AFSS中、高剂量组P含量高于元胡止痛片组（699.31±36.31）ng/L（P＜0.05）。结论 AFSS中、高剂量组可降低E2、提高P含量、降低E2/P比值。     

基于现代文献分析针刺治疗原发性痛经辨证选穴的规律

目的基于现代文献分析针刺治疗原发性痛经辨证选穴的用穴规律。方法系统检索中国知网、万方数据知识服务平台、维普数据库自建库至2018年10月20日的针刺治疗原发性痛经辨证选穴的相关文献,将文献导入Note express软件进行查重,根据纳入、排除标准进行选择,建立Excel工作表对将最终纳入文献的年份、文题、文章类型、辨证分型、各证型针刺选穴等信息进行提取,同时对文献中证型名称、腧穴名称进行规范化管理,并运用SPSS 20.0统计软件进行频次、频率分析。结果(1)共检索到1656篇文献,纳入46篇,共涉及64个穴位,11种证型。(2)11种证型分为实证、虚证2类,其中实证用穴59个、虚证用穴46个。实证选穴使用频次位居前5位的是三阴交、关元、次髎、地机、太冲;虚证选穴使用频次位居前5位的是足三里、三阴交、关元、次髎、肾俞。对所有实证、虚证选穴的所属经脉分别进行统计,实证前5条经脉依次是足太阴脾经、任脉、足太阳膀胱经、足厥阴肝经、足阳明胃经;虚证前5条经脉依次是足太阳膀胱经、任脉、足太阴脾经、足阳明胃经、足少阴肾经。(3)11种证型根据出现频次高低依次为气滞血瘀证、寒湿阻滞证、气血两虚证、肝肾亏虚证、寒凝血瘀证、肝郁气滞证、湿热瘀阻证、肝郁湿热证、肾气亏虚证、寒凝证、胞宫虚寒证;以上证型使用频次位居前5位的依次是三阴交、关元、次髎、地机、太冲。同时各证型具体选穴又有所不同,其中前5个证型其使用频次位居前5位的穴位分别如下,气滞血瘀证:太冲、三阴交、关元、次髎、地机;寒湿阻滞证:三阴交、关元、地机、次髎、中极;气血两虚证:足三里、三阴交、关元、气海、次髎;肝肾亏虚证:肾俞、三阴交、关元、肝俞、足三里;寒凝血瘀证:关元、三阴交、次髎、中极、肾俞。结论针刺治疗原发性痛经总体选穴以阴经穴位为主,多选用足太阴脾经、任脉腧穴。辨证分型以气滞血瘀证最为多见,各证型间、实证和虚证间具体选穴有所不同,均体现了辨证选穴。     

以地机为主穴针刺治疗原发性痛经30例

目的观察以地机为主穴治疗原发性痛经的临床疗效。方法将60例患者随机分为治疗组（30例）和对照组（30例）,治疗组以地机穴为主穴结合辨证取穴治疗,对照组口服布洛芬;两组均连续3个月经周期为1个疗程,观察症状体征积分变化情况,疗程结束3个月后统计临床疗效。结果治疗组、对照组总有效率分别为96．7％、70．0％;组间临床疗效比较,差异有统计学意义（P〈0．05）。两组治疗后症状体征积分均明显减少（P〈0．05）;组间治疗后及差值比较,差异均有统计学意义（P〈0．05）。结论以地机穴为主穴针刺治疗原发性痛经疗效良好。     

Cover Image,Volume 80, Issue 3

Primary dysmenorrhea affects the quality of life in young women, particularly school and work performance. This study investigated the mechanisms of penehyclidine hydrochloride (PHC) efficacy on a rat model of primary dysmenorrhea. The model was induced by injecting both estradiol benzoate and oxytocin. Different doses of PHC were administrated intraperitoneally following estradiol benzoate administration. Writhing scores were assessed, and pathological changes of the uterus were observed via hematoxylin and eosin staining. Western blot and real-time PCR were used to evaluate the expression level of the M₃ receptor, both TLR₃ and TLR₄ in uterine tissue, and the level of Ca²⁺ was measured in uterine tissues. Writhing scores significantly decreased in the PHC treatment group compared to model, and PHC alleviated the occurrence of edema or necrosis in the uteri compared to model group. PHC can decrease the M₃ receptor, TLR₃, TLR₄ expression, and the Ca²⁺ level compared to the model group. PHC is a potential candidate for the future treatment of primary dysmenorrhea due to its ability to attenuate muscarinic receptors and TLRs.