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1.
目的:探讨复方甲硝唑栓联合结合雌激素软膏治疗老年性阴道炎的临床疗效及对患者血清激素水平的影响。方法:截选2012年2月至2014年10月80例老年性阴道炎患者,按照随机数字表法分为对照组(甲硝唑栓)与观察组(复方甲硝唑栓联合结合雌激素软膏),各40例;观察两组患者治疗前后临床症状及性激素水平变化、临床疗效及不良反应,随访3个月,统计两组治愈患者复发情况。结果:治疗后,两组患者临床症状、E_2、FSH水平均较治疗前明显改善,且观察组诸项指标均优于对照组(P0.05);观察组临床治疗总有效率为97.5%,明显高于对照组的65.0%(P0.05);两组患者不良反应率无显著差异(P0.05);随访3个月,观察组复发率明显低于对照组(P0.05)。结论:应用复方甲硝唑栓联合结合雌激素软膏治疗老年性阴道炎疗效显著且稳定。  相似文献   
2.
背景:以往研究发现雪蛤具有预防绝经后相关疾病的作用,但是否具有预防绝经后骨质疏松的功效有待于深入研究。 目的:验证雪蛤酶解液对去卵巢大鼠骨质疏松的预防作用。 方法:健康成年Wistar大鼠72只,按随机数字表法分为6组,每组12只。假手术组大鼠不切除卵巢仅切除卵巢周围部分脂肪,其余各组均切除卵巢造成骨质疏松模型。于造模后第7天开始,各组等容灌胃,连续12周。假手术组和模型组每日灌胃等量蒸馏水;普雷马林组每日灌胃387.8 g/L普雷马林(结合雌激素片)悬浮液6. 67 g/(kg•d);67.0,26.8,13.4 g/(kg•d) 蛤士蟆酶解液组每日分别按相应剂量灌胃。每个月测定食物利用率;实验12周末时,处死大鼠后取子宫,测定子宫质量;取左、右侧股骨和腰椎骨,双能X射线骨密度仪测定骨密度;电感偶合等离子体直读光谱仪测定骨钙、磷含量;脱脂、灰化后测定骨干质量、灰质量。 结果与结论:在4组干预组中,67.0 g/(kg•d)蛤士蟆酶解液组和普雷马林组的食物利用率最低(P < 0.05);在各切卵巢组中,普雷马林组的子宫质量最重(P < 0.05);26.8 g/(kg•d) 蛤士蟆酶解液和普雷马林可以延缓切卵巢大鼠股骨骨密度的下降(P < 0.05);67.0,26.8,13.4 g/(kg•d)蛤士蟆酶解液组骨钙和骨磷与模型组比较均有明显提升(P < 0.05),与普雷马林组差异无显著性意义(P > 0.05)。提示雪蛤酶解液对去卵巢大鼠的骨质疏松具有预防作用,其疗效与结合雌激素片相当,且对子宫增生的不良反应低于结合雌激素片。  相似文献   
3.
Summary

A double-blind, randomized study was carried out in 43 women, who had undergone spontaneous ménopause at least 6 months earlier, to compare the effectiveness and tolerance of veralipride with that of a conjugated oestrogens preparation in the control of hot flushes. Twenty-one women received 100?mg veralipride per da-v and 22 were due to receive 1.25?mg per day of the hormone preparation over a period of 20 days but 3 women in the oestrogen group discontinued the trial without giving any reason. The number, duration and severity of hot flushes were assessed and scored at the start of the trial and during treatment. Statistical analysis of the results showed marked relief with both preparations but no significant difference between them in terms of effectiveness or tolerance. Veralipride, however, appeared to provide better control in patients who had complained of severe hot flushes initially.  相似文献   
4.
目的研究妇科养荣丸治疗抗精神病药所致闭经泌乳综合征疗效及性激素水平的影响。方法选择女性符合诊断标准首发精神分裂症的闭经泌乳综合征患者60例,分为对照组与治疗组各30例;分别采用倍美力+黄体酮胶囊人工周期疗法和妇科养荣丸;疗程均为4个月;观察其疗效及性激素(E_2、FSH、LH、P)水平的变化,并进行统计分析。结果两组总有效率相同(P〉0.05);治疗组性激素水平明显改善(P〈0.05),对照组无明显改变(P〉0.05);治疗组副作用发生率低于对照组(P〈0.05)。结论妇科养荣丸治疗抗精神病药所致闭经泌乳综合征可明显改善患者性激素水平。效果显著。  相似文献   
5.
6.
目的观察倍美力软膏对卵巢切除术后萎缩性阴道炎的临床疗效。方法10例卵巢切除术后萎缩性阴道炎患者采用倍美力软膏阴道给药,使用前后进行阴道评分以评估疗效。结果用药后阴道炎症状评分明显下降,阴道健康评分显著提高,差异均有统计学意义(P〈0.01),患者均无不良反应。结论倍美力阴道软膏治疗卵巢切除术后萎缩性阴道炎安全,有效。  相似文献   
7.
去氧孕烯炔雌醇治疗青春期功血的疗效分析   总被引:12,自引:0,他引:12  
目的观察去氧孕烯炔雌醇(俗称妈富隆)与结合雌激素(俗称倍美力)治疗青春期功能失调性子宫出血(功血)的止血效果。方法对122例青春期功血合并中重度贫血患者的临床资料进行回顾性分析,其中采用倍美力治疗62例为倍美力组,口服妈富隆治疗60例为妈富隆组,观察两组患者的临床疗效并进行对比。结果妈富隆组全部止血成功,倍美力组6例失败;妈富隆组控制出血时间及完全止血时间明显短于倍美力组(P〈0.01)。结论妈富隆治疗青春期功血疗效明显优于传统的雌激素治疗方案。  相似文献   
8.
Sixty-three healthy post-menopausal women participated in the study aimed at determining the efficiency of percutaneous administration of estradiol (E2) giving physiological plasma levels of the estrogen to provide an efficient relief of climacteric and urogenital symptoms. Among these women, 31 had previous hysterectomy and were randomly allocated to one of the two estrogen replacement therapies while, similarly, the 32 women having an uterus were randomly divided between two groups who received in addition to estrogens, micronized oral progesterone. As estrogen, women received either E2 by percutaneous administration (Oestrogel) or oral conjugated estrogens (Premarin). With Oestrogel, serum E2 and estrone levels were within those seen during premenopause and showed a ratio close to 1.0. Climacteric symptoms were reduced or eliminated similarly in all groups. No change was noticed on the concentration of serum angiotensinogen with Oestrogel therapy while a 2.5-fold increase was found in women receiving Premarin. As indicated by the 24-week endometrial biopsy, the progestational response induced by oral progesterone at the dose used was sufficient in twenty out of thirty-two women to cause endometrial atrophy, thus suggesting the need for higher amounts of micronized progesterone in a proportion of women. The present data also indicate that Oestrogel provides efficient relief of climacteric and urogenital symptoms without exerting any detectable effect on hepatic function while maintaining the ratio of serum E2/E1 at the physiological value of 1.0.  相似文献   
9.
Intravenous injection of physiological saline, sigetin, and Premarin into rats on the 16th day of pregnancy had a marked effect on permeability of the placenta after blood loss.Laboratory of Normal and Pathological Physiology, Institute of Obstetrics and Gynecology, Academy of Medical Sciences of the USSR, Leningrad. (Presented by Academician of the Academy of Medical Sciences of the USSR O. V. Baroyan.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 8, pp. 164–165, August, 1977.  相似文献   
10.
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