Successful treatment of proton pump inhibitor induced sporadic fundic gland polyps with an argon plasma coagulator in a patient with polycythaemia vera

IntroductionProton pump inhibitor (PPI) use is associated with the development of fundic gland polyps (FGPs); discontinuing PPIs is associated with regression of FGPs. Here, we report a rare case of non-respondent FGPs after discontinuation of PPI that were successfully treated using an argon plasma coagulator (APC).Presentation of caseWe present the case of a 68-year-old woman with a history of polycytheamia vera. She also had gastroesophageal reflux disease (GERD) and had been taking 10 mg of omeprazole daily for the past three years. Esophagogastroduedenoscopy (GF) revealed over 100 pedunculated polyps in the gastric body and fundus. Histological examination of the specimens showed dilated oxyntic glands with flattened parietal and mucous cells. Based on these findings and the clinical history, a diagnosis of FGPs was made. Omeprazole use was then discontinued. Repeat GF performed 6 months and 1 year later showed a significant increase in the number and size of the polyps. APC treatment was performed every 6 months for 3 years. Further GF showed a significant decrease in the number and size of the FGPs 4 years after discontinuing PPI.DiscussionWe conclude that PPI use is a strong risk factor for the development of FGPs and discontinuing PPI is associated with regression of FGPs, but not in patients with polycythaemia vera. However, the mechanism involved in the interaction between FGP and polycytheamia vera remains unknown.ConclusionNon-respondent FGPs after discontinuation of PPI use may be successfully treated using APC.     

新生牛肝提取物生物学活性分析

复肝肽（FGP）系采用膜法提取技术,从新生牛肝脏中提取制备出的生物活性物质。测定其多肽的含量为950．03mg／100ml。本实验对其促生长、免疫增强作用、对化学性肝损伤辅助保护作用等生物学活性进行了研究。结果表明：小鼠体重较对照组有增加趋势（P〉0．05）;腹腔注射2．5、5．0、10．0ml／（kg·bw）复肝肽组小鼠玫瑰花环成环率分别高于对照组（生理盐水）33．3％,34．2％,39．6％,差异显著（P〈0．05）。注射10．0ml／（kg·bw）复肝肽的小鼠血清溶血素OD值与对照组差异显著（P〈0．01）。剂量组小鼠腹腔巨噬细胞吞噬百分率分别比对照组高22．1％,25．8％,26．5％,差异均有显著性（P〈0．05或P〈0．01）,说明复肝肽具有免疫增强作用,且呈剂量依赖性。复肝肽5．Oral／（kg·bw）剂量组可有效降低四氯化碳模型小鼠血清中丙氨酸氨基转移酶（ALT）,差异具有显著性（方差分析,P〈0．01）,病理组织学指标亦有明显改善。说明新生牛肝提取物对化学性肝损伤的辅助保护作用。     

银杏叶制剂对脑缺血实验治疗的研究

采用沙士鼠短暂性脑缺血和大鼠局部脑缺血模型，缺血前３０ｍｉｎ按相当于银杏苦内２０ｍｇ／ｋｇ，ｉＰ给药，以观察其对缺血性脑损伤的效应，结果表明：（１）在沙士鼠双侧颈总动脉结扎１０ｍｉｎ再灌４ｄ模型，与对照组相比，银杏叶制剂明显增加海马ＣＡ１区神经元存活数，分别为３８．５０±１６．３１／ｍｍ和１３３．１３１±２０．９９／ｍｍ（Ｐ〈０．０１），与级苯妥英钠组（１６５．４２±２９．６３／ｍｍ）和Ｎｉｍｏｄ     

复肝肽对四氯化碳致小鼠肝损伤的保护作用

目的 探讨复肝肽对四氯化碳(CCl4)引起的小鼠化学性肝损伤的保护作用.方法 将ICR小鼠随机分为5组,1个正常对照组、1个CCl4模型对照组和高、中、低剂量复肝肽 CCl4组(复肝肽的剂量分别为2.5、5.0、10.0 ml/kg),每组10只.采用CCl4致小鼠化学性肝损伤模型,观察各组小鼠肝损伤情况.结果 与CCl4模型对照组比较,中剂量复肝肽 CCl4组小鼠血清丙氨酸氨基转移酶(ALT)活力明显降低,差异有统计学意义(P＜0.01);肝脏组织细胞变性、坏死程度明显减轻,差异有统计学意义(P＜0.05).与CCl4模型对照组比较,高剂量复肝肽 CCl4组小鼠肝脏组织细胞变性程度减轻,差异有统计学意义(P＜0.05).结论 复肝肽对四氯化碳急性染毒致小鼠肝损伤的愈复有促进作用.     

复肝肽对动物实验性肝损伤的保护作用

ｓｃ复肝肽（ＦＧＰ）对四氯化碳和硫代乙酰胺引起的小鼠急性肝损伤具有明显的保护作用，ＦＧＰ可抑制上述肝脏毒物引起的动物血清中谷丙转氨酶活性的升高，降低脂质过氧化产物──丙二醛含量并增加肝糖原含量，对乙硫氨酸引起的小鼠脂肪肝中三酸甘油脂含量也具有明显的降低作用，ＦＧＰ还能明显促进部分切除肝脏小鼠肝组织中ＤＮＡ、ＲＮＡ和蛋白质的合成。此外，还发现ＦＧＰ对四氯化碳引起的大鼠慢性肝损伤亦具有明显的抑制作用。以上结果提示，ＦＧＰ对动物急、慢性肝病的愈复具有明显的促进作用。