The Age-Sensitive Efficacy of Calorie Restriction on Mitochondrial Biogenesis and mtDNA Damage in Rat Liver

Calorie restriction (CR) is the most efficacious treatment to delay the onset of age-related changes such as mitochondrial dysfunction. However, the sensitivity of mitochondrial markers to CR and the age-related boundaries of CR efficacy are not fully elucidated. We used liver samples from ad libitum-fed (AL) rats divided in: 18-month-old (AL-18), 28-month-old (AL-28), and 32-month-old (AL-32) groups, and from CR-treated (CR) 28-month-old (CR-28) and 32-month-old (CR-32) counterparts to assay the effect of CR on several mitochondrial markers. The age-related decreases in citrate synthase activity, in TFAM, MFN2, and DRP1 protein amounts and in the mtDNA content in the AL-28 group were prevented in CR-28 counterparts. Accordingly, CR reduced oxidative mtDNA damage assessed through the incidence of oxidized purines at specific mtDNA regions in CR-28 animals. These findings support the anti-aging effect of CR up to 28 months. Conversely, the protein amounts of LonP1, Cyt c, OGG1, and APE1 and the 4.8 Kb mtDNA deletion content were not affected in CR-28 rats. The absence of significant differences between the AL-32 values and the CR-32 counterparts suggests an age-related boundary of CR efficacy at this age. However, this only partially curtails the CR benefits in counteracting the generalized aging decline and the related mitochondrial involvement.     

数字化射线检测技术在船舶领域的应用

随着数字射线检测技术的不断发展,CR与DR数字射线检测技术以其检测灵敏度高、检测速度快及底片数据电子化存储等优势越来越广泛地应用于各行业中。针对船舶行业射线检测的主要检测对象(钢板对接焊缝、管路对接焊缝),开展了CR数字射线检测技术等价性评价、典型裂纹试验,以及基于不同种类射线装置的DR数字射线检测工艺试验,验证了数字化射线检测技术在船舶领域应用的适用性。     

Role of Polyinosinic:Polycytidylic Acid-Induced Maternal Immune Activation and Subsequent Immune Challenge in the Behaviour and Microglial Cell Trajectory in Adult Offspring: A Study of the Neurodevelopmental Model of Schizophrenia

Multiple lines of evidence support the pathogenic role of maternal immune activation (MIA) in the occurrence of the schizophrenia-like disturbances in offspring. While in the brain the homeostatic role of neuron-microglia protein systems is well documented, the participation of the CX3CL1-CX3CR1 and CD200-CD200R dyads in the adverse impact of MIA often goes under-recognized. Therefore, in the present study, we examined the effect of MIA induced by polyinosinic:polycytidylic acid (Poly I:C) on the CX3CL1-CX3CR1 and CD200-CD200R axes, microglial trajectory (MhcII, Cd40, iNos, Il-1β, Tnf-α, Il-6, Arg1, Igf-1, Tgf-β and Il-4), and schizophrenia-like behaviour in adult male offspring of Sprague-Dawley rats. Additionally, according to the “two-hit” hypothesis of schizophrenia, we evaluated the influence of acute challenge with Poly I:C in adult prenatally MIA-exposed animals on the above parameters. In the present study, MIA evoked by Poly I:C injection in the late period of gestation led to the appearance of schizophrenia-like disturbances in adult offspring. Our results revealed the deficits manifested as a diminished number of aggressive interactions, presence of depressive-like episodes, and increase of exploratory activity, as well as a dichotomy in the sensorimotor gating in the prepulse inhibition (PPI) test expressed as two behavioural phenotypes (MIA_PPI-low and MIA_PPI-high). Furthermore, in the offspring rats subjected to a prenatal challenge (i.e., MIA) we noticed the lack of modulation of behavioural changes after the additional acute immune stimulus (Poly I:C) in adulthood. The important finding reported in this article is that MIA affects the expression and levels of the neuron-microglia proteins in the frontal cortex and hippocampus of adult offspring. We found that the changes in the CX3CL1-CX3CR1 axis could affect microglial trajectory, including decreased hippocampal mRNA level of MhcII and elevated cortical expression of Igf-1 in the MIA_PPI-high animals and/or could cause the up-regulation of an inflammatory response (Il-6, Tnf-α, iNos) after the “second hit” in both examined brain regions and, at least in part, might differentiate behavioural disturbances in adult offspring. Consequently, the future effort to identify the biological background of these interactions in the Poly I:C-induced MIA model in Sprague-Dawley rats is desirable to unequivocally clarify this issue.     

丁腈橡胶/聚氯乙烯共混胶在钢丝编织液压胶管中的应用研究

研究了丁腈橡胶/聚氯乙烯共混胶(NV5075)替代丁腈橡胶和氯丁橡胶,用作钢丝编织液压胶管的胶料。试验表明,该共混物作为胶管内胶、中胶和外胶有许多优点,诸如耐臭氧老化优良、耐油性能提高、抗撕裂性能改善、门尼焦烧时间长(加工安全)、挤出性能好、表面光滑、不赶胶、挤出的内外管坯挺性好、挤出膨胀率低、尺寸稳定性好等。通过合理的配方设计,胶管成品的全部检验项目均符合国家标准GB/T 3683—2011的要求。     

Modeling and analysis of customer premise equipments registration process in IEEE 802.22 WRAN cell

The development of the IEEE 802.22 standard is aimed at providing broadband access in rural areas by effectively utilizing the unused TV band, provided no harmful interference is caused to the incumbent operation. The motivation behind TV band selection is of having lower frequencies compared to other licensed bands, which, therefore, results in lower propagation path loss. Due to this quality, the spectral power density of the radio signal reduces slowly, which results in a high coverage area. Further, it has been observed that many TV channels largely remain unoccupied, as most households and businesses rely on cable and satellite TV services. This is the first international standard for a wireless regional area network (WRAN) based on cognitive radio technologies. This standard provides both PHY and MAC layer functionalities in an infrastructure based network for communication between customer premise equipments (CPEs) through a base station (BS). The Spectrum Manager is the central part of the BS, which plays a significant role in maintaining spectrum availability information, channel selection, channel management, scheduling quiet periods for spectrum sensing, accessing to the database and implementing IEEE 802.22 policies. A WRAN can particularly accommodate up to 512 CPEs in a cell. Contention may occur during initial ranging, periodic ranging, bandwidth request and urgent coexistence situation notification. The medium access control (MAC) incorporates several schemes to control contention between CPEs within a cell and overlapping cells sharing the same channel. A CPE has to make decision to resolve collisions in the upstream direction. In the case of initial ranging and periodic ranging, code division multiple access (CDMA) is employed to resolve collisions. For bandwidth and UCS notification, either a CDMA or exponential time backoff approach can be applied for collision resolution. This paper presents the analytical framework to evaluate the number of active CPEs in a cognitive radio network. It is important to note that when the arrival rate becomes equal to the service rate, the active CPEs curve attains a constant value. Further, the active CPEs length is highly dependent on service rate. The different special cases have been addressed and the effectiveness of the proposed framework has been validated through various evaluation results.     

Microstructure, mechanical properties and electrical conductivity of industrial Cu-0.5%Cr alloy processed by severe plastic deformation

Microstructure, mechanical properties and electrical conductivity of industrial Cu-0.5% alloy subjected to equal channel angular pressing (ECAP) by route A and cold rolling with and without aging treatment were investigated. The lamellar grains in thickness of 100 nm were obtained after eight ECAP passes. They were not further pancake shaped, but fragmentary and obtained less sharp boundaries with more dislocations in addition to cold rolling. After aging at 450 °C for 1 h, high density of dislocations and some coarse grains were observable after ECAP and the additional cold rolling, respectively. The tensile tests show that tensile strength arrived at 460 MPa and 484 MPa after four and eight passes of ECAP, respectively, the corresponding tensile strength increased to 570 MPa and 579 MPa after the additional cold rolling. However, the electrical conductivity was not more than 35% IACS. It was proved that four passes of ECAP followed by 90% cold rolling and aging at 450 °C for 1 h offered a short process for Cu-0.5%Cr alloy to balance the paradox of high strength and electrical conductivity, under which the tensile strength 554 MPa, elongation to failure 22% and electrical conductivity 84% of IACS could be obtained. The high strength was explained by precipitation strengthening and fine grain strengthening.     

表面处理对第二代单晶高温合金胞状再结晶的影响

对第二代镍基单晶高温合金进行表面处理并在1000～1200℃保温,研究表面加工工艺和热处理条件对胞状再结晶行为的影响.结果表明:磨削、吹砂、喷丸试样热处理后表面均发生了胞状再结晶,其生成厚度依次增加.喷丸试样经1200℃/50h后胞状再结晶区厚度可达0.1mm,晶团之间及与基体之间存在取向差小于5°的小角晶界和35～4...     

Enhancing TRU burning and Am transmutation in Advanced Recycling Reactor

This paper presents about conceptual designs of Advanced Recycling Reactor (ARR) focusing on enhancement in transuranics (TRU) burning and americium (Am) transmutation. The design has been conducted in the context of the Global Nuclear Energy Partnership (GNEP) seeking to close nuclear fuel cycle in ways that reduce proliferation risks, reduce the nuclear waste in the US and further improve global energy security. This study strives to enhance the TRU burning and the Am transmutation, assuming the development of related technologies in this study, while the ARR based on mature technologies was designed in the previous study. It has followed that the provided TRU burning core is designed to burn TRU at 28 kg/TW_thh, by adding moderator pins of B₄C (Enriched B-11) and the Am transmutation core will be able to transmute Am at 34 kg/TW_thh, by locating Am blanket of AmN around the TRU burning core. It indicates that these concepts improve TRU burning by 40-50% than the previous core and can transmute Am effectively, keeping the void reactivity acceptable.     

基于分形盒维数的双门限合作频谱感知方法

在信号分形盒维数特征的基础上,提出利用噪声与授权信号分形盒维数的差异对授权用户是否存在进行检测.为了使合作感知性能趋于更优,多用户采用双门限策略进行分步合作.该方法运算复杂度低,对噪声不敏感.仿真结果表明,双门限合作相比单门限分形盒维数检测和能量检测,系统检测率更高,所需频谱感知时长较短,同时减轻了融合控制中心以及传输...     

基于压缩感知的分步合作频谱感知方法

在研究自相关矩阵检测理论的基础上,提出一种采用压缩感知的分步合作频谱感知方法.通过压缩感知将海量采样数据量减小,提取能够有效代表原信号的采样点;通过随机选择参与运算的认知用户及其数量进行合作检测,并反馈有益信息,减少了传统合作检测所有认知用户参与检测带来的运算复杂度.仿真表明该方法提高了频谱检测率,缩短了频谱检测时长,...