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排序方式: 共有480条查询结果,搜索用时 218 毫秒
1.
Sijie Wang Dr. Aktan Alpsoy Surbhi Sood Sandra Carolina Ordonez-Rubiano Dr. Alisha Dhiman Yixing Sun Guanming Jiao Dr. Casey J. Krusemark Dr. Emily C. Dykhuizen 《Chembiochem : a European journal of chemical biology》2021,22(13):2335-2344
Polycomb group (PcG) proteins are epigenetic regulators that facilitate both embryonic development and cancer progression. PcG proteins form Polycomb repressive complexes 1 and 2 (PRC1 and PRC2). PRC2 trimethylates histone H3 lysine 27 (H3K27me3), a histone mark recognized by the N-terminal chromodomain (ChD) of the CBX subunit of canonical PRC1. There are five PcG CBX paralogs in humans. CBX2 in particular is upregulated in a variety of cancers, particularly in advanced prostate cancers. Using CBX2 inhibitors to understand and target CBX2 in prostate cancer is highly desirable; however, high structural similarity among the CBX ChDs has been challenging for developing selective CBX ChD inhibitors. Here, we utilize selections of focused DNA encoded libraries (DELs) for the discovery of a selective CBX2 chromodomain probe, SW2_152F. SW2_152F binds to CBX2 ChD with a Kd of 80 nM and displays 24-1000-fold selectivity for CBX2 ChD over other CBX paralogs in vitro. SW2_152F is cell permeable, selectively inhibits CBX2 chromatin binding in cells, and blocks neuroendocrine differentiation of prostate cancer cell lines in response to androgen deprivation. 相似文献
2.
P. Matzke J. Strassmann G. Andersohn M. Oechsner 《Materialwissenschaft und Werkstofftechnik》2019,50(12):1598-1606
A sophisticated thermal management is one of the main subsystems that enables combustion engines with high power density. In this context the demands on coolants are also increasing. There has to be a certain level of corrosion protection to ensure the functionality of the cooling system. Hereafter the result of an electrochemical sensor development is presented. With the knowledge of analytical and electrochemical results a quick test for characterizing coolants corrosion protection has been developed and validated. 相似文献
3.
Corrosion inhibition by red pepper seed oil (capsicol) on 304 stainless steel (SS) was studied in 1 M HCl solutions. The oil was extracted from the seed of the red pepper (Capsicum annuum L.), which was cultivated in East Java, Indonesia. Electrochemical and optical microscopy techniques were used to observe the performance of the corrosion-inhibition process. The inhibition efficiency reached 92.32% for an immersion time in capsicol of 30 min at room temperature and decreased with temperature. This inhibition behavior by capsicol was also justified by comparing the pictures of the samples with and without the inhibitor after corroding for one week. 相似文献
4.
《Ceramics International》2022,48(20):30151-30163
The effect of polymeric nanocapsule capping in benzotriazole encapsulated into halloysite nanoclay (HNTs) dispersed into hybrid silica coatings was investigated for corrosion protection of mild steel. Optimization of the amount of inhibitor-loaded halloysite nanotubes with and without capping in the coating sol was carried out. The prepared formulations were dip-coated on mild steel substrates using dip-coater and then cured at 130 °C for 1 h. Surface morphology and elemental analysis of the nanoclay were studied using scanning electron microscopy and energy dispersive X-ray spectroscopy. X-ray diffraction and Fourier Transform Infrared spectroscopy analyses were carried out to confirm the encapsulation and capping of the halloysite nanoclay. The anti-corrosion and autonomic-healing properties of bare and coated substrates in 3.5 wt% NaCl solution were studied using electrochemical impedance spectroscopy, potentiodynamic polarization measurements and scanning vibrating electrode technique for varying exposure times. The coatings generated from the capped inhibitor-loaded HNTs dispersed sol-gel matrix was seen to provide higher corrosion resistance when compared to uncapped HNT based silica coatings. Electrochemical studies carried out for capped inhibitor-loaded HNT based coatings have shown an increase in charge transfer resistance to 108 Ω cm2 from 106 Ω cm2 of uncapped inhibitor-loaded HNT based coatings. 相似文献
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6.
France Millet Rémi Auvergne Sylvain Caillol Ghislain David Abdelatif Manseri Nadine Pébère 《Progress in Organic Coatings》2014
Six formulations containing diacrylate monomers (from 89 to 92.5% (w/w)) as well as a phosphonated methacrylate monomer (from 1 to 10% (w/w)) were prepared. All formulations were UV-cured and the corrosion performance of the resulting coatings applied onto a steel substrate was assessed by electrochemical impedance spectroscopy (EIS). It was first shown that the coatings containing phosphonic acid methacrylate (MAPC1(OH)2) instead of methacrylate phosphonic dimethyl ester (MAPC1) presented higher corrosion protection related to the strong adhesive properties of phosphonic acid on the metal substrate. A minimum MAPC1(OH)2 content of 2.5% was determined to provide the highest impedance values (best efficiency). Then, a new bio-based compound, i.e. phosphonic acid-bearing oleic acid (phosphonated fatty acid), was synthesized and added as an inhibitor to the formulations. In the presence of this compound, the corrosion protection was notably improved. The beneficial effect of phosphonated fatty acid was explained by its inhibitive action at the steel/coating interface and by the improvement of the barrier properties. 相似文献
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8.
Yeo-Myeong Yun Si-Kyung Cho Kyung-Won Jung Mi-Sun Kim Hang-Sik Shin Dong-Hoon Kim 《International Journal of Hydrogen Energy》2014
To improve the sustainability of microalgae as a bioenergy feedstock, lipid-extracted microalgae (LEM) are often further treated by anaerobic digestion (AD). However, the residual chloroform used for extracting lipids as a solvent could inhibit this process, an aspect that has not been studied to date. In this study, the inhibitory effect of chloroform on H2 and CH4 production was investigated by performing batch tests. To prepare the feedstock, Chlorella vulgaris was ultrasonicated and the supernatant was discarded after centrifugation. In case of H2 production, it was found that the H2 yield fell to almost half that of the control (15.6 mL H2/g CODadded) at 100 mg CHCl3/L. The reason for the decrease of the H2 yield with the increase of chloroform level was due to the change of metabolites from acetate and butyrate to lactate via a non-hydrogenic reaction. In comparison with H2 production, a much more severe inhibitory effect of chloroform on CH4 production was observed. The inhibitor concentration (IC30, 60, and 90) on H2 production was 138, 319, and 622 mg CHCl3/L, respectively, while concentrations of 15, 37, and 86 mg CHCl3/L were obtained on CH4 production. When the chloroform concentration was ≥25 mg/L on CH4 production, more than 2 g COD/L of organic acids remained, resulting in a decrease of CH4 yield. These findings indicate that the residual chloroform in LEM should be seriously considered to prevent possible microbial inhibition when designing a process for additional energy recovery from microalgae via AD. 相似文献
9.
10.
The inhibiting effect of two Schiff bases on the corrosion of the mild steel (MS) in 1 M HCl has been studied by electrochemical impedance spectroscopy (EIS) and Tafel polarisation measurements. The Schiff bases, 4,4′-bis(3-carboxaldehyde thiophene) diphenyl diimino ether (L1) and 4,4′-bis(3-carboxaldehyde thiophene) diphenyl diimino ethane (L2), were synthesized using 3-carboxaldehydethiophene and its corresponding amine. Polarisation curves reveal that both compounds are mixed type (cathodic/anodic) inhibitors and inhibition efficiency (% IE) increases with increasing concentration of compounds. It is suggested that their effects depend on their concentrations and the molecular structures. Adsorption of compounds on mild steel surface is spontaneous and obeys Langmuir’s isotherm. 相似文献