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1.
陈振华 《中国卫生标准管理》2020,(8):76-79
目的探讨儿童流感应用帕拉米韦注射液治疗的临床疗效以及用药安全性。方法随机选定在2016年1月-2019年1月期间佛山市高明区人民医院儿科住院治疗并确诊流感A或B型患儿200例,通过随机数字法将其分为治疗组和对照组。治疗组100例用帕拉米韦注射液治疗,对照组100例用国产磷酸奥司他韦颗粒治疗,评价两组患儿治疗前后症状评分、治疗效果、治疗指标以及不良反应发生情况。结果两组患儿治疗前流感样症状评分无统计学意义(P>0.05),两组患儿治疗后较治疗前流感样症状评分均下降,差异有统计学意义(P<0.05);治疗组治疗后流感样症状评分略小于对照组,但是无统计学意义(P>0.05);治疗组治疗总有效率高于对照组,治疗组患儿发热症状缓解、全部症状缓解以及住院时间均小于对照组,存在统计学意义(P<0.05)。治疗组与对照组不良反应发生率较低,且无统计学意义(P>0.05)。结论帕拉米韦注射液可用于儿童流感治疗,不仅能够保证临床疗效,而且可加快症状缓解,同时存在较高用药安全性。 相似文献
2.
In this study breast tissue that contained ultrastructural dense core granules has been examined from 24 patients. The possible neuroendocrine characteristics of the granules were studied using the uranaffin reaction and an ultrastructural argyrophil stain. The tissue included 15 breast carcinomas and nine benign samples. Two types of breast dense core granules can be distinguished on the basis of intracellular distribution patterns and histochemical reactivity. Type I dense core granules are the most common and they were found subluminally distributed in non-pathological tissues and benign lesions as well as carcinomas. They were uranaffin-negative and are unlikely to be of endocrine nature. Type II dense core granules were found only in four carcinomas, where they occurred abundantly throughout the cytoplasm. These granules were uranaffin-positive and argyrophilic and thus exhibited characteristics consistent with neuroendocrine structure. 相似文献
3.
Abstract: Ultrafiltration of water from blood to dialysate decreases the rate of back–diffusion of solutes from dialysate to blood. Therefore, back–clearance ( bK ) of hemodialyzers may be expressed as bK = bK o – bTrQ u , where bK o is the diffusive back–clearance, bTr is the "back–"transmittance coefficient, and Qu is the net ultrafiltration rate. A formula for bK was derived from the one–dimensional theory of hemodialyzer, and bTr was described as a function of bK o and the Staverman reflection coefficient. The transport parameters, bK o and bTr , for creatinine and vitamin B12 were measured in two types of hemodialyzers with negligible back–filtration, using water solutions, and compared with the transport parameters, K o and Tr , for the case of both diffusion and ultrafiltration from blood to dialysate. bK o was in general equal to Ko . bTr was not different from Tr for creatinine whereas bTr was lower than Tr for vitamin B12 . Experimental values of bTr for vitamin B12 were in general agreement with theoretical predictions. However, experimental values of bTr for creatinine were lower than predicted values. We conclude that the impact of ultrafiltration on back–clearance for slowly diffusing solutes is weaker than on their clearance. 相似文献
4.
Actinomycetous infections typically involve either the head and neck or the extremities following a traumatic implantation.
Classic clinical associations are draining sinus tracts. This case report describes the pathologic and MR findings of a relatively
acute mycetomatous process involving the soft tissues. Pathologic findings in this case included an occasional granule composed
of gram positive, thin branching elements. These and other findings were consistent with actinomycetes bacterium infection.
The discussion centers around the use of MR, both with and without gadolinium, in evaluating this type of granulomatous infection.
Infiltration of the adjacent subcutaneous tissues was easier to appreciate on both the T1-weighted images without gadolinium
and the T1-weighted images with gadolinium when compared to the T2-weighted images. Signal characteristics as described in
this case report may suggest a granulomatous process. 相似文献
5.
6.
R. Magdeburg R. Grobholz G. Dornschneider S. Post D. Bussen 《Techniques in coloproctology》2007,11(4):372-374
Most cases of anal abscess are caused by anal fistula and invasion of the surrounding tissues by a mixed colonic flora. Treatment
consists of excision of the abscess and, in case of fistula, fistulectomy. Primary anorectal and perianal forms of actinomycosis
are very rare and caused by actinomyces, as ubiquitous anaerobics bacterium. We report a case of perianal actinomycosis. The
patient had a short history of painless perineal induration without fever and leukocytosis with normal results at routine
blood examination. After excision, sulfur granules drained from the cavity and pathological investigations indicated perianal
actinomycosis. Appropriate surgery and antibiotic treatment healed the perianal infection. After exclusion of possible diagnoses
such as Crohn’s disease, tuberculosis and malignant growths, the rare case of perianal actinomycosis should be considered
in the differential diagnosis of painless perianal masses. 相似文献
7.
不同置换液量血液透析滤过治疗尿毒症皮肤瘙痒疗效观察 总被引:5,自引:0,他引:5
目的:观察不同置换液量血液透析滤过(HDF)对尿毒症皮肤瘙痒的治疗作用。方法:将30例并发皮肤瘙痒的维持性血液透析尿毒症患随机分为三个组,分别接受高置换液量后稀释HDF(置换液20L)、低置换液量后稀释HDF(置换液10L)和高通量血液透析治疗。均使用F60透析器,隔日1次,连续3次,其余治疗条件相同。对皮肤瘙痒症状定量计分,比较三组病人治疗前后皮肤瘙痒症状积分的改变以及血磷和甲状旁腺激素(PTH)的变化。结果:高置换液量HDF组治疗后皮肤瘙痒积分明显下降,有统计学意义。其余两组无差异。以皮肤瘙痒积分下降50%为有效计算,高置换液量HDF组7例有效,有效率70%;低置换液量HDF组3例有效。有效率30%;透析组1例有效,有效率10%。三组间比较有统计学差异。三组透析后血磷均明显下降,有统计学意义;PTH亦有下降,HDF组有统计学差异,HD组无统计学差异。结论:增加置换液量可以提高HDF治疗尿毒症皮肤瘙痒的疗效;HDF治疗尿毒症皮肤瘙痒疗效优于高通量血液透析;HDF清除PTH的效果高于HD。 相似文献
8.
宣肺清热颗粒剂稳定性研究 总被引:1,自引:0,他引:1
目的:研究宣肺清热颗粒剂中橙皮甙热稳定性变化,为该颗粒剂有效期的确定、制剂生产、贮存条什提供实验参考依据。方法:采用加速实验法对橙皮甙热稳定性进行研究,用甲醇超声提取样品,HPLC进行含量测定。根据Arrhenius公式处理数据。结果:Arrhenius公式得室温下的速度常数K298=3.38×10-5/h,得出常温下该颗粒剂以橙皮甙为指标的有效期为3.6年。结论:宣肺清热颗粒剂稳定性好,初步符合中药稳定性要求。 相似文献
9.
W. J. Hofmann Herwart F. Otto W. Wöckel O. Thetter 《Virchows Archiv : an international journal of pathology》1995,425(6):641-646
A melanotic paraganglioma occurred in a 57-year-old woman, located in the left paravertebral space of the upper mediastinum. It was totally resected. During a 5 year follow up period neither tumour reccurrence nor metastasis were observed. Histological examination of the tumour revealed a paraganglioma with monomorphous chief cell like elements which were arranged in a zellballen pattern. Immunohistochemical results also were in accordance with the diagnosis since neuron-specific enolase, chromogranin and synaptophysin were found in tumour cells whereas keratin was not. Additionally, neurosecretory granules were found in tumour cells during electron microscopy. A peculiar feature of the tumour was its strong pigmentation due to melanin located within the tumour cells and tumour associated melanophages. The simultaneous expression of functional properties of two different neural crest derived cells in one tumour stresses the close relationship between all neural crest elements and is in accordance with the observation of other melanotic, non-melanomatous tumours.Dedicated to Prof. Dr. Dr. mult. h.c. W. Doerr on the occasion of his 80th birthday 相似文献
10.
Eberhard Ritz Burkhard Krempien Gabriele Klefisch Theresia Ritter Eva Krause 《Virchows Archiv : an international journal of pathology》1977,376(2):145-157
Summary Uremic women on hemodialysis with metabolic bone disease (hyperparathyroidism, osteomalacia resulting from defective vitamin D metabolism) and anemia (erythropoietin deficiency) are known to give birth to infants without bone disease or anemia. Therefore, skeletal development (enchondral and desmal bone formation) and hepatic erythropoiesis were evaluated in fetuses of uremic rats. These fetuses failed to show defective mineralisation or evidence of bone disease. Bolus injection of high doses of exogenous PTH into the maternal or fetal organism did not affect fetal bone histology. In addition, no apparent defect of bone mineralisation or bone formation was found in fetuses of ricketic rats. Normal mineralisation in the offspring of uremic rats may be explained by fetal hyperphosphatemia and/or insensitivity of fetal (woven) bone mineralisation to vitamin D.Absence of fetal anemia (normal hematocrits, normal density of hematopoietic cells in the liver) in the presence of maternal anemia is presumably due to the insensitivity of fetal erythropoiesis to erythropoietin.With the support of Deutsche Forschungsgemeinschaft 相似文献