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排序方式: 共有1045条查询结果,搜索用时 188 毫秒
1.
甘草黄酮的提取分离和含量测定 总被引:21,自引:0,他引:21
封士兰 《兰州大学学报(医学版)》1998,(4)
目的:充分利用甘草资源。方法:从提取过甘草酸的废渣中提取甘草黄酮并进行含量测定。结果:用碱酸处理和用大孔树脂处理黄酮含量高,收率也高。结论:从甘草废渣中提取甘草黄酮具有较好的社会效益和经济效益 相似文献
2.
目的:对天峨野生大果山楂(Malus doumeri)酒中氨基酸(游离氨基酸,水解氨基酸),总黄酮进行含量测量。方法:利用高速氨基酸分析仪和分光光度计分别测定该酒中游离氨基酸,水解氨基酸和总黄酮类的含量。结果:该酒含17种游离氨基酸,含量为30.89%,16种水解氨基酸,含量为99.25%;总黄酮含量为15.43%(单位mg/ml)。结论:该酒富含氨基酸和总黄酮化合物,具有较强的生物活性。 相似文献
3.
目的:观察高良姜、大高良姜、红豆蔻黄酮类成分对胃溃疡寒证大鼠环核苷酸水平及交感神经-肾上腺轴的影响,探讨3味山姜属中药温热药性的物质基础。方法:采用灌服冰知母水煎液与15%冰乙酸制备大鼠胃溃疡寒证模型,以干姜姜辣素为阳性对照,采用酶联免疫吸附试验(ELISA)法测定腺苷酸环化酶(AC)、磷酸二酯酶2(PDE2)、环磷酸腺苷(cAMP)、环磷酸鸟苷(cGMP)、促肾上腺皮质激素(ACTH)、多巴胺β羟化酶(D-β-H)含量。结果:与空白组比较,胃溃疡寒证模型组大鼠胃组织AC、cAMP含量及cAMP/cGMP比值显著降低,PDE2含量显著升高(P<0.01)。与模型组比较,高良姜、大高良姜、红豆蔻高低剂量组大鼠胃组织AC含量升高;高良姜、大高良姜、红豆蔻高低剂量组大鼠胃组织PDE2含量显著降低,cAMP含量、cAMP/cGMP比值显著升高(P<0.01或P<0.05)。结论:3味山姜属中药黄酮类成分通过调节胃溃疡寒证大鼠环核苷酸水平从而促进交感神经-肾上腺轴功能活动的作用,也体现出黄酮类成分药性温热。 相似文献
4.
加杨雄花序的化学成分研究 总被引:8,自引:0,他引:8
首次对加杨雄花序了条统从其撮物的石油醚(60~90℃)部分,乙酸乙酯部分分离并鉴定了15个化合物,本语文报道8个黄酮类成分,乔松酮(pinostrobin,1),高良姜素-3-甲氧基(ga/langin 3 methoxy,2),乔松索(pinocermbin,2),白杨素(chrysin,4)槲皮素-3,7-二甲氧基(quercetin0-3,7-dimethoxy,5),鼠李素(rhammet 相似文献
5.
Summary
Background & Aims: Epidemiological studies suggest that antioxidant polyphenols in the human diet may protect against diseases such as cancer.
In this study we investigated the cytoprotective potential of the flavonoids, quercetin, myricetin, kaempferol and rutin against
oxidative DNA damage in human colonocytes in vitro.
Methods: Caco-2 cells, which display specialised enterocyte/colonocyte cell functions, were used as an in vitro model for human colonocytes. Hydrogen peroxide was employed as the oxidant. DNA damage (strand breakage, oxidised purines
and oxidised pyrimidines) was determined using the alkaline single cell gel electrophoresis or comet assay. Cell growth and
viability were measured.
Results: Hydrogen peroxide caused a dose-dependent increase in DNA strand breakage in human colonocytes, presumably via oxygen free
radical generation. Quercetin and myricetin protected Caco-2 cells against oxidative attack. In addition, quercetin decreased
hydrogen peroxide-mediated inhibition of growth. Neither rutin nor kaempferol was effective. However, quercetin, while inhibiting
DNA strand breakage, did not alter the levels of oxidised bases following peroxide treatment. The antifungal agent ketoconazole,
prevented quercetin cytoprotection in Caco-2 cells, indicating that P450-mediated metabolism may alter the efficacy of the
flavonoids against oxidative DNA damage.
Conclusion: Flavonoids, particularly quercetin, the most abundant flavonoid in the human diet, are likely to be important in defending
human colonocytes from oxidative attack.
Received: 7 October 1998, Accepted: 5 November 1998 相似文献
6.
H. Glossmann P. Presek E. Eigenbrodt 《Naunyn-Schmiedeberg's archives of pharmacology》1981,317(1):100-102
Summary The bioflavonoid quercetin is a potent inhibitor of a cyclic nucleotide-independent, tumor virus-coded protein kinase which phosphorylates tyrosine residues and acts as a cellular transforming protein. Half-maximal inhibition of the protein kinase occurred at 3–4 M quercetin whereas rutin was much less effective. The finding, that quercetin inhibits a cyclic nucleotide-independent protein kinase activity, may provide clues to the diverse pharmacological effects of the bioflavonoids. 相似文献
7.
J. W. L. Robinson M. L'Herminier H. G. A. Claudet 《Naunyn-Schmiedeberg's archives of pharmacology》1979,307(1):79-89
Summary Naringenin (4,5,7-trihydroxy-flavanone) inhibits the accumulation of glycine, -methyl-glucoside, p-amino-hippurate and N1-methyl-nicotinamide in dog renal cortex slices. It also inhibits oxygen consumption by this tissue. Since the sensitivity of amino-acid uptake to the drug is less than the sensitivity of oxygen consumption, the inhibition of this transport might be secondary to an effect on intermediary metabolism. The inhibition of PAH uptake occurs at a lower concentration of the drug, and so naringenin may affect this process at the membrane level.Naringenin inhibits the transport of sugars and amino-acids by dog, guinea-pig and rat small intestine. Both steady-state accumulation and initial rates of entry are affected. Amino-acid uptake is depressed both in the presence or absence of sodium ions. The inhibition is reversible provided short contact times are employed. According to kinetic analysis, naringenin appeared to be a fully non-competitive inhibitor of phenylalanine influx. Examination of the unidirectional transmural fluxes of phenylalanine across guinea-pig intestine revealed that only the mucosal-serosal flux was affected, and then only if the flavanone was added to the solution bathing the mucosal face of the tissue. Naringenin does not inhibit mucosal Na+-K+-ATPase, but it does alter the intracellular ion concentrations.Although some of the results can be explained in terms of an effect of naringenin on metabolism, others can not. It is argued that naringenin has a direct action on cell membranes.Some of these results have been presented to the Physiological Society and a short report has appeared in their proceedings (Robinson, 1979) 相似文献
8.
目的研究银叶树Heritieralittoralis D.的化学成分.方法利用硅胶柱层析进行分离和纯化,并通过波谱分析鉴定结构.结果从银叶树的叶子中分离鉴定了8个黄酮类化合物,分别为栎皮苷(quercitrin 1),槲皮素(quercetin 2),山柰酚-3-O-(6"-0-E-p-香豆酰基)-β-D-吡喃葡萄糖(kaempferol-3-O-(6"-O-E-p-coumroyl)-β-D-gluco-pyranoside 3),山柰酚(kaempferol 4),山柰苷(kaempferitrin5),杨梅黄酮(myricetin 6),圣草酚(eriodictyol 7)和儿茶素(catechin 8).结论化合物2-8首次从该植物中分离得到. 相似文献
9.
10.
球花石斛的化学成分研究(Ⅰ) 总被引:10,自引:4,他引:10
目的:研究兰科植物球花石斛的化学成分,以探明其有效成分并为制定中药石斛质量标准提供科学依据。方法:采用硅胶、Sephadex LH-20及RP-C18等色谱技术分离纯化化合物,根据理化性质、光谱数据鉴定结构。结果:从球花石斛乙醇提取物的乙酸乙酯部位分离得到芴酮类、联苄类、菲类及黄酮类13个化合物,分别鉴定为4,7-二羟基-5-甲氧基芴酮(Ⅰ)、1,4,7-三羟基-5-甲氧基芴酮(Ⅱ)、2,4,7-三羟基-4-甲氧基芴酮(Ⅲ)、2,5,9-三羟基-4-甲氧基芴(Ⅳ)、4,4‘-二羟基-3,3‘,5,-三甲氧基联苄(V)、5,4‘-二羟基-3,3‘-二甲氧基联苄(Ⅵ)、3,5,4‘-三羟基-3‘-甲氧基联苄(Ⅶ)、2,5-二羟基-4-甲氧基菲(Ⅷ)、2,5-二羟基-4-甲氧基-9,10-二氢菲(Ⅸ)、二氢麦黄酮(X)、柯伊利素(Ⅺ)、高北美圣草素(Ⅻ)、柚皮素(XⅢ)。结论:化合物Ⅸ,X,Ⅺ为首次从石斛属中分离得到,其它化合物均为首次从该种植物中分离得到. 相似文献