优化温针灸流程对不良事件发生及患者舒适度的影响

目的:观察优化温针灸流程对患者温针灸过程中不良事件发生及舒适度的影响。方法:选取行温针灸治疗的140例患者为研究对象,按随机数字表法分为观察组和对照组各70例。对照组采用传统纸片承接散灰,观察组使用锡纸圆杯代替传统纸片。结果:观察组无不良事件发生。对照组出现不良事件频率较高,其中灰烬跌落床单和灰烬跌落皮肤发生率与观察组比较,差异均有统计学意义(P<0.05)。观察组舒适度优于对照组,差异有统计学意义(P<0.05)。结论:优化温针灸流程在温针灸过程中能减少不良事件发生,提高患者的舒适度。     

Robust rigid registration of retinal angiograms through optimization

Retinal fundus photographs are employed as standard diagnostic tools in ophthalmology. Serial photographs of the flow of fluorescein and indocyanine green (ICG) dye are used to determine the areas of the retinal lesions. For objective measurements of features, the registration of the images is a necessity. In this paper, we employ optimization techniques for registration with the help of 2-parameter translational motion model of retinal angiograms, based on non-linear pre-processing (Wiener filtering and morphological gradient) and computation of the similarity criteria for the alignment of the two gradient images for any given rigid transformation. The optimization methods are effectively employed to minimize the similarity criterion.

The presence of noise, the variations in the background and the temporal variation of the fluorescence level pose serious problems in obtaining a robust registration of the retinal images. Moreover, local search strategies are not robust in the case of ICG angiograms, even if one uses a multiresolution approach.

The present work makes a systematic comparison of different optimization techniques, namely the minimization method derived from the optical flow formulation, the Nelder-Mead local search and the HCIAC ant colony metaheuristic, each optimizing a similarity criterion for the gradient images. The impact of the resolution and median filtering of gradient image is studied and the robustness of the approaches is tested through experimental studies, performed on macular fluorescein and ICG angiographies.

Our proposed optimization techniques have shown interesting results especially for high resolution difficult registration problems. Moreover, this approach seems promising for affine (6-parameter motion model) or elastical registrations.     

散结消肿贴中大黄重楼提取工艺优选研究

目的：优选散结消肿贴中大黄、重楼的渗漉提取工艺。方法：以总固体物得率和总蒽醌得率为指标，用正交实验优选。结果：工艺中影响最大的因素是乙醇浓度，其次是乙醇用量，浸泡时间影响较小。最佳工艺条件为乙醇浓度65％，乙醇用量8倍量。浸泡时间24h。结论：渗漉法操作简单，成份破坏少，用优选所得条件进行提取，总蒽醌和总固体物得率均较高，优选结果可用于散结消肿贴中大黄、重楼的提取。     

睡眠过渡过程监测的新方法

在系统水平上研究人脑的睡眠过渡过程,以寻求监测睡眠过渡过程的新方法.方法:让15名睡眠良好者进行睡眠中的行为反应实验,获取行为反应量.结果:发现行为反应量与脑电图所反映的脑状态一致,且能反应睡眠过渡过程中脑状态的微小变化.结论:以行为反应量监测睡眠过渡过程,结果可靠,操作简便,对被试者干扰小.     

脑络康缓释胶囊的制备工艺和体外释放度的研究

以羟丙甲基纤维素作为主要的缓释辅料,采用正交设计方法优化处方研制成脑络康缓释胶囊.以人参皂苷的累积释放量作为考察指标,按照<药典>规定的缓释制剂的释放度进行优选.结果:最佳的处方工艺即羟丙甲基纤维素216 mg,乙基纤维素24 mg,混合稀释剂132 mg,释放曲线符合Higuchi动力学模型.     

16例茎突综合征误诊原因分析

目的吸取误诊教训，提高对茎突综合征诊断水平。方法回顾性分析3例茎突综合征误诊的临床资料。结果找出误诊原因，并借助文献进行分析、讨论。结论要熟悉茎突综合征的病因，临床特点和并发症，提高警惕性，发现可茎突综合征病人，及时做医学影像检查和咽部触诊。     

Can the process indicators for emergency obstetric care assess the progress of maternal mortality reduction programs? An examination of UNFPA Projects 2000-2004.

BACKGROUND: In view of the disappointing progress made in the last 20 years in reducing maternal mortality in low-income countries and before going to scale in implementing the new evidence-based strategies, it is crucial to review and assess the progress made in pilot countries where maternal mortality reduction programs focused on emergency obstetric care. OBJECTIVE: To review the process indicators recommended for monitoring emergency obstetric care and their application in field situations, examining the conditions under which they can be used to assess the progress of maternal mortality reduction programs. METHODS: Five of the six UN recommended process indicators were monitored annually for 5 years in selected districts of Morocco, Mozambique, India and Nicaragua. Trends are presented and discussed. RESULTS: With specific variations due to different local situations in the four countries and in spite of variations in quality of data collection, all indicators showed a consistent positive trend, in response to the inputs of the programs. CONCLUSIONS: The UN process indicators for emergency obstetric care should continue to be promoted, but with two important conditions: (1) data collection is carefully checked for quality and coverage; (2) efforts are made to match process and outcome indicators (maternal and perinatal mortality, incidence of complications).     

辣蓼颗粒成型工艺的研究

目的探讨辣蓼颗粒的成型工艺条件。方法考察不同辅料即乳糖、玉米淀粉和糊精对浸膏粉吸湿性的影响；用正交试验法优选制粒工艺条件及评价颗粒的流动性与吸湿性等。结果3种辅料均可明显降低浸膏粉的吸湿性；最佳制粒工艺条件为浸膏粉与玉米淀粉、乳糖按2：2：1的比例混匀，以75％乙醇为润湿剂制软材，湿粒以70％温度干燥，成品颗粒的流动性好；临界相对湿度为75％。结论混合辅料（玉米淀粉和乳糖）可改善浸膏粉的成型性和颗粒剂的抗湿性；辣蓼颗粒制粒工艺条件的优化为产品的工业生产环境控制提供了科学依据。     

Optimization of process parameters for reduction of gossypol levels in cottonseed meal by Candida tropicalis ZD-3 during solid substrate fermentation.

The objective of this work is to optimize the process parameters for detoxification of gossypol in cottonseed meal (CSM) by Candida tropicalis ZD-3 during solid substrate fermentation (SSF). The maximum detoxification efficiency of gossypol was achieved by employing the substrate, which consists of 70% of CSM, 20% of corn flour and 10% of wheat bran. The optimum fermentation conditions for gossypol detoxification are incubation period of 48h, incubation temperature at 30 degrees Celsius, inoculum level 5% v/w, moisture content of solid substrate 50% and pH in nature. Adding minerals solution to CSM substrate benefit fermentation detoxification.