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免疫球蛋白联合鞘内注射激素治疗重症格林-巴利综合征 总被引:2,自引:0,他引:2
目的观察免疫球蛋白联合鞘内注射激素治疗重症格林-巴利综合征的疗效。方法应用Hughes量表评价疗效。结果治疗组起效时间明显短于对照组,治疗组Hughes临床分级评分改善明显优于对照组。结论免疫球蛋白联合鞘内注射激素治疗重症格林-巴利综合征可缩短病程、缓解急性期症状。 相似文献
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Gregory P. Giambrone Shelley M. Zansky Millicent Eidson Pamela G. Duncan Louise-Anne McNutt Guthrie S. Birkhead 《Emerging infectious diseases》2013,19(12):1956-1962
The New York State Department of Health (NYSDOH) collected information about hospitalized patients with Guillain-Barré syndrome (GBS) during October 2009–May 2010, statewide (excluding New York City), to examine a possible relationship with influenza A(H1N1)pdm09 vaccination. NYSDOH established a Clinical Network of neurologists and 150 hospital neurology units. Hospital discharge data from the Statewide Planning and Research Cooperative System (SPARCS) were used to evaluate completeness of reporting from the Clinical Network. A total of 140 confirmed or probable GBS cases were identified: 81 (58%) from both systems, 10 (7%) from Clinical Network only, and 49 (35%) from SPARCS-only. Capture–recapture methods estimated that 6 cases might have been missed by both systems. Clinical Network median reporting time was 12 days versus 131 days for SPARCS. In public health emergencies in New York State, a Clinical Network may provide timely data, but in our study such data were less complete than traditional hospital discharge data. 相似文献
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目的 通过分析围产期孕妇生殖道B族链球菌(GBS)的感染和耐药性及不良妊娠结局,为临床医师制定有效的预防和治疗措施提供依据.方法 2013年1月至2015年2月,对795例围产期孕妇生殖道分泌物进行GBS培养鉴定与药敏试验,并观察临床症状及不良妊娠结局,对结果进行统计学分析.结果 795例孕妇中共检出GBS携带者256例,带菌率为32.2%.<30岁组(28.9%)与≥30岁组(42.3%)的带菌率差异具有统计学意义(x2=19.095,P<0.01).GBS阳性者与GBS阴性者的临床症状发生率(18.8% vs 8.0%)差异具有统计学意义(x 2=39.514,P< 0.01).10种抗菌药物(万古霉素、利奈唑胺、青霉素、氨苄西林、头孢曲松、呋喃妥因、左氧氟沙星、克林霉素、红霉素及四环素)耐药率分别为:0%、0%、0.6%、3.1%、6.6%、9.6%、21.9%、23.8%、29.9%及58.1%.D-抑菌圈试验阳性率为23.9%.GBS阳性组与GBS阴性组比较,胎膜早破、早产、宫内感染及新生儿感染发生率的差异均有统计学意义(P<0.01).结论 该区围产期孕妇GBS带菌率较高,且高龄者易于感染;围产期孕妇感染GBS可增加不良妊娠结局的发生,应据药敏试验结果选择敏感性抗生素予以临床干预. 相似文献
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目的:研究丙种球蛋白联合甲泼尼松龙治疗小儿吉兰-巴雷综合征(GBS )呼吸肌麻痹的临床疗效,企为临床治疗此病提供更有效的方法。方法:从在我院进行治疗的小儿GBS呼吸肌麻痹患者中,选取64例患者,并签订知情协议书。按照是否具有使用丙种球蛋白治疗的经济能力将患者分为实验组和对照组。实验组使用丙种球蛋白联合甲泼尼松龙治疗,对照组单纯使用甲泼尼松龙治疗,分别观察两组患者的休斯(H ug hes )评分、疗效和不良反应。结果:试验组患者治疗的有效率为94%,显著高于对照组的69%( P=0.010);在患者接受治疗后15 d ,试验组患者的 H ug hes评分是(2.69±1.23)分,明显低于对照组患者(3.34±0.85)分(P=0.017),且在患者接受治疗后6个月时,实验组患者的H ug hes评分是(1.29±0.94)分,亦明显低于对照组患者的(1.87±0.76)分( P=0.028);实验组不良反应的发生率为16%,而对照组不良反应的发生率为22%( P=0.522),差异不具有统计学意义。结论:与单纯使用甲泼尼松龙治疗小儿GBS呼吸肌麻痹相比,使用丙种球蛋白联合甲泼尼松龙治疗的疗效更为显著,且安全性较高,有利于患者病情的早期康复。 相似文献
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Clare L. Cutland Stephanie J. Schrag Michael C. Thigpen Sithembiso C. Velaphi Jeannette Wadula Peter V. Adrian Locadiah Kuwanda Michelle J. Groome Eckhart Buchmann Shabir A. Madhi 《Emerging infectious diseases》2015,21(4):638-645
Although group B Streptococcus (GBS) is a leading cause of severe invasive disease in young infants worldwide, epidemiologic data and knowledge about risk factors for the disease are lacking from low- to middle-income countries. To determine the epidemiology of invasive GBS disease among young infants in a setting with high maternal HIV infection, we conducted hospital-based surveillance during 2004–2008 in Soweto, South Africa. Overall GBS incidence was 2.72 cases/1,000 live births (1.50 and 1.22, respectively, among infants with early-onset disease [EOD] and late-onset [LOD] disease). Risk for EOD and LOD was higher for HIV-exposed than HIV-unexposed infants. GBS serotypes Ia and III accounted for 84.0% of cases, and 16.9% of infected infants died. We estimate that use of trivalent GBS vaccine (serotypes Ia, Ib, and III) could prevent 2,105 invasive GBS cases and 278 deaths annually among infants in South Africa; therefore, vaccination of all pregnant women in this country should be explored. 相似文献
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Amanda F. Dempsey Jennifer Pyrzanowski Meghan Donnelly Sarah Brewer Juliana Barnard Brenda L. Beaty Sara Mazzoni Sean T. O’Leary 《Vaccine》2014
Objective
Group B Streptococcus (GBS) causes significant infant morbidity and mortality. Promising GBS vaccines are currently in clinical trials. Because GBS vaccines would be the first to specifically target pregnant women, we sought to assess acceptability of a hypothetical GBS vaccine.Study design
We performed an internet survey among currently pregnant or recently delivered women receiving care at one of 9 Ob/Gyn practices in Colorado. Vaccine acceptability was assessed using questions based on constructs from the Health Belief Model. Multivariable analyses assessed the characteristics associated with GBS vaccine acceptability during the current/recent pregnancy.Results
The response rate was 50% (n = 231). While 78% agreed that a GBS vaccine would be a good way to protect newborns, 90% and 83% agreed, respectively, that they worried generally about the safety and effectiveness of new vaccines. Moreover, 39% believed it is generally dangerous for pregnant women to get vaccines. Seventy nine percent ‘definitely’ or ‘probably’ would have gotten a GBS vaccine in their most recent pregnancy if available. The most influential factors associated with this outcome were a strong belief in the vaccine's benefits (adjusted odds ratio [AOR] 6.37, 95% confidence interval [CI] 2.01–20.16), and low perceived barriers to vaccination (AOR 0.11, 95% CI (0.03–0.37)).Conclusion
A GBS vaccine may be acceptable to pregnant women but would benefit from strong provider support and education about the risks and consequences of GBS infection and the benefits to vaccination. 相似文献9.
K.Kvist Christensen K. Dahlander V. Lindén N. Svenningsen P. Christensen 《European journal of obstetrics, gynecology, and reproductive biology》1981,12(3):143-150
Among 22 mothers of infants infected with group B streptococci (GBS), 19 showed markedly low levels of antibodies against the infecting type. Three of the patients with low antibody levels went through a new pregnancy within 1 yr after they had lost an infant (2 patients) or experienced fetal death due to GBS (1 patient). They were still urogenital carriers of the type of GBS causing the previous infection, and their serum levels of type-specific antibodies remained low. All three went through a successful pregnancy following a prevention program comprising antibiotic treatment from the 28th wk of pregnancy. 相似文献
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van Doorn PA 《Journal of the peripheral nervous system : JPNS》2005,10(2):113-127
Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating poly-(radiculo)neuropathy (CIDP) are immune-mediated disorders with a variable duration of progression and a range in severity of weakness. Infections can trigger GBS and exacerbate CIDP. Anti-ganglioside antibodies are important, but there is debate on the role of genetic factors in the pathogenesis of these disorders. Randomized controlled trials (RCT) have shown that intravenous immunoglobulin (IVIg) and plasma exchange (PE) are effective in both GBS and CIDP. Most CIDP patients also improve after steroid therapy. Despite current treatment options, many patients have residual deficits or need to be treated for a long period of time. Therefore, new treatment trials are highly indicated. This review focuses on the current and possible new treatment options that could be guided by recent results from laboratory experiments. 相似文献