全文获取类型
收费全文 | 29977篇 |
免费 | 2651篇 |
国内免费 | 77篇 |
学科分类
医药卫生 | 32705篇 |
出版年
2023年 | 283篇 |
2022年 | 184篇 |
2021年 | 1063篇 |
2020年 | 670篇 |
2019年 | 1024篇 |
2018年 | 1101篇 |
2017年 | 762篇 |
2016年 | 801篇 |
2015年 | 1005篇 |
2014年 | 1298篇 |
2013年 | 1648篇 |
2012年 | 2373篇 |
2011年 | 2383篇 |
2010年 | 1295篇 |
2009年 | 1054篇 |
2008年 | 1650篇 |
2007年 | 1659篇 |
2006年 | 1567篇 |
2005年 | 1436篇 |
2004年 | 1279篇 |
2003年 | 1128篇 |
2002年 | 984篇 |
2001年 | 404篇 |
2000年 | 330篇 |
1999年 | 343篇 |
1998年 | 188篇 |
1997年 | 156篇 |
1996年 | 155篇 |
1995年 | 147篇 |
1994年 | 120篇 |
1993年 | 120篇 |
1992年 | 260篇 |
1991年 | 218篇 |
1990年 | 202篇 |
1989年 | 204篇 |
1988年 | 198篇 |
1987年 | 174篇 |
1986年 | 163篇 |
1985年 | 153篇 |
1984年 | 148篇 |
1983年 | 160篇 |
1982年 | 136篇 |
1981年 | 124篇 |
1980年 | 113篇 |
1979年 | 136篇 |
1978年 | 115篇 |
1976年 | 115篇 |
1975年 | 105篇 |
1974年 | 101篇 |
1973年 | 113篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
3.
4.
Greer Hunter R. Miller Kristen Samay Sadaf Nellan Anandani Green Adam L. 《Journal of neuro-oncology》2022,159(2):301-308
Journal of Neuro-Oncology - The role of white blood cells (WBC) in the pediatric central nervous system (CNS) tumor microenvironment is incompletely defined. We hypothesized that the WBC profile in... 相似文献
5.
Ha Audrey Y. Do Bao H. Bartret Adam L. Fang Charles X. Hsiao Albert Lutz Amelie M. Banerjee Imon Riley Geoffrey M. Rubin Daniel L. Stevens Kathryn J. Wang Erin Wang Shannon Beaulieu Christopher F. Hurt Brian 《Journal of digital imaging》2022,35(3):524-533
Journal of Digital Imaging - Scoliosis is a condition of abnormal lateral spinal curvature affecting an estimated 2 to 3% of the US population, or seven million people. The Cobb angle is the... 相似文献
6.
Moreira Daniel C. Venkataraman Sujatha Subramanian Apurva Desisto John Balakrishnan Ilango Prince Eric Pierce Angela Griesinger Andrea Green Adam Eberhardt Charles G. Foreman Nicholas K. Vibhakar Rajeev 《Journal of neuro-oncology》2020,147(3):531-545
Journal of Neuro-Oncology - MYC-driven medulloblastomas are highly aggressive childhood tumors with dismal outcomes and a lack of new treatment paradigms. We identified that targeting replication... 相似文献
7.
Achim Rosemann Adam Balen Brigitte Nerlich Christine Hauskeller Margaret Sleeboom‐Faulkner Sarah Hartley Xinqing Zhang Nick Lee 《The Hastings Center report》2019,49(3):30-42
A central problem for the international governance of heritable germline gene editing is that there are important differences in attitudes and values as well as ethical and health care considerations around the world. These differences are reflected in a complicated and diverse regulatory landscape. Several publications have discussed whether reproductive uses would be legally permissible in individual countries and whether clinical applications could emerge in the context of regulatory gaps and gray areas. Systematic comparative studies that explore issues related to the governance of this technology from different national and international perspectives are needed to address the lack of knowledge in this area. In this research report, we contribute to filling this gap by presenting views of stakeholders in the United Kingdom on challenges to the governance of heritable genome editing. We present findings from a multistakeholder study conducted in the United Kingdom between October 2016 and January 2018 and funded by the Wellcome Trust. This research included interviews, literature analysis, and a workshop. We involved leading U.K. scientists, in vitro fertilization clinicians, and representatives from regulatory bodies, patient organizations, and other civil societal organizations, as well as fertility companies. Part one of this article explores stakeholder perceptions of possible global developments in heritable genome editing and associated risks and governance challenges. Part two presents a range of policy options that were generated during the workshop in relation to the challenges discussed in part one. 相似文献
8.
Adam Wagstaff 《Health economics》2019,28(6):765-781
In the “basic” approach, medical expenses are catastrophic if they exceed a prespecified percentage of consumption or income; the approach tells us if expenses cause a large percentage reduction in living standards. The ability‐to‐pay (ATP) approach defines expenses as catastrophic if they exceed a prespecified percentage of consumption less expenses on nonmedical necessities or an allowance for them. The paper argues that the ATP approach does not tell us whether expenses are large enough to undermine a household's ability to purchase nonmedical necessities. The paper compares the income‐based and consumption‐based variants of the basic approach, and shows that if the individual is a borrower after a health shock, the income‐based ratio will exceed the consumption‐based ratio, and both will exceed the more theoretically correct Flores et al. ratio; whereas if the individual continues to be a saver after a health shock, the ordering is reversed and the income‐based ratio may not overestimate Flores et al.'s ratio. Last, the paper proposes a lifetime money metric utility (LMMU) approach defining medical expenses as catastrophic in terms of their lifetime consequences. Under certain assumptions, the LMMU and Flores et al. approaches are identical, and neither requires data on how households finance their medical expenses. 相似文献
9.
10.
Adam Hermawan Herwandhani Putri Rohmad Yudi Utomo 《Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences》2020,28(2):685
BackgroundThe survival rate of patients with pancreatic cancer is low; therefore, continuous discovery and development of novel pancreatic cancer drugs are required. Functional network analysis is an integrated bioinformatics approach based on gene, target, and disease networks interaction, and it is extensively used in drug discovery and development.ObjectiveThis study aimed to identify if atenolol, a selective adrenergic inhibitor, can be repurposed for the treatment of pancreatic cancer using functional network analysis.MethodsDirect target proteins (DTPs) and indirect target proteins (ITPs) were obtained from STITCH and STRING databases, respectively. Atenolol-mediated proteins (AMPs) were collected from DTPs and ITPs and further analyzed for gene ontology, KEGG pathway enrichment, genetic alterations, overall survival, and molecular docking.ResultsWe obtained 176 AMPs that consisted of 10 DTPs and 166 ITPs. Among the AMPs involved in the pancreatic cancer pathways, several AMPs such as MAPK1, RELA, MAPK8, STAT1, and STAT3 were identified. Genetic alterations in seven AMPs were identified in 0.9%–16% of patients. Patients with high mRNA levels of MAPK1, RELA, STAT3, GNB1, and MMP9 had significantly worse overall survival rates compared with patients with low expression. Molecular docking studies showed that RELA and MMP9 are potential target candidates of atenolol in the treatment of patients with pancreatic cancer.ConclusionIn conclusion, atenolol can potentially be repurposed to target pancreatic cancer cells by modulating MMP9 and NF-κB signaling. The results of this study need to be further validated in vitro and in vivo.Graphical abstractElectronic supplementary materialThe online version of this article (10.1007/s40199-020-00375-4) contains supplementary material, which is available to authorized users. 相似文献