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1.
Dolhen Pierre Lipski Samuel Touijar Rachid Van Bogaert Juliette 《European archives of oto-rhino-laryngology》2020,277(3):715-725
European Archives of Oto-Rhino-Laryngology - The BAHA (bone-anchored hearing aid) Attract is a magnetic transcutaneous bone conduction device anchored into the temporal bone. The standard surgical... 相似文献
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Garel Juliette Blondiaux Eléonore Della Valle Valeria Guilbaud Lucie Khachab Farah Jouannic Jean-Marie Ducou le Pointe Hubert Garel Catherine 《Pediatric radiology》2020,50(4):575-582
A wide range of genitourinary pathologies can be diagnosed in utero, from a simple vesicoureteral reflux to a more complex disorder of sexual differentiation. The prognosis and neonatal management of these conditions differ significantly. Evaluation of the fetal perineal anatomy is paramount to making the right diagnosis. The aim of this pictorial essay is to show sonographers how to acquire a perineal midsagittal view in a male fetus, and to demonstrate how this specific view allows assessment of the urethra and penis, to differentiate various genitourinary pathologies.
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Laurence Veracini Dominique Grall Sébastien Schaub Stéphanie Beghelli-de la Forest Divonne Marie-Christine Etienne-Grimaldi Gérard Milano Alexandre Bozec Emmanuel Babin Anne Sudaka Juliette Thariat Ellen Van Obberghen-Schilling 《Oncotarget》2015,6(10):7570-7583
EGF receptor (EGFR) overexpression is thought to drive head and neck carcinogenesis however clinical responses to EGFR-targeting agents have been modest and alternate targets are actively sought to improve results. Src family kinases (SFKs), reported to act downstream of EGFR are among the alternative targets for which increased expression or activity in epithelial tumors is commonly associated to the dissolution of E-cadherin-based junctions and acquisition of a mesenchymal-like phenotype. Robust expression of total and activated Src was observed in advanced stage head and neck tumors (N=60) and in head and neck squamous cell carcinoma lines. In cultured cancer cells Src co-localized with E-cadherin in cell-cell junctions and its phosphorylation on Y419 was both constitutive and independent of EGFR activation. Selective inhibition of SFKs with SU6656 delocalized E-cadherin and disrupted cellular junctions without affecting E-cadherin expression and this effect was phenocopied by knockdown of Src or Yes. These findings reveal an EGFR-independent role for SFKs in the maintenance of intercellular junctions, which likely contributes to the cohesive invasion E-cadherin-positive cells in advanced tumors. Further, they highlight the need for a deeper comprehension of molecular pathways that drive collective cell invasion, in absence of mesenchymal transition, in order to combat tumor spread. 相似文献
5.
AbstractBackground: The evolution of surgical practice may lead to increasing difficulties for surgeons to perform fundamental research. The aim of this study was to evaluate the expectations and the challenges encountered by young surgeons when starting basic science.Methods: A qualitative study was conducted in France. A written questionnaire was anonymously filled by the participants attending to the Master Degree in surgical science.Results: The study included 47 participants (median age: 28 years, 59.6% of men); 37 (78.7%) participants had applied for a grant for their salary and 32 (68.1%) had obtained it. Nine (19.1%) participants had planned to keep their usual clinical activity. The main motivations were the perspective to embark on an academic career (55.3%) and improvement of knowledge in science (38.3%). The main barriers encountered were the lack of time (70.2%), the lack of interest (27.7%), the lack of financial support (23.4%) and administrative difficulties (12.8%).Conclusion: This study identified main barriers that young surgeons have to face when getting involved in basic science underlining the need to improve institutional and financial support to ensure involvement of new generations of surgeons in surgical research. 相似文献
6.
Stéphanie Lejeune Muriel Pichavant Ilka Engelmann Laurent Béghin Elodie Drumez Olivier Le Rouzic Rodrigue Dessein Stéphanie Rogeau Timothée Beke Gwenola Kervoaze Céline Delvart Héloïse Ducoin Guillaume Pouessel Armelle Le Mée Sophie Boileau Juliette Roussel Cécile Bonnel Clémence Mordacq Caroline Thumerelle Philippe Gosset Antoine Deschildre 《Pediatric allergy and immunology》2020,31(6):651-661
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Eugen Dhimolea Ricardo de Matos Simoes Dhvanir Kansara Aziz Al’Khafaji Juliette Bouyssou Xiang Weng Shruti Sharma Joseline Raja Pallavi Awate Ryosuke Shirasaki Huihui Tang Brian J. Glassner Zhiyi Liu Dong Gao Jordan Bryan Samantha Bender Jennifer Roth Michal Scheffer Constantine S. Mitsiades 《Cancer cell》2021,39(2):240-256.e11
9.
Omalizumab discontinuation in children with severe allergic asthma: An observational real‐life study
10.
Alba Grifoni Swapnil Mahajan John Sidney Sheridan Martini Richard H. Scheuermann Bjoern Peters Alessandro Sette 《Human immunology》2019,80(11):923-929
Enteroviruses are potentially linked to the emergence of Acute Flaccid Myelitis (AFM), a rare but very serious condition that affects the nervous system. AFM has been associated with coxsackievirus A16, enterovirus A71 (EVA71) and enterovirus D68 (EVD68). Little is known about host-pathogen interactions for these viruses, and whether immune responses may have a protective or immunopathological role in disease presentations. Towards addressing this issue, we used the Immune Epitope Database to assess the known inventory of B and T cell epitopes from enteroviruses, focusing on data related to human hosts. The extent of conservation in areas that are targets of B and T cell immune responses were examined. This analysis sheds light on regions of the enterovirus polypeptide that can be probed to induce a specific or cross-reactive B or T cell the immune response to enteroviruses, with a particular focus on coxsackievirus A16, EVA71 and EVD68. In addition, these analyses reveal the current gap-of-knowledge in the T and B cell immune responses that future studies should aim to address. 相似文献