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Preuss SF Dinh V Klussmann JP 《中国口腔颌面外科杂志》2008,6(1):58-58
口咽鳞癌的临床处理仍存在争议,该文对口咽癌患者应用原发灶手术切除、颈淋巴清扫及术后行放疗的效果进行总结。对复合标准的211例患者进行回顾性研究。应用Kaplan—Meier曲线计算总生存率及无瘤生存率,应用单变量及多变量统计学分析研究疾病的临床特点与预后的关系。2年及5年的无瘤生存率分别为79.8%和68.8%.单因素分析表明,肿瘤切缘阳性是无瘤生存率重要也是唯一的预后因素。 相似文献
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Background
Scotland has high levels of untreated dental caries in primary teeth. The Hall Technique is a simplified method of managing carious primary molars using preformed metal crowns (PMCs) cemented with no local anaesthesia, caries removal or tooth preparation. This study compared the acceptability of the Hall Technique for children, their carers, and dentists, and clinical outcomes for the technique, with conventional restorations. 相似文献4.
Injuries to peripheral nerves are common and cause life-changing problems for patients alongside high social and health care costs for society. Current clinical treatment of peripheral nerve injuries predominantly relies on sacrificing a section of nerve from elsewhere in the body to provide a graft at the injury site. Much work has been done to develop a bioengineered nerve graft, precluding sacrifice of a functional nerve. Stem cells are prime candidates as accelerators of regeneration in these nerve grafts. This review examines the potential of adipose-derived stem cells to improve nerve repair assisted by bioengineered nerve grafts. 相似文献
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Lieke S Kamphuis Femke Bonte‐Mineur Jan A van Laar P Martin van Hagen Paul L van Daele 《Journal of bone and mineral research》2014,29(11):2498-2503
Granulomas in sarcoidosis express high levels of 1α‐hydroxylase, an enzyme that catalyzes the hydroxylation of 25‐OH vitamin D to its active form, 1,25(OH)2 vitamin D. Overproduction of 1α‐hydroxylase is held responsible for the development of hypercalcemia in sarcoidosis patients. Corticosteroids are used as first‐line treatment in organ‐threatening sarcoidosis. In this light, osteoporosis prevention with calcium and vitamin D (CAD) supplementation is often warranted. However, sarcoidosis patients are at risk for hypercalcemia, and CAD supplementation affects the calcium metabolism. We studied calcium and vitamin D disorders in a large cohort of sarcoidosis patients and investigated if CAD supplementation is safe. Retrospectively, data of 301 sarcoidosis patients from July 1986 to June 2009 were analyzed for serum calcium, 25‐hydroxy vitamin D (25‐(OH)D), 1,25‐dihydroxy vitamin D (1,25(OH)2D), and use of CAD supplementation. Disease activity of sarcoidosis was compared with serum levels of vitamin D. Hypercalcemia occurred in 8%. A significant negative correlation was found between 25‐(OH)D and disease activity of sarcoidosis measured by somatostatin receptor scintigraphy. In our study, 5 of the 104 CAD‐supplemented patients developed hypercalcemia, but CAD supplementation was not the cause of hypercalcemia. Patients without CAD supplementation were at higher risk for developing hypercalcemia. During CAD supplementation, no hypercalcemia developed as a result of supplementation. Hypovitaminosis D seems to be related with more disease activity of sarcoidosis and, therefore, could be a potential risk factor for disease activity of sarcoidosis. Thus, vitamin D–deficient sarcoidosis patients should be supplemented. © 2014 American Society for Bone and Mineral Research. 相似文献
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Hyperbaric oxygen therapy improves angiogenesis and bone formation in critical sized diaphyseal defects 下载免费PDF全文
JP Grassmann J Schneppendahl AR Hakimi M Herten M Betsch TT Lögters S Thelen M Sager M Wild J Windolf P Jungbluth M Hakimi 《Journal of orthopaedic research》2015,33(4):513-520
Besides the use of autologous bone grafting several osteoconductive and osteoinductive methods have been reported to improve bone healing. However, persistent non‐union occurs in a considerable number of cases and compromised angiogenesis is suspected to impede bone regeneration. Hyperbaric oxygen therapy (HBO) improves angiogenesis. This study evaluates the effects of HBO on bone defects treated with autologous bone grafting in a bone defect model in rabbits. Twenty‐four New‐Zealand White Rabbits were subjected to a unilateral critical sized diaphyseal radius bone defect and treated with autologous cancellous bone transplantation. The study groups were exposed to an additional HBO treatment regimen. Bone regeneration was evaluated radiologically and histologically at 3 and 6 weeks, angiogenesis was assessed by immunohistochemistry at three and six weeks. The additional administration of HBO resulted in a significantly increased new bone formation and angiogenesis compared to the sole treatment with autologous bone grafting. These results were apparent after three and six weeks of treatment. The addition of HBO therapy to autologous bone grafts leads to significantly improved bone regeneration. The increase in angiogenesis observed could play a crucial role for the results observed. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:513–520, 2015. 相似文献
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应用扩散张量纤维束成像技术评价弓状束在语言功能及功能障碍预后评估中的作用 总被引:1,自引:0,他引:1
目的:利用磁共振扩散张量成像及扩散张量纤维束成像技术观察正常人及失语症患者弓状束结构特点,探讨弓状束功能解剖学结构基础及其在语言功能障碍康复预后评估中的作用。方法:临床资料的收集和磁共振扫描及分析于2003-11/2005-02在北京天坛医院神经影像中心完成。选择正常人20例,失语症患者48例,其中Broca失语30例,Wernicke失语13例,传导性失语5例。应用德国西门子公司SIEMENS Trio 2003T磁共振仪及工作站完成全脑的数据收集和后处理,观察弓状纤维束的磁共振扩散张量成像部分各向异性(FA)值及纤维束的数量。结果:68例受试者均进入结果分析。①正常人:弓状束左右侧对照差异不显著(P>0.05),个体间的纤维束数量有差异;纤维束平均向异性值左侧高于右侧(P<0.05)。②Broca失语者:弓状束左侧的纤维束数量及纤维束平均FA均较右侧减少(P<0.05),左侧弓状束的平均FA较正常人组减少(P<0.05),其弓状束改变主要是前端纤维束完整性破坏和移位。③Wernicke失语者:弓状束的纤维束数量及纤维束平均FA均较正常人组减少(P<0.05),其弓状束有不同程度损伤,主要是中后部的损伤明显。④传导性失语者:弓状束的损伤主要以功能偏利侧的中部为主,其前、中和后的FA值明显低于正常人组(P<0.05)。结论:①弓状束是联系Broca区及Wernicke区间重要联合纤维束,在语言功能的完成中具有重要的作用,但个体间存在左右侧的数量及结构的差异。②失语症弓状束均有不同程度损伤,损伤部位与失语类型有关,同时弓状束损伤程度与预后密切相关。 相似文献
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Chintamani Jotinder Khanna JP Singh Pranjal Kulshreshtha Pawan Kalra Binita Priyambada RS Mohil Dinesh Bhatnagar 《BMC emergency medicine》2005,5(1):1-8