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1.
Kentaro Matsuo Kohei Taniguchi Hiroki Hamamoto Yosuke Inomata Kazumasa Komura Tomohito Tanaka Sang-Woong Lee Kazuhisa Uchiyama 《Cancer science》2021,112(8):2984-2992
Delta-like canonical Notch ligand 3 (DLL3) is a member of the Delta/Serrate/Lag2 (DSL) Notch receptor ligand family and plays a crucial role in Notch signaling, which influences various cellular processes including differentiation, proliferation, survival, and apoptosis. DLL3 is expressed throughout the presomitic mesoderm and is localized to the rostral somatic compartments; mutations in DLL3 induce skeletal abnormalities such as spondylocostal dysostosis. Recently, DLL3 has attracted interest as a novel molecular target due to its high expression in neuroendocrine carcinoma of the lung. Moreover, a DLL3-targeting Ab-drug conjugate, rovalpituzumab tesirine (ROVA-T), has been developed as a new treatment with proven antitumor activity. However, the development of ROVA-T was suspended because of shorter overall survival compared to topotecan, the second-line standard treatment. Thus, several studies on the mechanism and function of DLL3 in several malignancies are underway to find a new strategy for targeting DLL3. In this review, we discuss the roles of DLL3 in various malignancies and the future perspectives of DLL3-related research, especially as a therapeutic target. 相似文献
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Mizuhashi H Suga K Uchiyama T Oda Y 《International journal of oral and maxillofacial surgery》2008,37(2):162-169
The purpose of this study was to investigate how the characteristics of a poly-l-lactic acid mini-plate changed with dynamic loading in an environment with hydrolytic degradation. A mandible osteosynthesis model was prepared with specimen poly-l-lactic acid mini-plates to simulate sagittal splitting ramus osteotomy. The model was then subjected to dynamic loading, and changes in specimen shape and surface quality were observed. Specimen bending strength was then measured, and degree of hydrolytic degradation estimated. Neither dynamic loading nor degree of load clearly affected degree of hydrolytic degradation. The specimens maintained their original shape and bending strength for up to 4 weeks with dynamic loading of 40 N or less in an environment with hydrolytic degradation. At 8 weeks, under the same conditions, the specimens showed cracks or fractures, or both, together with a clear decrease in bending strength. The results suggest that dynamic loading causes cracking in a poly-l-lactic acid mini-plate, and that growth of these cracks decreases bending strength over time, leading to fatigue fracture. 相似文献
4.
Sakamoto T Ishii T Mukai M Ueki A Sueishi K Suga K Nakano Y Uchiyama T 《The Bulletin of Tokyo Dental College》2011,52(2):103-112
Distraction osteogenesis is widely used for the treatment of craniofacial deformities. In patients with cleft lip and palate, distraction osteogenesis can be employed to repair the alveolar cleft. In this report, we describe the management of three cases of unilateral cleft lip and palate by interdental distraction osteogenesis. Interdental distraction osteogenesis of the maxillary bone was performed to reduce the width of the alveolar cleft in these patients in conjunction with orthodontic treatment. Tooth-tooth type distraction devices were fabricated and delivered at the same time as osteotomy. Distraction was continued until the midline of the dentition coincided with the facial midline, and until the width of the alveolar cleft was reduced to the width of lateral incisor or had closed. One month after distraction was complete, orthodontic treatment with an edgewise appliance was initiated, and neighboring teeth were moved into the newly created bone. A favorable treatment outcome was achieved in all three cases. 相似文献
5.
Miura T Ishihara K Kato T Kimizuka R Miyabe H Ando T Uchiyama T Okuda K 《Oral microbiology and immunology》2005,20(3):167-171
We isolated bacteria from periodontal sites and mixed saliva in eight patients with Behcet's disease and surveyed them to determine whether they produced heat shock proteins (HSPs) and superantigen. Cultivable bacterial compositions from periodontal sites and saliva were examined by anaerobic culture using blood agar plates. Gram-negative anaerobic rods such as Prevotella intermedia, Fusobacterium nucleatum, and Capnocytophaga species were predominant in the isolates from the subgingival plaque samples. The Streptococcus mitis group was the most common type isolated from the saliva samples. To detect the production of HSPs, Western blot analyses were performed using a polyclonal rabbit antibody to Escherichia coli DnaK and a monoclonal antibody to Helicobacter pylori Gro-EL. Sonic extracts of 27 of the strains (79.4%) reacted with the antibody against E. coli DnaK. Nine of these 34 strains (26.5%) were found to produce HSPs that reacted with antibody to H. pylori Gro-EL. A total of 54 isolates were examined for superantigen activity against human peripheral leukocytes. Twenty-five gram-negative clinical strains isolated from chronic periodontitis lesions and 20 ATCC strains of microorganisms were also examined. We could not detect any superantigen activity in 500x diluted supernatant of the strains isolated from the eight patients with Behcet's disease. The present study indicates that the anaerobic strains isolated from the oral cavity of these patients produce HSPs, the production being related to Bechet's disease. 相似文献
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Shumei Murakami D.D.S. Ph.D. Masami Fujishita D.D.S. Ph.D. Akira Takahashi D.D.S. Ph.D. Hideyoshi Nishiyama D.D.S. Yuka Uchiyama D.D.S. Tadashi Sasai D.D.S. Hajime Fuchihata D.D.S. Ph.D. 《Oral Radiology》1993,9(1):41-47
For patients with TMJ dysfunction, operators often change the condylar position by various methods. The aim of this study
is to investigate how much the changes with time of condylar positions are related to the changes of clinical signs.
The subjects were 584 joints of 127 patients with TMJ dysfunction to whom the serial lateral TMJ tomography was performed
more than twice.
In the most of cases where the condylar position had moved downward, inter-incisal distance had increased and TMJ noise had
ameliorated. Furthermore, in many cases where the condylar position had moved forward, the amelioration of the TMJ pain was
observed.
It was considered that those ameliorations occurred because the positional relationship between the condylar head and the
articular disk or posterior attachment had been improved. 相似文献
9.
Y Mutoh Y Ohashi N Uchiyama K Terada K Hanada F Sasaki 《Journal of cranio-maxillo-facial surgery》1991,19(2):49-55
Three-dimensional surface reconstruction imaging from CT scans was used to study the deformity of the mandible in six patients with mandibular asymmetry. High-resolution axial CT scans of the mandible were obtained using Somatom-DR3 (Siemens). COSMOZONE-2SA (Nikon) with PC-9801VX21 (NEC) was used to reconstruct the three-dimensional images. The six patients were divided into two groups. One group was classified as unilateral hybrid forms and the other group was classified hemimandibular elongation on the diagnostic criteria of Obwegeser and Makek (1986). In the three-dimensional surface reconstruction, exact location and the degree of the deformity in the region from the ascending ramus to the condylar head and the lingual aspect from the ascending ramus to the mandibular body were accurately represented. In addition, the three-dimensional images could be easily rotated arbitrarily, precise evaluation could be done at every part of the mandible. On diagnosis, the mandibular morphology classified into the unilateral hybrid forms was presumed to vary from case to case even in the same classification. 相似文献
10.
Takahiro Tomino Hideaki Uchiyama Shinji Itoh Takahiro Higashi Ai Edagawa Akinori Egashira Daihiko Eguchi Hirofumi Kawanaka Toshiroh Okuyama Masahiro Tateishi Daisuke Korenaga Kenji Takenaka 《Surgery today》2014,44(4):690-695