全文获取类型
收费全文 | 9539篇 |
免费 | 432篇 |
国内免费 | 38篇 |
学科分类
医药卫生 | 10009篇 |
出版年
2023年 | 38篇 |
2022年 | 37篇 |
2021年 | 153篇 |
2020年 | 91篇 |
2019年 | 124篇 |
2018年 | 174篇 |
2017年 | 133篇 |
2016年 | 131篇 |
2015年 | 144篇 |
2014年 | 167篇 |
2013年 | 253篇 |
2012年 | 382篇 |
2011年 | 416篇 |
2010年 | 254篇 |
2009年 | 251篇 |
2008年 | 458篇 |
2007年 | 486篇 |
2006年 | 479篇 |
2005年 | 519篇 |
2004年 | 538篇 |
2003年 | 571篇 |
2002年 | 528篇 |
2001年 | 299篇 |
2000年 | 302篇 |
1999年 | 274篇 |
1998年 | 152篇 |
1997年 | 131篇 |
1996年 | 95篇 |
1995年 | 95篇 |
1994年 | 99篇 |
1993年 | 104篇 |
1992年 | 209篇 |
1991年 | 192篇 |
1990年 | 190篇 |
1989年 | 197篇 |
1988年 | 157篇 |
1987年 | 146篇 |
1986年 | 115篇 |
1985年 | 128篇 |
1984年 | 97篇 |
1983年 | 81篇 |
1982年 | 46篇 |
1981年 | 49篇 |
1980年 | 46篇 |
1979年 | 78篇 |
1978年 | 49篇 |
1977年 | 47篇 |
1976年 | 34篇 |
1975年 | 31篇 |
1974年 | 51篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
1.
A case of bullous pemphigoid associated with psoriasis vulgaris showing Hailey–Hailey disease‐like histopathological changes in regenerated epidermis without genomic mutation in ATP2C1 or ATP2A2 gene 下载免费PDF全文
2.
Daisuke Ishibashi Takeshi Ishikawa Satoshi Mizuta Hiroya Tange Takehiro Nakagaki Tsuyoshi Hamada Noriyuki Nishida 《Neurotherapeutics》2020,17(4):1836
The accumulation of abnormal prion protein (PrPSc) produced by the structure conversion of PrP (PrPC) in the brain induces prion disease. Although the conversion process of the protein is still not fully elucidated, it has been known that the intramolecular chemical bridging in the most fragile pocket of PrP, known as the “hot spot,” stabilizes the structure of PrPC and inhibits the conversion process. Using our original structure-based drug discovery algorithm, we identified the low molecular weight compounds that predicted binding to the hot spot. NPR-130 and NPR-162 strongly bound to recombinant PrP in vitro, and fragment molecular orbital (FMO) analysis indicated that the high affinity of those candidates to the PrP is largely dependent on nonpolar interactions, such as van der Waals interactions. Those NPRs showed not only significant reduction of the PrPSc levels but also remarkable decrease of the number of aggresomes in persistently prion-infected cells. Intriguingly, treatment with those candidate compounds significantly prolonged the survival period of prion-infected mice and suppressed prion disease-specific pathological damage, such as vacuole degeneration, PrPSc accumulation, microgliosis, and astrogliosis in the brain, suggesting their possible clinical use. Our results indicate that in silico drug discovery using NUDE/DEGIMA may be widely useful to identify candidate compounds that effectively stabilize the protein.Electronic supplementary materialThe online version of this article (10.1007/s13311-020-00903-9) contains supplementary material, which is available to authorized users. 相似文献
3.
4.
5.
6.
7.
8.
9.
We studied two patients with nonfamilial olivopontocerebellar atrophy with skeletal myoclonus. Palatal or skeletal myoclonus is probably not a coincidental finding but another manifestation of the underlying disease. In both cases, the myoclonus was suppressed by administration of trihexyphenidyl, indicating a cholinergic disorder. 相似文献
10.