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1.
Soluble B7‐H4 blood serum levels are elevated in women at high risk for preeclampsia in the first trimester,as well as in patients with confirmed preeclampsia 下载免费PDF全文
Pawel Mach Luisa Nolte‐Boenigk Leonie Droste Laura Fox Mirjam Frank Boerge Schmidt Florian Herse Stefan Verlohren Lukasz Wicherek Antonella Iannaccone Cahit Birdir Dimitrios Andrikos Rainer Kimmig Alexandra Gellhaus Angela Köninger 《American journal of reproductive immunology (New York, N.Y. : 1989)》2018,80(3)
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Isabella Nicácio de Freitas Fábio Guilherm Caserta Maryssael de Campos Venancio Avancini Ferreira Alves Juliana Magalh?es Cavalcante Dirce Carraro Renata de Almeida Coudry Márcio Augusto Diniz Sérgio Carlos Nahas Ulysses Ribeiro Jr 《Journal of gastrointestinal oncology.》2015,6(6):628-637
Background
Lynch syndrome (LS) diagnosis is underestimated, and most of the patients remain undetected after colorectal resections. The study aims to assess the frequency of LS in patients undergoing surgical treatment for colorectal cancer (CRC).Methods
A total of 458 CRC patients were operated from January 2005 to December 2008. Positive CRC family history (FH) was present in 118 (25.8%) patients. Histologic sections were reviewed for microsatellite instability (MSI) criteria (Bethesda guidelines), immunohistochemical (IHC) analysis for MLH1, MSH2, MSH6, PMS2 proteins, through the avidin-biotin-peroxidase complex, MSI (BAT-25, BAT-26, NR-21, NR-24 and MONO-27) and BRAF somatic mutation.Results
Of the 118 patients with FH, 61 (51.69%) met at least one of the revised Bethesda criteria. IHC was abnormal in 8 (13.1%) and MSI in 12 patients (20%). BRAF was negative in all cases. MSI histopathological included: intratumoral lymphocytes (47.5%), expansive tumors (29.5%) mucinous component (27.8%) and Crohn’s like reaction in (14.7%). There was an association between the revised Bethesda criteria with: sex, mucinous histology and Crohn’s like reaction; MSI and IHC with PMS2 and MLH1. Revised Bethesda criteria 4 had 10.6 increased chances to display positive MSI. We have proposed a score to contribute as a practical tool in the diagnosis of LS.Conclusions
The frequence of LS in resected CRC patients was 2.6%. The criterion 4 Revised Bethesda was associated more strongly with the presence of MSI. 相似文献4.
Potential challenges facing distributed leadership in health care: evidence from the UK National Health Service 下载免费PDF全文
Graeme Martin Nic Beech Robert MacIntosh Stacey Bushfield 《Sociology of health & illness》2015,37(1):14-29
The discourse of leaderism in health care has been a subject of much academic and practical debate. Recently, distributed leadership (DL) has been adopted as a key strand of policy in the UK National Health Service (NHS). However, there is some confusion over the meaning of DL and uncertainty over its application to clinical and non‐clinical staff. This article examines the potential for DL in the NHS by drawing on qualitative data from three co‐located health‐care organisations that embraced DL as part of their organisational strategy. Recent theorising positions DL as a hybrid model combining focused and dispersed leadership; however, our data raise important challenges for policymakers and senior managers who are implementing such a leadership policy. We show that there are three distinct forms of disconnect and that these pose a significant problem for DL. However, we argue that instead of these disconnects posing a significant problem for the discourse of leaderism, they enable a fantasy of leadership that draws on and supports the discourse. 相似文献
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Sudhakar Selvaraj Osamu Abe Francesco Amico Yuqi Cheng Sean J. Colloby John T. O'Brien Thomas Frodl Ian H. Gotlib Byung-Joo Ham M Justin Kim P Cédric MP Koolschijn Cintia A.‐M. Périco Giacomo Salvadore Alan J. Thomas Marie‐José Van Tol Nic J.A. van der Wee Dick J. Veltman Gerd Wagner Andrew M. McIntosh 《Human brain mapping》2016,37(4):1393-1404
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Dissociable relations between amygdala subregional networks and psychopathy trait dimensions in conduct‐disordered juvenile offenders 下载免费PDF全文
Moji Aghajani Olivier F. Colins Eduard T. Klapwijk Ilya M. Veer Henrik Andershed Arne Popma Nic J. van der Wee Robert R.J.M. Vermeiren 《Human brain mapping》2016,37(11):4017-4033
Psychopathy is a serious psychiatric phenomenon characterized by a pathological constellation of affective (e.g., callous, unemotional), interpersonal (e.g., manipulative, egocentric), and behavioral (e.g., impulsive, irresponsible) personality traits. Though amygdala subregional defects are suggested in psychopathy, the functionality and connectivity of different amygdala subnuclei is typically disregarded in neurocircuit‐level analyses of psychopathic personality. Hence, little is known of how amygdala subregional networks may contribute to psychopathy and its underlying trait assemblies in severely antisocial people. We addressed this important issue by uniquely examining the intrinsic functional connectivity of basolateral (BLA) and centromedial (CMA) amygdala networks in relation to affective, interpersonal, and behavioral traits of psychopathy, in conduct‐disordered juveniles with a history of serious delinquency (N = 50, mean age = 16.83 ± 1.32). As predicted, amygdalar connectivity profiles exhibited dissociable relations with different traits of psychopathy. Interpersonal psychopathic traits not only related to increased connectivity of BLA and CMA with a corticostriatal network formation accommodating reward processing, but also predicted stronger CMA connectivity with a network of cortical midline structures supporting sociocognitive processes. In contrast, affective psychopathic traits related to diminished CMA connectivity with a frontolimbic network serving salience processing and affective responding. Finally, behavioral psychopathic traits related to heightened BLA connectivity with a frontoparietal cluster implicated in regulatory executive functioning. We suggest that these trait‐specific shifts in amygdalar connectivity could be particularly relevant to the psychopathic phenotype, as they may fuel a self‐centered, emotionally cold, and behaviorally disinhibited profile. Hum Brain Mapp 37:4017–4033, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. 相似文献
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‘Wide‐awake drunkenness’? Investigating the association between alcohol intoxication and stimulant use in the night‐time economy 下载免费PDF全文
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Using a thyroid disease‐free population to define the reference interval for TSH and free T4 on the Abbott Architect analyser 下载免费PDF全文
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Tammo A. Brouwer Charina van den Boogaard Eric N. van Roon Cor J. Kalkman Nic Veeger 《Journal of clinical monitoring and computing》2018,32(6):1117-1126
Ultrasound scanning of bladder volume is used for prevention of postoperative urinary retention (POUR). Accurate assessment of bladder volume is needed to allow clinical decision-making regarding the need for postoperative catheterization. Two commonly used ultrasound devices, the BladderScan® BVI 9400 and the newly released Prime® (Verathon Medical®, Bothell, WA, USA), with or without the ‘pre-scan’ option, have not been validated in clinical practice. The aim of this study was to assess the performance of these devices in daily clinical practice. Between June and September 2016 a prospective observational study was conducted in 318 surgical patients (18 years or older) who needed a urinary catheter perioperatively for clinical reasons. For acceptable performance, we required that the volume as estimated by the BladderScan® differs by no more than 5% from the actual urine volume after catheterization. The Schuirmann’s two one-sided test was performed to assess equivalence between the BladderScan® estimate and catheterization. The BVI 9400® overestimated the actual bladder volume by +?17.5% (95% CI +?8.8 to +?26.3%). The Prime® without pre-scan underestimated by ? 4.1% (95% CI ? 8.8 to +?0.5%) and the Prime® with pre-scan underestimated by ? 6.3% (95% CI ? 11.6 to ? 1.1%). This study shows that while both ultrasound devices were able to approximate current bladder volume, both BVI 9400® and Prime®—with and without pre-scan—were not able to measure the actual bladder volume within our predefined limit of ±?5%. Using the pre-scan feature of the Prime® did not further improve accuracy. 相似文献