A Novel Nomogram to Identify Candidates for Extended Pelvic Lymph Node Dissection Among Patients with Clinically Localized Prostate Cancer Diagnosed with Magnetic Resonance Imaging-targeted and Systematic Biopsies

Background

Available models for predicting lymph node invasion (LNI) in prostate cancer (PCa) patients undergoing radical prostatectomy (RP) might not be applicable to men diagnosed via magnetic resonance imaging (MRI)-targeted biopsies.

Congenital isolated midline sinus of the upper lip: clinical and embryological approaches.

OBJECTIVES: Congenital sinuses or fistulas of the lip are uncommon malformations, yet true medial upper-lip fistulas (MULFs) are extremely rare. We present a new case of congenital upper-lip fistula located in the midline of the philtrum of an 8-month-old girl. INTERVENTION: Complete surgical removal was performed with a combined extra- and intraoral approach. Histological examination revealed that the fistula was lined by squamous epithelium with sebaceous and mucous glands and hair follicles. RESULTS: Several embryological hypotheses have been proposed concerning these anomalies. This article reexamines and discusses major embryological theories on pathogenesis of sinuses or fistulas of the upper lip. We propose that early ectodermal inclusion events may occur in the medial fusion area during formation of the intermaxillary process. This embryological approach is highly concordant with our recent hypothesis on nasal dermoid sinus cysts (NDSCs) pathogenesis, in which we proposed an embryological hypothesis with early ectodermal inclusion phenomenon in the midline suture area to explain NDSCs pathogenesis. CONCLUSIONS: Common early ectodermal inclusion phenomena could be involved in both NDSCs and MULFs pathogenesis.     

Contributions of reformatted computed tomography and panoramic radiography in the localization of third molars relative to the maxillary sinus

OBJECTIVE: The aim of this clinical study was to seek an answer to the question of whether CT gives better qualitative and quantitative information as compared to panoramic radiograph when deciding on extraction of upper impacted third molars. STUDY: The study concerned 34 third molars appearing in direct relation with the sinus on the panoramic radiograph for which a CT scan had been recommended. For each case, the panoramic radiograph was compared with the CT scan for 5 evaluation criteria. RESULTS: The CT scan was more precise than the panoramic radiograph by 1.67 mm for measurement of the level of impaction of the third molar, by 12.44 degrees for measurement of the third molar displacement, by 0.74 mm for bone height separating the third molar roots and the sinus, and by 2.26 mm for the length of roots in the sinus. The CT scan was equally accurate for measurement of the distance separating the crowns of second and third molars in 34 cases. CONCLUSIONS: This study confirms the gain in precision for the CT scan as compared with conventional techniques. The CT scan therefore presents advantages when considering the extraction of upper third molars by providing both qualitative and quantitative information liable to bear on the diagnosis and therapeutic management.