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目的探讨改良法经第二三腰椎间隙行腰麻硬膜外联合阻滞(腰硬联合阻滞)对腰麻针置入即刻出现神经刺激症状的发生率和硬膜外导管置入蛛网膜下腔可能性的影响。方法ASAI或Ⅱ级拟行全子宫切除术、经第三四腰椎间隙(L3,4)行腰一硬联合阻滞穿刺失败的患者100例,均改为经第二三腰椎间隙(L2,)进行穿刺。根据穿刺手法不同,随机分为2组:传统方法组(C组)和改良法组(G组)。观察两组腰麻针置入蛛网膜下腔即刻神经刺激症状的发生率和硬膜外导管置入蛛网膜下腔的发生率。结果与C组相比,G组腰麻针置入蛛网膜下腔即刻出现神经刺激症状的发生率和硬膜外导管置入蛛网膜下腔的发生率均降低(P〈0.05),但两组患者术后均未出现任何症状。结论改良法经第二三腰椎间隙行腰硬联合阻滞可降低在该间隙穿刺腰麻针置入蛛网膜下腔即刻出现神经刺激症状的发生率和硬膜外导管置入蛛网膜下腔的发生率,从而可避免脊髓圆锥的损伤。 相似文献
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精氨酸甘氨酸天门冬氨酸序列(RGD)是整合素受体与细胞外配体相结合的识别位点。由于合成的RGD肽具有抑制细胞粘附的作用,所以对眼各种增殖性病变具有潜在的临床应用价值。本文综述了RGD的本质、生物学功能、作用机制和特点,以及RGD肽在眼科中的研究应用。 相似文献
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连续硬膜外麻醉和全身麻醉是目前常用的麻醉方法。由于急性期胆囊胆道手术的老年人往往病情较重,一般状态较差,手术时胆心反射明显,以往多采用连续硬膜外麻醉,但不能有效地控制胆心反射,并加重心率、血压下降,从而影响手术病人的安全性。而全身麻醉能有效控制胆心反射,同时减轻心率、血压的下降,尤其对重症胆囊、胆道感染休克者更适宜。本文就此类病人的麻醉选择、用药、术中血流动力学改变等问题进行分析,探讨不同年龄患者的麻醉方法。 相似文献
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33例角膜血管化高危病人行部分穿透性角膜移植术。对ABO血型相配,供体与受体间交叉配合试验阴性的患者,移植术后发生的免疫排斥反应进行了观察。术后平均随访15个月。结果:33例中有17例发生排斥反应,占51.52%。在此试验正常范围内(1-20%),排斥反应发生率与其值无相关。采用该试验能有效地减少角膜血管化高危病人术后免疫排斥反应。本法不失为简捷、价廉、实用之提高移植成功率的检测手段之一。 相似文献
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Objective To explore the effect of L-canosine in preventing and treating rat cataract induced by sodium selenite. Methods This was an experimental study. Cataract was induced in the rats by sodium selenite. Rats were divided into 3 groups and each group has 3 ones. L-canosine eye drops (50 g/L or 20 g/L) and 0.9% normal saline were respectively instilled to the rat eye for 3 weeks and examined. L-canosine was added to the medium of cultured rat cataract lens at 1.00, 0.10 and 0.01 g/L for 1 week and then examined. Cataract lens were studied by using two-dimensional eletrophoresis. Results One week after instillation of L-canosine, the scores of rat cataract were 2.22±0.65, 2.39±0.98 and 2.83±0.38 in 50 g/L, 20 g/L L-canosine and control groups, respectively. The lesion in 50 g/l, L-canosine group was lighter than that of the control group. There was significant difference between these two groups (P=0.013). On the 2nd and 3rd weeks, there was no difference among these three groups. After 1 week for culturing cataract lens, there was no difference between these three groups. The results of two-dimensional eletrophoresis showed that the protein number was 182 and 161 in the L-carnosine and control groups, respectively. High molecular weight protein decreased and low molecular weight protein increased in L-carnosine group. Conclusions L-carnosine at 50 g/L could restrain the development of early stage rat cataract. L-camosine could modulate the rat lens protein in vitro, but could not affect lens cataract scores. 相似文献
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生长因子与晶体后囊混浊 总被引:2,自引:0,他引:2
随着人工晶体植入术的普遍开展,其远期晶体后囊混浊的研究日益被人们重视。但对生长因子与晶体上皮细胞的关系认识不足。生长因子是一类多功能的分子信号多肽或蛋白质。正常人眼视网膜、玻璃体、房水、晶体上皮细胞等存在数种生长因子。有刺激增殖性及抑制性因子。它们之间需达到平衡状态,否则会引起各种病理改变。本文叙述生长因子的特点,晶体后囊混浊的病理生理及诱因,生长因子与晶体后囊混浊的关系及处理后囊混浊的研究等情况。 相似文献
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