Transcranial direct current stimulation of the prefrontal cortex modulates working memory performance: combined behavioural and electrophysiological evidence

Background  

Transcranial direct current stimulation (tDCS) is a technique that can systematically modify behaviour by inducing changes in the underlying brain function. In order to better understand the neuromodulatory effect of tDCS, the present study examined the impact of tDCS on performance in a working memory (WM) task and its underlying neural activity. In two experimental sessions, participants performed a letter two-back WM task after sham and either anodal or cathodal tDCS over the left dorsolateral prefrontal cortex (DLPFC).     

Frequency- and bias-dependent ac conductivity of charge-density waves in TaS3

The charge-density wave contribution to the dc and the small-signal ac conductivity of orthorhombic TaS₃ has been completely characterized for a single crystal. The ac conductivity is found to be independent of dc bias below threshold. The tunneling theory of charge-density wave depinning successfully predicts the real and imaginary parts of the ac conductivity as functions of both frequency and applied dc bias, using only a fit to the dc I–V data and one adjustable parameter.     

Controlling the electronic coupling between CdSe quantum dots and thiol capping ligands via pH and ligand selection

Comparison of the UV-vis absorption spectra of CdSe quantum dots (QDs) capped with various mercaptocarboxylic acid capping ligands reveals that only 4-mercaptobenzoic acid (MBzA) capping ligands lower the apparent optical band gap. We propose that the delocalization of the excitons in the CdSe QDs is extended onto the ligands via electronic coupling to the π system of the 4-mercaptobenzoic acid molecules through the Cd-S bond. Furthermore, we demonstrate that the electronic coupling between the QDs and the (MBzA) thiol ligands is influenced by the strength of the Cd-S bond that can be changed by protonating the S atom.     

On solving trust-region and other regularised subproblems in optimization

The solution of trust-region and regularisation subproblems that arise in unconstrained optimization is considered. Building on the pioneering work of Gay, Moré and Sorensen, methods that obtain the solution of a sequence of parametrized linear systems by factorization are used. Enhancements using high-order polynomial approximation and inverse iteration ensure that the resulting method is both globally and asymptotically at least superlinearly convergent in all cases, including the notorious hard case. Numerical experiments validate the effectiveness of our approach. The resulting software is available as packages TRS{\tt TRS} and RQS{\tt RQS} as part of the GALAHAD optimization library, and is especially designed for large-scale problems.     

Uncertainties of predictions from parton distributions I: Experimental errors

We determine the uncertainties on observables arising from the errors on the experimental data that are fitted in the global MRST2001 parton analysis. By diagonalizing the error matrix we produce sets of partons suitable for use within the framework of linear propagation of errors, which is the most convenient method for calculating the uncertainties. Despite the potential limitations of this approach we find that it can be made to work well in practice. This is confirmed by our alternative approach of using the more rigorous Lagrange multiplier method to determine the errors on physical quantities directly. As particular examples we determine the uncertainties on the predictions of the charged-current deep-inelastic structure functions, on the cross-sections for W production and for Higgs boson production via gluon-gluon fusion at the Tevatron and the LHC, on the ratio of W^- to W⁺ production at the LHC and on the moments of the non-singlet quark distributions. We discuss the corresponding uncertainties on the parton distributions in the relevant x,Q² domains. Finally, we briefly look at uncertainties related to the fit procedure, stressing their importance and using , and extractions of as examples. As a by-product of this last point we present a slightly updated set of parton distributions, MRST2002. Received: 13 November 2002 / Published online: 5 May 2003 RID="a" ID="a" Royal Society University Research Fellow     

Luminescence of ruthenium halide complexes containing a hemilabile phosphine pyrenyl ether ligand

A series of Ru(II) complexes, tcc-RuX2(POC4Pyr-P,O)2 (X = Cl (3), Br (4), I (5)), containing the hemilabile phosphine pyrenyl ether ligand 4-{2-(diphenylphosphino)phenoxy}butylpyrene (POC4Pyr (1)) are reported. The synthesis and spectroscopic properties of both the ligand, POC4pyr (1), and ligand oxide, P(=O)OC4pyr 2, and the solid-state structure of 1 are reported. Complexes 3-5 react rapidly with CO to give complexes ttt-RuX2(CO)2(POC4pyr-P)2 (X = Cl (6), Br (7), I (8)). No pyrene excimer emission is detected from 3-5; however, different intensities of excimer emission are observed for 6-8. The intensity of excimer emission decreases through the series, with 6 showing the most intense response. The emission is solely due to intramolecular pyrene excimers at low concentrations (< or =10(-4) M). Comparison of the UV-vis and steady-state fluorescence spectra shows overlap between the low energy d-d absorption of 7 and 8 with excimer emission (480 nm), suggesting nonradiative energy transfer may be occurring. Once excess CO is removed, complexes 6-8 isomerize to cis-dicarbonyl complexes cct-RuX2(CO)2(POC4Pyr-P)2 (X = Cl (9), Br (10), I (11)). The intensity of excimer emission from 9-11 increases with respect to the excimer emission observed for 6-8, with 9 showing a significant increase in excimer intensity.