Gas marbles: ultra-long-lasting and ultra-robust bubbles formed by particle stabilization

Bubbles and foams are ubiquitous in daily life and industrial processes. Studying their dynamic behaviors is of key importance for foam manufacturing processes in food packaging, cosmetics and pharmaceuticals. Bare bubbles are inherently fragile and transient; enhancing their robustness and shelf lives is an ongoing challenge. Their rupture can be attributed to liquid evaporation, thin film drainage and the nuclei of environmental dust. Inspired by particle-stabilized interfaces in Pickering emulsions, armored bubbles and liquid marble, bubbles are protected by an enclosed particle-entrapping liquid thin film, and the resultant soft object is termed gas marble. The gas marble exhibits mechanical strength orders of magnitude higher than that of soap bubbles when subjected to overpressure and underpressure, owing to the compact particle monolayer straddling the surface liquid film. By using a water-absorbent glycerol solution, the resulting gas marble can persist for 465 d in normal atmospheric settings. This particle-stabilizing approach not only has practical implications for foam manufacturing processes but also can inspire the new design and fabrication of functional biomaterials and biomedicines.     

Closed form optimal solution of a tuned liquid column damper for suppressing harmonic vibration of structures

Building vibration has become one of the major concerns to structural engineers. Being a vibration absorber, a tuned liquid column damper (TLCD) not only suppresses building vibration, but also acts as the water storage facility of a building. In view of this, the application of such damper is particularly suited for building structures. However, due to inherent nonlinear liquid damping, it is no doubt that a great deal of computational effort is required to search the optimum parameters of TLCD numerically. Therefore, this paper aims to develop a closed form solution scheme of TLCD-structure systems and the optimum parameters of TLCD that lead to the maximum vibration reduction of building structure, so as to facilitate the design of dampers. The developed closed form solution of TLCD-structure system is verified by comparing results obtained from the conventional iterative method. After having a satisfactory verification, the existence of the invariant points of a TLCD-structure system for the case of undamped primary structure is demonstrated. Explicit design formulas of TLCD for the case of undamped primary structures are obtained by optimizing the response at the two invariant points. The optimum parameters of TLCD for the case of damped primary structures are also investigated numerically. An approach for determining the optimum head loss coefficient of TLCD is proposed. Finally, an example is given to illustrate the design procedures of TLCD for suppressing harmonic type vibrations     

ScholOnto: an ontology-based digital library server for research documents and discourse

The internet is rapidly becoming the first place for researchers to publish documents, but at present they receive little support in searching, tracking, analysing or debating concepts in a literature from scholarly perspectives. This paper describes the design rationale and implementation of ScholOnto, an ontology-based digital library server to support scholarly interpretation and discourse. It enables researchers to describe and debate via a semantic network the contributions a document makes, and its relationship to the literature. The paper discusses the computational services that an ontology-based server supports, alternative user interfaces to support interaction with a large semantic network, usability issues associated with knowledge formalisation, new work practices that could emerge, and related work. Published online: 22 September 2000     

Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin

Signals mediated by G-protein-linked receptors display agonist-induced attenuation and recovery involving both protein kinases and phosphatases. The role of protein kinases and phosphatases in agonist-induced attenuation and recovery of beta-adrenergic receptors was explored by two complementary approaches, antisense RNA suppression and co-immunoprecipitation of target elements. Protein phosphatases 2A and 2B are associated with the unstimulated receptor, the latter displaying a transient decrease followed by a 2-fold increase in the levels of association at 30 min following challenge with agonist. Protein kinase A displays a robust, agonist-induced association with beta-adrenergic receptors over the same period. Suppression of phosphatases 2A and 2B with antisense RNA or inhibition of their activity with calyculin A and FK506, respectively, blocks resensitization following agonist removal. Recycling of receptors to the plasma membrane following agonist-promoted sequestration is severely impaired by loss of either phosphatase 2B or protein kinase C. In addition, loss of protein kinase C diminishes association of phosphatase 2B with beta-adrenergic receptors. Overlay assays performed with the RII subunit of protein kinase A and co-immunoprecipitations reveal proteins of the A kinase-anchoring proteins (AKAP) family, including AKAP250 also known as gravin, associated with the beta-adrenergic receptor. Suppression of gravin expression disrupts recovery from agonist-induced desensitization, confirming the role of gravin in organization of G-protein-linked signaling complexes. The Ht31 peptide, which blocks AKAP protein-protein interactions, blocks association of beta-adrenergic receptors with protein kinase A. These data are the first to reveal dynamic complexes of beta-adrenergic receptors with protein kinases and phosphatases acting via an anchoring protein, gravin.     

A novel microstrip ring hybrid incorporating a PBG cell

An experimental investigation of a novel compact microstrip 180° ring hybrid incorporating a one-dimensional (1-D) slow-wave structure, in the form of perforations on the ring itself, is presented. The size of the hybrid is reduced by 23% due to the slow-wave effect, and this size reduction technique has potential applications in MICs and MMICs. The measured insertion loss is comparable to that of a conventional microstrip hybrid     

Apodised technique approach for fibre DFB laser design

An apodised technique, applied in fibre distributed feedback laser design, is presented. With the proposed method, the unidirectional output power from the laser is maximised, and the power accumulation in the phase shift region is simultaneously greatly reduced.     

NOLM-NALM fiber ring laser

We study the bidirectional lightwave propagations in an erbium-doped fiber ring laser and an inverted-S fiber ring laser, and observe their optical bistability behaviors. We develop a model for the inverted-S fiber ring laser using nonlinear optical loop mirror and nonlinear amplifying loop mirror (NOLM-NALM) principle, which operates in the nonlinear region. Good agreements between the laser experimental performance and the developed model are achieved. The laser shows good switching and pulse compression capabilities. In addition, the laser model illustrates the route to chaotic operation via period doubling bifurcation, when the input power increases. We also obtain quasi-periodic operation when the laser is amplitude modulated experimentally.     

Prognostic significance of tumour markers in endometrial cancer

BACKGROUND: Steroid 5 alpha-reductase is implicated in the pathogenesis of benign prostatic hyperplasia (BPH). We studied the in vitro and in vivo effects of FR146687, a new inhibitor of 5 alpha-reductase. METHODS: Two isozymes of rat and human 5 alpha-reductases were expressed in 293 cells. In vivo effects of drugs were evaluated on rat and dog prostates. Castrated immature rats were injected with testosterone propionate (TP) or 5 alpha-dihydrotestosterone propionate (DHTP) to induce growth of the ventral prostates. Testosterone and 5 alpha-dihydrotestosterone (DHT) contents in rat and dog prostates were measured by gas chromatography-mass spectrophotometry (GC-MS). RESULTS: FR146687 showed noncompetitive inhibition in both isozymes and no inhibitory effects on other steroid oxidoreductases. In mature rats and castrated immature rats treated with TP, FR146687 dose-dependently reduced ventral prostate and seminal vesicle weight at doses above 0.1 mg/kg, while castrated immature rats treated with DHTP were not affected by FR146687. FR146687 showed more potent reduction of rat prostates than finasteride. DHT concentration in the prostates was significantly reduced when FR146687 was administered to rats and beagles. CONCLUSIONS: FR146687 is a dual inhibitor for 5 alpha-reductase isozymes and significantly reduced the growth and DHT content in the prostate.     

Towards a local learning (innovation) model of solar photovoltaic deployment

It is by now familiar that in the deployment of solar photovoltaic (PV) systems, the cost dynamics of major system component like solar cell/module is subjected to experience curve effects driven by production learning and research and development at the supplier side. What is less clear, however, is the economics of system integration or system deployment that takes place locally close to the user, involving other market players, in the downstream solar PV value chain. Experts have agreed that suppliers of solar PV system must customize their flexible characteristics to address local unique users’ and applications requirements and compete on price/performance basis. A lack of understanding of the drivers of the economics of system customization therefore is a deficiency in our understanding of the overall economics of this renewable energy technology option.     

A subpopulation of reactive astrocytes at the immediate site of cerebral cortical injury

Data presented in this paper show that bromhexine and its pharmacologically active metabolite can easily be determined by capillary zone electrophoresis. The composition of the running buffer had a significant effect on the reproducibility of the migration time for which a carrier solution containing 30 mM phosphate buffer (pH 3.0), 5 M urea and 10% (v/v) acetonitrile was used. The method was validated with respect to its response linearity and reproducibility. The method is suitable for the determination of bromhexine and ambroxol in several samples such as pharmaceuticals, urine and serum. Photodiode-array detection permitted the rapid identification of both drugs in the sample analyzed.