A NEW OIL SEEPAGE IN THE OMAN MOUNTAINS AND ITS GEOLOGICAL,GEOCHEMICAL AND PETROLEUM SYSTEMS CONTEXT

A minor natural oil seepage is described from an unlikely setting in the Oman Mountains. The host rocks are fractured pelagic limestones of the lower member of the Triassic – Lower Jurassic Matbat Formation of the Hamrat Duru Group in the lower part of the allochthonous Hawasina Complex. This paper summarises Oman's established oil families and documents previously recorded oil seepages as context for describing the new seepage, its geochemistry, and possible source rock. The seep oil is different to those known from Oman's oil fields and probably derived from a poor quality, Mesozoic clastic source rock containing a mix of terrigenous and marine organic matter. The most likely source appears to be the Toarcian turbiditic upper member of the Matbat Formation, equivalent to the clastic Mafraq Formation of the Arabian Platform. The occurrence of source rocks in the allochthonous sediments of the NeoTethyan Hawasina Basin has been suspected previously, though their commercial significance remains to be established.     

MHD mixed convection of a Cu–water nanofluid flow through a channel with an open trapezoidal cavity and an elliptical obstacle

In the current work, numerical simulations are achieved to study the properties and the characteristics of fluid flow and heat transfer of (Cu–water) nanofluid under the magnetohydrodynamic effects in a horizontal rectangular canal with an open trapezoidal enclosure and an elliptical obstacle. The cavity lower wall is grooved and represents the heat source while the obstacle represents a stationary cold wall. On the other hand, the rest of the walls are considered adiabatic. The governing equations for this investigation are formulated, nondimensionalized, and then solved by Galerkin finite element approach. The numerical findings were examined across a wide range of Richardson number (0.1 ≤ Ri ≤ 10), Reynolds number (1 ≤ Re ≤ 125), Hartmann number (0 ≤ Ha ≤ 100), and volume fraction of nanofluid (0 ≤ φ ≤ 0.05). The current study's findings demonstrate that the flow strength increases inversely as the Reynolds number rises, which pushes the isotherms down to the lower part of the trapezoidal cavity. The Nu_avg rises as the Ri rise, the maximum Nu_avg = 10.345 at Ri = 10, Re = 50, ϕ = 0.05, and Ha = 0; however, it reduces with increasing Hartmann number. Also, it increase by increasing ϕ, at Ri = 10, the Nu_avg increased by 8.44% when the volume fraction of nanofluid increased from (ϕ = 0–0.05).     

A hybrid GA and PSO optimized approach for heart-disease prediction based on random forest

Multimedia Tools and Applications - Nowadays, heart diseases are significantly contributing to deaths all over the world. Thus, heart-disease prediction has garnered considerable attention in the...     

Excitation and spectral dependence of the rise and decay time responses of Eu2+- and Dy3+-doped strontium aluminates

Journal of Materials Science: Materials in Electronics - In this paper, we study the phosphorescence rise and decay time responses of Eu2+- and Dy3+-doped strontium aluminates prepared by different...     

Development of ensemble machine learning approaches for designing fiber-reinforced polymer composite strain prediction model

Engineering with Computers - Over the past few decades, it has been observed a remarkable progression in the development of computer aid models in the field of civil engineering. Machine learning...     

Vertex-Edge Degree Based Indices of Honey Comb Derived Network

Chemical graph theory is a branch of mathematics which combines graph theory and chemistry. Chemical reaction network theory is a territory of applied mathematics that endeavors to display the conduct of genuine compound frameworks. It pulled the research community due to its applications in theoretical and organic chemistry since 1960. Additionally, it also increases the interest the mathematicians due to the interesting mathematical structures and problems are involved. The structure of an interconnection network can be represented by a graph. In the network, vertices represent the processor nodes and edges represent the links between the processor nodes. Graph invariants play a vital feature in graph theory and distinguish the structural properties of graphs and networks. In this paper, we determined the newly introduced topological indices namely, first -degree Zagreb index, first -degree Zagreb index, second -degree Zagreb index, -degree Randic index, -degree atom-bond connectivity index, -degree geometric-arithmetic index, -degree harmonic index and -degree sum-connectivity index for honey comb derived network. In the analysis of the quantitative structure property relationships (QSPRs) and the quantitative structureactivity relationships (QSARs), graph invariants are important tools to approximate and predicate the properties of the biological and chemical compounds. Also, we give the numerical and graphical representation of our outcomes.     

Role of Rho GTPase Interacting Proteins in Subcellular Compartments of Podocytes

The first step of urine formation is the selective filtration of the plasma into the urinary space at the kidney structure called the glomerulus. The filtration barrier of the glomerulus allows blood cells and large proteins such as albumin to be retained while eliminating the waste products of the body. The filtration barrier consists of three layers: fenestrated endothelial cells, glomerular basement membrane, and podocytes. Podocytes are specialized epithelial cells featured by numerous, actin-based projections called foot processes. Proteins on the foot process membrane are connected to the well-organized intracellular actin network. The Rho family of small GTPases (Rho GTPases) act as intracellular molecular switches. They tightly regulate actin dynamics and subsequent diverse cellular functions such as adhesion, migration, and spreading. Previous studies using podocyte-specific transgenic or knockout animal models have established that Rho GTPases are crucial for the podocyte health and barrier function. However, little attention has been paid regarding subcellular locations where distinct Rho GTPases contribute to specific functions. In the current review, we discuss cellular events involving the prototypical Rho GTPases (RhoA, Rac1, and Cdc42) in podocytes, with particular focus on the subcellular compartments where the signaling events occur. We also provide our synthesized views of the current understanding and propose future research directions.     

Mangiferin Inhibits Apoptosis in Doxorubicin-Induced Vascular Endothelial Cells via the Nrf2 Signaling Pathway

Doxorubicin increases endothelial permeability, hence increasing cardiomyocytes’ exposure to doxorubicin (DOX) and exposing myocytes to more immediate damage. Reactive oxygen species are major effector molecules of doxorubicin’s activity. Mangiferin (MGN) is a xanthone derivative that consists of C-glucosylxanthone with additional antioxidant properties. This particular study assessed the effects of MGN on DOX-induced cytotoxicity in human umbilical vein endothelial cells’ (HUVECs’) signaling networks. Mechanistically, MGN dramatically elevated Nrf2 expression at both the messenger RNA and protein levels through the upregulation of the PI3K/AKT pathway, leading to an increase in Nrf2-downstream genes. Cell apoptosis was assessed with a caspase-3 activity assay, transferase-mediated dUTP-fluorescein nick end labeling (TUNEL) staining was performed to assess DNA fragmentation, and protein expression was determined by Western blot analysis. DOX markedly increased the generation of reactive oxygen species, PARP, caspase-3, and TUNEL-positive cell numbers, but reduced the expression of Bcl-2 and antioxidants’ intracellular concentrations. These were effectively antagonized with MGN (20 μM), which led to HUVECs being protected against DOX-induced apoptosis, partly through the PI3K/AKT-mediated NRF2/HO-1 signaling pathway, which could theoretically protect the vessels from severe DOX toxicity.