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排序方式: 共有1073条查询结果,搜索用时 46 毫秒
1.
Hiromasa Tanno Emi Kanno Suzuna Sato Yu Asao Mizuki Shimono Shiho Kurosaka Yukari Oikawa Shinyo Ishi Miki Shoji Ko Sato Jun Kasamatsu Tomomitsu Miyasaka Hideki Yamamoto Keiko Ishii Yoshimichi Imai Masahiro Tachi Kazuyoshi Kawakami 《International journal of molecular sciences》2021,22(8)
Chronic infections are considered one of the most severe problems in skin wounds, and bacteria are present in over 90% of chronic wounds. Pseudomonas aeruginosa is frequently isolated from chronic wounds and is thought to be a cause of delayed wound healing. Invariant natural killer T (iNKT) cells, unique lymphocytes with a potent regulatory ability in various inflammatory responses, accelerate the wound healing process. In the present study, we investigated the contribution of iNKT cells in the host defense against P. aeruginosa inoculation at the wound sites. We analyzed the re-epithelialization, bacterial load, accumulation of leukocytes, and production of cytokines and antimicrobial peptides. In iNKT cell–deficient (Jα18KO) mice, re-epithelialization was significantly decreased, and the number of live colonies was significantly increased, when compared with those in wild-type (WT) mice on day 7. IL-17A, and IL-22 production was significantly lower in Jα18KO mice than in WT mice on day 5. Furthermore, the administration of α-galactosylceramide (α-GalCer), a specific activator of iNKT cells, led to enhanced host protection, as shown by reduced bacterial load, and to increased production of IL-22, IL-23, and S100A9 compared that of with WT mice. These results suggest that iNKT cells promote P. aeruginosa clearance during skin wound healing. 相似文献
2.
Jun Ogata Kentaro Hirao Kenya Nishioka Arisa Hayashida Yuanzhe Li Hiroyo Yoshino Soichiro Shimizu Nobutaka Hattori Yuzuru Imai 《International journal of molecular sciences》2021,22(7)
Leucine-rich repeat kinase 2 (LRRK2) is a major causative gene of late-onset familial Parkinson’s disease (PD). The suppression of kinase activity is believed to confer neuroprotection, as most pathogenic variants of LRRK2 associated with PD exhibit increased kinase activity. We herein report a novel LRRK2 variant—p.G2294R—located in the WD40 domain, detected through targeted gene-panel screening in a patient with familial PD. The proband showed late-onset Parkinsonism with dysautonomia and a good response to levodopa, without cognitive decline or psychosis. Cultured cell experiments revealed that p.G2294R is highly destabilized at the protein level. The LRRK2 p.G2294R protein expression was upregulated in the patient’s peripheral blood lymphocytes. However, macrophages differentiated from the same peripheral blood showed decreased LRRK2 protein levels. Moreover, our experiment indicated reduced phagocytic activity in the pathogenic yeasts and α-synuclein fibrils. This PD case presents an example wherein the decrease in LRRK2 activity did not act in a neuroprotective manner. Further investigations are needed in order to elucidate the relationship between LRRK2 expression in the central nervous system and the pathogenesis caused by altered LRRK2 activity. 相似文献
3.
Ninrutsirikun Unhawa Imai Hideyuki Watanapa Bunthit Arpnikanondt Chonlameth 《Wireless Personal Communications》2020,115(4):2897-2916
Wireless Personal Communications - Studying computer programming requires not only an understanding of theories and concepts, but also coding pragmatism. Success in studying or conducting such a... 相似文献
4.
Shahira Said Aly Tsuyoshi Imai Mohamed Salah Hassouna Diem-Mai Kim Nguyen Takaya Higuchi Ariyo Kanno Koichi Yamamoto Rinji Akada Masahiko Sekine 《International Journal of Hydrogen Energy》2018,43(10):5300-5313
The ability of Clostridium butyricum RAK25832 to use casamino acids as a nitrogen source was investigated. Strain RAK25832 showed the capacity to utilize different types of carbon sources. With glucose as a carbon source (10 g/L), the preferred final concentration of casamino acids was 26.67 g/L, with a cumulative hydrogen production, production rate, and yield of 2505 mL H2/L, 160 mL/h, and 1.81 mol H2/mol glucose, respectively. Eighteen metal elements were screened to identify the most important metals for biohydrogen production, and four elements were optimized. The optimal medium composition was MgCl2·6H2O (0.1 g/L), K2HPO4·3H2O (6.67 g/L), NaHCO3 (2.6 g/L), and FeCl2·4H2O (0.002 g/L). Vitamin supplementation of the medium showed no significant effect on hydrogen production. Under the optimized conditions, cumulative hydrogen production reached 3074 mL H2/L. This is the first study to demonstrate the use of casamino acids as a nitrogen source by C. butyricum. 相似文献
5.
A Hydrogen Management Method in Residential Distributed Generation Systems with Photovoltaic Cells and Hydrogen‐Storage Type Fuel Cells 下载免费PDF全文
Ryosuke Takubo Akiko Takahashi Jun Imai Shigeyuki Funabiki 《Electrical Engineering in Japan》2015,193(3):8-16
Recently, renewable energy has been attracting attention as a result of global warming and the depletion of fossil fuels. Photovoltaic (PV) systems have spread rapidly around the world because they generate electric power quietly and can be installed in many places. The output power generated in a PV system fluctuates with changes in solar irradiance and panel temperature. The reverse flow of surplus power in output spikes may have a negative effect on electric power quality, such as on the frequency and voltage in a power system. A residential distributed generation (DG) system composed of a fuel cell (FC) unit, an electrolyzer (EL) unit, and a PV system has been proposed in order to resolve these problems. In order to operate this system without interruption, the hydrogen storage volume must be managed. This paper proposes a novel hydrogen management method for a residential DG system with PV cells and hydrogen‐storage type FCs. The hydrogen storage volume is maintained at the preset frequency by operating the FC unit and the EL unit. Models of the PV, FC, and EL were constructed for a simulation. In the simulation, we showed that the proposed management method is viable for a residential DG system with PV cells and hydrogen‐storage FCs. 相似文献
6.
Kenji Imai Koji Takai Tatsunori Hanai Makoto Shiraki Yusuke Suzuki Hideki Hayashi Takafumi Naiki Youichi Nishigaki Eiichi Tomita Masahito Shimizu Hisataka Moriwaki 《International journal of molecular sciences》2014,15(7):11294-11306
Obesity-related metabolic abnormalities, including adipokine imbalance and chronic inflammation, are involved in liver carcinogenesis. Chemerin, a novel adipokine, plays a critical role in adipogenesis, energy metabolism, and inflammation. We evaluated the impact of serum chemerin levels on liver functional reserves in hepatocellular carcinoma (HCC) patients and on the recurrence and prognosis of HCC. This study included 44 patients with any stage of HCC who underwent curative treatment at Gifu Municipal Hospital (Gifu, Japan) between 2006 and 2007. Recurrence-free survival and overall survival were estimated using the Kaplan-Meier method. Serum albumin levels (Pearson’s correlation coefficient; r = 0.3110, p = 0.0399), platelet counts (r = 0.4159, p = 0.0050), and prothrombin times (r = 0.3775, p = 0.0115) were significantly correlated with serum chemerin levels in patients with HCC, and they were inversely correlated with Child-Pugh scores (r = −0.3732, p = 0.0126), serum alanine aminotransferase levels (r = −0.3864, p = 0.0105), and total bilirubin levels (r = −0.4023, p = 0.0068). Among these variables, a multiple comparison test identified that platelet counts and total bilirubin levels were associated with serum chemerin levels (p < 0.0083). No significant correlation was found between serum chemerin levels and recurrence-free survival (p = 0.3691) or overall survival (p = 0.7916). In HCC patients, serum chemerin concentrations were correlated with liver functional reserves and platelet counts, but not with recurrence or prognosis. 相似文献
7.
Optimal Digital Controller Design for a Servo Motor Taking Account of Intersample Behavior 下载免费PDF全文
A continuous‐time plant with a discretized continuous‐time controller does not yield stability if the sampling rate is lower than some certain level. Thus far, high‐performance electronic control has made use of expensive hardware needed to implement discretized continuous‐time controllers; low‐cost hardware generally does not have a sufficiently high sampling rate. This technical note presents results comparing performance indexes with and without intersample behavior, and provides some answers to the question of how a low‐specification device can control a plant effectively. We consider a machine simulating wafer handling robots, which is an electromechanical system driven by a direct drive motor, at a semiconductor factory. We illustrate the controller design for the robot with and without intersample behavior, and present simulations and experimental results using these controllers. Taking intersample behavior into account proves to be effective in improving control performance and makes it possible to choose a relatively long sampling period. Controller design in terms of the performance index with intersample behavior makes it possible to deal with situations in which a sufficiently short sampling period may not be employed, and freedom of controller design may be widened, especially regarding the choice of the sampling period. 相似文献
8.
Thermoelectric materials have received much attention recently from the viewpoint of global environmental issues and effective
utilization of energy resources. Especially those effective at relatively low temperature, such as below 100°C, which are
usually abandoned without use, have become noteworthy recently. From this point of view, organic thermoelectric materials
are most attractive, because they could be prepared at low cost and applied in various locations due to their flexibility.
We have investigated the thermoelectric properties of organic conducting polymers such as polyaniline, polypyrrole, and polyphenylenevinylene,
and succeeded in increasing the thermoelectric performance by selecting dopants, stretching conducting films, etc. Recently
we have focused on new systems of organic–inorganic hybrid thermoelectric materials. Herein we present the preparation of
a novel system of hybrids of polyaniline and bismuth(III) telluride nanoparticles, starting from bismuth(III) chloride and
tetrachlorotellurium by using polyvinylpyrrolidone as a protecting reagent, as well as their thermoelectric properties. The
hybrids prepared by this particular method showed much higher thermoelectric performance than the starting organic conducting
polymer. 相似文献
9.
Hanane Fathi SeongHan Shin Kazukuni Kobara Hideki Imai 《Wireless Personal Communications》2010,54(1):225-236
To avoid the risk of long-term storage of secrets on a portable device, an online credential system supports the roaming user
in retrieving securely at various locations his private key and other material to generate anonymous signatures. The protocol
proposed here allows a roaming mobile user to access anonymously services such as whistle blowing and net-counselling. Our
approach: (1) allows a mobile user, remembering a short password, to anonymously and securely retrieve the credentials necessary
for his anonymous communication without assuming a pre-established anonymous channel to the credential server or establishing
an anonymous channel using the time-consuming existing rerouting techniques; (2) provides authenticated anonymous access to
privacy-related services without rerouting the packets; (3) helps combatting the abuse of anonymity for performing illegal
activities (e.g. redistribution of copy-righted contents, illegal drug trading and so on). 相似文献
10.
Kazuhiko Suzuki S. Seto A. Iwata M. Bingo T. Sawada K. Imai 《Journal of Electronic Materials》2000,29(6):704-707
The electron drift mobility of undoped Cd0.9Zn0.1Te grown by high-pressure Bridgman method is measured by a time-of-flight technique. The sample shows a room temperature mobility
and mobility lifetime product of 950 cm2/Vs and 1.6 × 10−4cm2/V, respectively. The mobility increases monotonically with decreasing temperature to 3000 cm2/Vs at 100 K. The dominant scattering mechanism for the electron transport is discussed by comparing with the theoretical
mobility obtained by iterative solution of the Boltzmann equation. 相似文献