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排序方式: 共有420条查询结果,搜索用时 31 毫秒
1.
Stefan Wolf Jeremy W. Deuel Maija Hollmn Gunther Felmerer Bong-Sung Kim Mauro Vasella Lisanne Grünherz Pietro Giovanoli Nicole Lindenblatt Epameinondas Gousopoulos 《International journal of molecular sciences》2021,22(7)
Lipedema is an adipose tissue disorder characterized by the disproportionate increase of subcutaneous fat tissue in the lower and/or upper extremities. The underlying pathomechanism remains unclear and no molecular biomarkers to distinguish the disease exist, leading to a large number of undiagnosed and misdiagnosed patients. To unravel the distinct molecular characteristic of lipedema we performed lipidomic analysis of the adipose tissue and serum of lipedema versus anatomically- and body mass index (BMI)-matched control patients. Both tissue groups showed no significant changes regarding lipid composition. As hyperplastic adipose tissue represents low-grade inflammation, the potential systemic effects on circulating cytokines were evaluated in lipedema and control patients using the Multiplex immunoassay system. Interestingly, increased systemic levels of interleukin 11 (p = 0.03), interleukin 28A (p = 0.04) and interleukin 29 (p = 0.04) were observed. As cytokines can influence metabolic activity, the metabolic phenotype of the stromal vascular fraction was examined, revealing significantly increased mitochondrial respiration in lipedema. In conclusion, despite sharing a comparable lipid profile with healthy adipose tissue, lipedema is characterized by a distinct systemic cytokine profile and metabolic activity of the stromal vascular fraction. 相似文献
2.
Ole Wiborg Martin O'Connell Richard Thiele Martin Wichert Gunther Kolb 《化学工程与技术》2015,38(8):1308-1314
Many critical issues need to be addressed when microstructured reactors are manufactured in large unit volumes. The most crucial of these are cost, ease of production, and reliability. The lack of breakthrough manufacturing technology to provide high‐efficiency, low‐cost, high‐precision plates is a hindrance to the early market implementation of systems requiring metallic microstructured plates. This contribution focuses on the development and optimization of a combined embossing and bending tool for the quick and continuous manufacture of easily machined plates. 相似文献
3.
Athanassios Ziogas Christian Hofmann Sebastian Baranyai Patrick Löb Gunther Kolb 《化学,工程师,技术》2020,92(5):513-524
A novel flexible electrochemical microreactor has been developed. Flexibility is reached by a modular design, suitability for a broad process parameter range including high pressure operation, and accessibility of production scale. Selected reactor aspects have been validated by applying the reactor to three different electrosyntheses: synthesis of tailor-made mixtures of paraffins by Kolbe electrolysis, cation flow method, and synthesis of peroxodicarbonate. High conversion rates, yields, selectivities, and Faraday efficiency levels have been observed, showing precise process control. 相似文献
4.
Leiber Daria Eickholt David Vuong Anh-Tu Reinhart Gunther 《Journal of Intelligent Manufacturing》2022,33(2):537-554
Journal of Intelligent Manufacturing - This article presents a novel approach for the automated 3D-layout planning of multi-station assembly lines. The planning method is based on a comprehensive... 相似文献
5.
Abstract. This article analyses participation in the annual European congresses of the Regional Science Association (ERSA) from 1998 through 2003. We formulate goals that the ERSA conferences should aim at and based on these aims we formulate hypotheses about conference participation. In the empirical part we test hypotheses with regard to the spatial distribution of the participants over countries, the distribution of the frequency of attendance among the participants, and the presence of distance decay in participation. All hypotheses are confirmed. We also pay attention to the relation between the frequency of attendance and distance. In the conclusions we derive implications for future conferences. 相似文献
6.
Martin Oberringer Erhan Akman Juseok Lee Wolfgang Metzger Cagri Kaan Akkan Elif Kacar Arif Demir Hashim Abdul-Khaliq Norbert Pütz Gunther Wennemuth Tim Pohlemann Michael Veith Cenk Aktas 《Materials science & engineering. C, Materials for biological applications》2013,33(2):901-908
In-stent restenosis is a common complication after stent surgery which leads to a dangerous wall narrowing of a blood vessel. Laser assisted patterning is one of the effective methods to modify the stent surface to control cell–surface interactions which play a major role in the restenosis. In this current study, 316LS stainless steel substrates are structured by focusing a femtosecond laser beam down to a spot size of 50 μm. By altering the laser induced spot density three distinct surfaces (low density (LD), medium density (MD) and high density (HD)) were prepared. While such surfaces are composed of primary microstructures, due to fast melting and re-solidification by ultra-short laser pulses, nanofeatures are also observed as secondary structures. Following a detailed surface characterization (chemical and physical properties of the surface), we used a well-established co-culture assay of human microvascular endothelial cells and human fibroblasts to check the cell compatibility of the prepared surfaces. The surfaces were analyzed in terms of cell adherence, proliferation, cell morphology and the differentiation of the fibroblast into the myofibroblast, which is a process indicating a general fibrotic shift within a certain tissue. It is observed that myofibroblast proliferation decreases significantly on laser treated samples in comparison to non-treated ones. On the other hand endothelial cell proliferation is not affected by the surface topography which is composed of micro- and nanostructures. Such surfaces may be used to modify stent surfaces for prevention or at least reduction of restenosis. 相似文献
7.
Gunther Helms 《Magma (New York, N.Y.)》2016,29(2):111-124
Segmentation of human brain using structural MRI is a key step of processing in imaging neuroscience. The methods have undergone a rapid development in the past two decades and are now widely available. This non-technical review aims at providing an overview and basic understanding of the most common software. Starting with the basis of structural MRI contrast in brain and imaging protocols, the concepts of voxel-based and surface-based segmentation are discussed. Special emphasis is given to the typical contrast features and morphological constraints of cortical and sub-cortical grey matter. In addition to the use for voxel-based morphometry, basic applications in quantitative MRI, cortical thickness estimations, and atrophy measurements as well as assignment of cortical regions and deep brain nuclei are briefly discussed. Finally, some fields for clinical applications are given. 相似文献
8.
Siegrid De Baere Thomas De Mil Gunther Antonissen Mathias Devreese Siska Croubels 《Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment》2018,35(9):1728-1738
Mycotoxin binders are feed additives which are mixed in the feed to adsorb mycotoxins and thereby reducing their toxic effects on animals. Interactions with orally administered veterinary medicinal products, such as antimicrobials or coccidiostats, have been reported previously. This paper describes an in vitro model to screen the interaction between mycotoxin binders and veterinary drugs with respect to the non-specific binding of drugs. It is designed as a static setup using a single concentration of drug and binder in a feed-containing or a feed-plus-mycotoxin-containing matrix, buffered at different pH values. The model was applied to two frequently used antimicrobials in veterinary medicine, doxycycline (DOX) and tylosin (TYL), one major mycotoxin, aflatoxin B1 (AFB1), and four mycotoxin binders. Proportions of feed, DOX or TYL, AFB1, and binder are equivalent to the in vivo situation for broiler chickens, while pH and volume of the buffer are representative of the gastrointestinal tract of chickens. A substantial binding of DOX (~ 88%) and TYL (~ 66%) to the feed-matrix was observed. For the mycotoxin binders, similar results were obtained for DOX and TYL; more specifically up to an inclusion rate of 20 g binder/kg feed, no significant binding was demonstrated, determined as the free concentration of DOX and TYL. A single exception was noticed for TYL and one specific bentonite-based mycotoxin binder, for which no significant interaction could be demonstrated up to 10 g binder/kg but there was an effect at 20 g/kg. In all cases, there was no competition between the tested drugs DOX or TYL and the mycotoxin AFB1 for binding to the bentonite-based mycotoxin binder. 相似文献
9.
Sets of multiple scalar fields can be used to model many types of variation in data, such as uncertainty in measurements and simulations or time‐dependent behavior of scalar quantities. Many structural properties of such fields can be explained by dependencies between different points in the scalar field. Although these dependencies can be of arbitrary complexity, correlation, i.e., the linear dependency, already provides significant structural information. Existing methods for correlation analysis are usually limited to positive correlation, handle only local dependencies, or use combinatorial approximations to this continuous problem. We present a new approach for computing and visualizing correlated regions in sets of 2‐dimensional scalar fields. This paper describes the following three main contributions: (i) An algorithm for hierarchical correlation clustering resulting in a dendrogram, (ii) a generalization of topological landscapes for dendrogram visualization, and (iii) a new method for incorporating negative correlation values in the clustering and visualization. All steps are designed to preserve the special properties of correlation coefficients. The results are visualized in two linked views, one showing the cluster hierarchy as 2D landscape and the other providing a spatial context in the scalar field's domain. Different coloring and texturing schemes coupled with interactive selection support an exploratory data analysis. 相似文献
10.
Tommy Lorenz Igor A. Baburin Jan-Ole Joswig Gotthard Seifert 《Israel journal of chemistry》2017,57(6):553-559
The present paper compares and discusses two selected misfit (layer) compounds exemplarily, namely SnS-SnS2 and LaS-TaS2. We have employed a density-functional theory-based approach to calculate structural, energetic, and electronic properties of these structures. We have put emphasis on the difference between single layers, combined double-layer systems and periodically stacked bulk structures. Especially the varying magnitudes of charge transfer between the sublayers were studied. We demonstrate how the chemical constitution of the sublayers affects the interlayer interactions: these may be a weak non-bonding van-der-Waals dominated interlayer interaction as in SnS-SnS2 and many other layered structures or a strong interaction related to a remarkable charge transfer between the layers as in LaS-TaS2. 相似文献