Effects of microstructure on fracture strength and conductivity of sintered NMC333

Sintering of LiNi_0.33Mn_0.33Co_0.33O₂ cathode material was investigated for potential application in all-electric aerospace propulsion systems utilizing new architectural concepts. All-solid-state batteries, while inherently safe, may not reach the high energy density required for next generation propulsion systems. To meet this performance requirement, multifunctionality of sintered active material may achieve systems level weight savings through simultaneous load bearing and electrochemical energy storage performance. The effects of sintering conditions on structural stability, chemistry, densification, grain size, fracture strength and electrical conductivity were quantified for the active cathode material. X-ray diffraction and inductively coupled plasma results indicated the structure and stoichiometry were maintained across the range of processing conditions to facilitate intercalation. Densification was achieved by sintering at 1050°C in ambient atmosphere, but grain coarsening was observed for higher temperatures and longer hold times. Mechanical strength was improved with reduction in porosity, but excessive grain growth decreased strength, providing a maximum of 50 MPa for samples sintered at 1050°C for 10 hours. Electrical conductivity initially improved with densification, but significantly diminished as the microstructure coarsened. The optimal sintering condition of 1050°C maximized mechanical fracture strength and electrical conductivity, with shorter sintering times preferred.     

Ambient fine particulate air pollution triggers ST-elevation myocardial infarction, but not non-ST elevation myocardial infarction: a case-crossover study

Background

We and others have shown that increases in particulate air pollutant (PM) concentrations in the previous hours and days have been associated with increased risks of myocardial infarction, but little is known about the relationships between air pollution and specific subsets of myocardial infarction, such as ST-elevation myocardial infarction (STEMI) and non ST-elevation myocardial infarction (NSTEMI).

Methods

Using data from acute coronary syndrome patients with STEMI (n?=?338) and NSTEMI (n?=?339) and case-crossover methods, we estimated the risk of STEMI and NSTEMI associated with increased ambient fine particle (<2.5 um) concentrations, ultrafine particle (10-100 nm) number concentrations, and accumulation mode particle (100-500 nm) number concentrations in the previous few hours and days.

Results

We found a significant 18% increase in the risk of STEMI associated with each 7.1 μg/m³ increase in PM_2.5 concentration in the previous hour prior to acute coronary syndrome onset, with smaller, non-significantly increased risks associated with increased fine particle concentrations in the previous 3, 12, and 24 hours. We found no pattern with NSTEMI. Estimates of the risk of STEMI associated with interquartile range increases in ultrafine particle and accumulation mode particle number concentrations in the previous 1 to 96 hours were all greater than 1.0, but not statistically significant. Patients with pre-existing hypertension had a significantly greater risk of STEMI associated with increased fine particle concentration in the previous hour than patients without hypertension.

Conclusions

Increased fine particle concentrations in the hour prior to acute coronary syndrome onset were associated with an increased risk of STEMI, but not NSTEMI. Patients with pre-existing hypertension and other cardiovascular disease appeared particularly susceptible. Further investigation into mechanisms by which PM can preferentially trigger STEMI over NSTEMI within this rapid time scale is needed.     

Binding Mode and Structure–Activity Relationships around Direct Inhibitors of the Nrf2–Keap1 Complex

An X‐ray crystal structure of Kelch‐like ECH‐associated protein (Keap1) co‐crystallised with (1S,2R)‐2‐[(1S)‐1‐[(1,3‐dioxo‐2,3‐dihydro‐1H‐isoindol‐2‐yl)methyl]‐1,2,3,4‐tetrahydroisoquinolin‐2‐carbonyl]cyclohexane‐1‐carboxylic acid (compound (S,R,S)‐ 1 a ) was obtained. This X‐ray crystal structure provides breakthrough experimental evidence for the true binding mode of the hit compound (S,R,S)‐ 1 a , as the ligand orientation was found to differ from that of the initial docking model, which was available at the start of the project. Crystallographic elucidation of this binding mode helped to focus and drive the drug design process more effectively and efficiently.     

Enclosure Smoke Filling and Management with Mechanical Ventilation

Enclosure smoke filling and management are addressed from the standpoint of the volumetric flow rates commonly used for mechanical ventilation system design. In this context, fire-induced gas expansion is treated as a volumetric source term. A two-layer analysis developed previously for enclosure smoke filling without mechanical ventilation is extended to consider the impact of mechanical ventilation on smoke layer descent rates and conditions within the smoke layer. A spreadsheet-based model of enclosure smoke filling developed in conjunction with the previous unventilated analysis is also extended to consider both mechanical extraction and injection systems. Some implications of mechanical ventilation on the development and descent of a smoke layer in an enclosure fire are discussed.     

The extinguishment of fires using low flow water hose streams—part II

Fire extinguishment tests were conducted in a simulated shipboard space. Portable extinguishers, a low flow water hose reel system, and 3.8 cm diameter water hand lines were used to extinguish the fires. Various protective ensembles were used by the fire fighters, ranging from minimum protection to full protection. Personnel with both a limited and high degree of fire fighting experience were used. Response time was influenced by visibility and the fire fighters' knowledge of the compartment. The low flow water hose reel system was found to be an effective and efficient quick response fire fighting tool. Efficiency, in terms of total water used, was better with the hose reel system compared to the larger, higher flow water hand lines.     

A computational and experimental study of ultra fine water mist as a total flooding agent

Computational fluid dynamics (CFD) calculations were carried out to design total flooding fire tests in a 28 m³ compartment for an ultra fine water mist (<10 μm). The exit momentum of the mist produced by a proprietary ultrasonic generator technology was extremely low with a mist discharge velocity below 1 m/s. The mist was discharged with multiple floor outlets equally spaced around the centrally located 120 kW pool-like gas fire. The transport of mist and its interaction with the fire was simulated by Fluent, a commercial CFD model. Lagrangian Discrete Phase Model (DPM) was used for droplets. Simulation predicted extinguishment within 10 s with a mist delivery rate of 1 l/min. However, in total flooding fire tests conducted, extinction times were more than 5 min. Additional computations approximating the ultra fine mist (UFM) as a dense gas agreed well with the observed transport timescales of minutes indicating that UFM behaves like a gas. Further, the mist–fire interaction needs a multi-phase Euler–Euler approach with a droplet vaporization model.