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1.
Broggi Andrea Tangstad Merete Ringdalen Eli 《Metallurgical and Materials Transactions B》2019,50(6):2667-2680
Metallurgical and Materials Transactions B - The reaction between SiO(g) and CO(g) is a relevant intermediate reaction in the silicon production process. One of the products generated from this gas... 相似文献
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Cheraghi Alireza Yoozbashizadeh Hossein Ringdalen Eli Safarian Jafar 《Metallurgical and Materials Transactions B》2019,50(4):1566-1580
Metallurgical and Materials Transactions B - The calcination and the reduction behaviors of a low-grade manganese ore by methane was studied at 973 K to 1273 K by several techniques. The onset... 相似文献
3.
The strength reliability of randomly heterogeneous beams is studied. The beams are considered as brittle, and failure by the weakest link criterion is assumed. The structure is statically indeterminate, thus the stress field is a function of the random morphology. The probabilistic beam strength is a coupled functional of morphology and stresses. Correlation between local strength and local modulus is also considered, and its effect on reliability is investigated. Heterogeneity is confined to the longitudinal direction only. An improved analytical solution is found by a new, optimized functional perturbation method (FPM). The improvement is achieved by two operations: generalizing the previously used FPM to account for multifunctional dependency, and choosing the perturbation to be around the proper homogeneous case for each type of morphology. It is shown that the improvement of the optimized method for reliability analysis is significant, and depends on the type of local strength-modulus statistical correlation. In addition, analytical results for very large and very small correlation lengths are obtained, and their validity range is examined by numerical solutions. 相似文献
4.
Culture-dependent and -independent methods were used to investigate the small eukaryote composition of raw and finished waters in the Norwegian cities of Oslo, Tromsø, Fredrikstad and Oppegård. Probes with general applicability to the 18S rRNA genes of the small eukaryote consortium were used for PCR-denaturing gradient gel electrophoresis (DGGE), and in the generation of clone libraries using the TOPO™ cloning and sequencing system. The chosen probes invariably gave a single band in agarose gel electrophoresis, indicating amplification of an area of similar size. DGGE and cloning analyses resolved the bands into components representing many unique amplicons. Diversity and composition in the collection were studied by DNA-sequencing, and visual examination of DGGE patterns. The cloning approach enabled the putative identification of a total of approximately 100 unique small eukaryotes. The major fraction of these represented ciliated and flagellated protozoal species. This was in keeping with the findings from protozoal cultivation. DNA from a number of multicellular eukaryotes was also detected. Amoebal and fungal DNA was rarely found. The latter may indicate a low incidence or a bias in the analysis technique. The population of small eukaryotes appears typical for pristine waters and no primary pathogens were detected by culture-independent techniques. However, the potentially pathogenic protozoa Acanthamoeba castellanii was grown on one occasion from Oslo’s drinking water.DGGE allowed the identification of fewer amplicons (by excision and sequencing of bands) than by the cloning-transformation approach. The DGGE analysis revealed clear similarities between the compositions of the raw and treated waters, indicating that cells or DNA in the raw water pass through the treatment trains. Protozoal culture and heterotrophic plate count analysis consistently revealed viable cells in both raw and treated waters in Oslo. This indicates that a fraction of the clone library represents eukaryotic species surviving the treatment trains. The analyses here presented represent the first published study of the general small eukaryotic fraction of the Capital’s drinking water, and those of three other Norwegian cities. We suggest that DGGE profiles may have a value in judging physical treatment efficacy (removal of cells), but that direct cloning and sequencing studies is more amenable for characterization of uncultured microbes. 相似文献
5.
Functional Chromatography Reveals Three Natural Products that Target the Same Protein with Distinct Mechanisms of Action 下载免费PDF全文
Dr. Min Jin Kang Dr. Tongde Wu Dr. E. M. Kithsiri Wijeratne Eric C. Lau Damian J. Mason Celestina Mesa Joseph Tillotson Prof. Dr. Donna D. Zhang Prof. Dr. A. A. Leslie Gunatilaka Dr. James J. La Clair Prof. Dr. Eli Chapman 《Chembiochem : a European journal of chemical biology》2014,15(14):2125-2131
Access to lead compounds with defined molecular targets continues to be a barrier to the translation of natural product resources. As a solution, we developed a system that uses discrete, recombinant proteins as the vehicles for natural product isolation. Here, we describe the use of this functional chromatographic method to identify natural products that bind to the AAA+ chaperone, p97, a promising cancer target. Application of this method to a panel of fungal and plant extracts identified rheoemodin, 1‐hydroxydehydroherbarin, and phomapyrrolidone A as distinct p97 modulators. Excitingly, each of these molecules displayed a unique mechanism of p97 modulation. This discovery provides strong support for the application of functional chromatography to the discovery of protein modulators that would likely escape traditional high‐throughput or phenotypic screening platforms. 相似文献
6.
Asllan Hajderi Eli Vyshka 《机械工程与自动化:英文版》2014,(10):799-803
In this study, it shows how the main indicators of torsional vibrations of the crankshaft change when its materials change. In the study, the crankshaft of diesel engine with four cylinders in line was taken, in which the material is changing from steel to cast iron, due to the technological possibilities of production. For study of torsional vibration of crankshaft system, the construction of equivalent reduced scheme is carried. Reduced inertia moments of discs are determined for each crank of crankshaft, by receiving the impact of piston group and rod mass. Reduced rigidities of crank are determined by experimental method. The results show that the rigidity of crank for the same crankshaft varies up to 6%, while the change between crankshafts goes up 10%. At the end, frequency and vibration forms are calculated using Tole-Holxer method. From calculations, it results that the frequencies are 19% smaller, while the vibration forms varies slightly. In this case, the change of the materials leads to the first frequency in the area of engine rotations and it can worsen the level of torsional vibration, therefore, it should check the resonance areas and vibration amplitude. 相似文献
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Eli Vandersluis Comondore Ravindran 《Transactions of the Indian Institute of Metals》2018,71(5):1231-1236
The design of improved casting systems requires accurate modeling of metal cooling processes. This can only be accomplished after determining the interfacial heat transfer coefficient (IHTC) between a solidifying casting and its mould. In the current work, a simple and robust inverse heat conduction technique was applied for the estimation of the effective IHTC between an aluminum alloy casting and a steel permanent mould during solidification. The solidification of the alloy at varying mould preheating temperatures was monitored using a thermocouple, and the experimental cooling curves were compared with curves simulated by casting solidification modeling software. The IHTC value applied to the software was varied until its output converged with the experimental data, leading to an estimation of 6000 W/m2K for this system. This technique is useful as a preliminary tool in materials modeling, and it will promote the development of improved casting processes without the need for excessive experimentation. 相似文献
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