Decentralized Hierarchical Coded Caching Over Heterogeneous Wireless Networks with Multi-level Popularity Content

Wireless Personal Communications - Decentralized hierarchical coded caching is studied with two layers of caches which users receive their demands through intermediate helpers from a main server....     

Fabrication and characterization of highly efficient three component CuBTC/graphene oxide/PSF membrane for gas separation application

Metal organic frameworks (MOFs) with marvelous properties have aroused enormous attention for different application especially gas adsorption and separation. In this regard, fabrication of MOF hybrids with carbon based materials is new strategy to upgrade MOF performance. In this study CuBTC (Copper benzene-1,3,5-tricarboxylic acid)/graphene oxide (GO) composite was synthesized and characterized by BET, SEM, TGA, XRD and FT-IR techniques. Then CuBTC and CuBTC/GO composite were incorporated into polysulfone (PSF) polymer to construct mixed matrix membranes (MMMs). The obtained membranes were characterized by SEM, TGA, XRD and tensile tests and their gas permeability was measured. The results were compared to those of CuBTC/PSF MMMs. It was revealed that CuBTC/GO composite as filler showed superior performance relative to CuBTC. For instance, 15 wt% loading of CuBTC/GO in PSF represented outstanding gas separation behavior while the same loading of CuBTC in PSF deteriorated performance of MMM. Well particle dispersion and favorable polymer-filler interaction were responsible for such observed difference. A high H₂/CH₄ and H₂/N₂ selectivity of 80.03 and 70.46 were recorded for CuBTC/GO in PSF (15 wt%) compared to 44.56 and 40.92 for CuBTC in PSF (15 wt%).     

Novel electrospun polymer electrolytes incorporated with Keggin‐type hetero polyoxometalate fillers as solvent‐free electrolytes for lithium ion batteries

In this study, solvent‐free nanofibrous electrolytes were fabricated through an electrospinning method. Polyethylene oxide (PEO), lithium perchlorate and ethylene carbonate were used as polymer matrix, salt and plasticizer respectively in the electrolyte structures. Keggin‐type hetero polyoxometalate (Cu‐POM@Ru‐rGO, Ni‐POM@Ru‐rGO and Co‐POM@Ru‐rGO (POM, polyoxometalate; rGO, reduced graphene oxide)) nanoparticles were synthesized and inserted into the PEO‐based nanofibrous electrolytes. TEM and SEM analyses were carried out for further evaluation of the synthesized filler structures and the electrospun nanofibre morphologies. The fractions of free ions and crystalline phases of the as‐spun electrolytes were estimated by obtaining Fourier transform infrared and XRD spectra, respectively. The results showed a significant improvement in the ionic conductivity of the nanofibrous electrolytes by increasing filler concentrations. The highest ionic conductivity of 0.28 mS cm^?1 was obtained by the introduction of 0.49 wt% Co‐POM@Ru‐rGO into the electrospun electrolyte at ambient temperature. Compared with solution‐cast polymeric electrolytes, the electrospun electrolytes present superior ionic conductivity. Moreover, the cycle stability of the as‐spun electrolytes was clearly improved by the addition of fillers. Furthermore, the mechanical strength was enhanced with the insertion of 0.07 wt% fillers to the electrospun electrolytes. The results implied that the prepared nanofibres are good candidates as solvent‐free electrolytes for lithium ion batteries. © 2020 Society of Chemical Industry     

Novel NGR anchored pullulan micelles for controlled and targeted delivery of doxorubicin to HeLa cancerous cells

Doxorubicin (DOX) is used to treat different kinds of cancers, including cervix carcinoma. However, it has various side effects such as cardiotoxicity. Nano-sized controlled releasing carriers such as polymeric micelles are of interesting approaches to overcome these side effects of doxorubicin in cancer chemotherapy. Regarding the up-regulation of CD13/APN receptors on the cervix carcinoma cells, which can bind to peptide sequences specially NGR (asparagine–glycine–arginine) with high affinity, peptide sequence (NGR) targeted micelles would lead to effective treatment of this carcinoma. In this study, the NGR peptide sequence was synthesized using the solution-phase strategy from asparagine, glycine, and arginine residues. The pullulan–retinoic acid conjugate and pullulan–retinoic acid–NGR conjugate were prepared by the amide and ester bond formation between the hydroxyl groups of pullulan and carboxylic acid groups of retinoic acid and peptide sequence. Pullulan–retinoic acid–NGR micelles were prepared by the direct dissolution method. The optimized micelles, according to their particle size (124.5 nm), zeta potential (? 3.65 mV), entrapment efficiency (85%), and release of DOX (70%, within 72 h) were assessed for their cytotoxicity on HeLa cells using MTT assay. NGR-targeted pullulan/retinoic acid micelles had higher cytotoxicity than the free DOX in cell culture studies on the HeLa cell line, and this can be a promising result in the treatment of cervix carcinoma.     

PEG-PLA-PCL based electrospun yarns with curcumin control release property as suture

This work presents an interesting method using an electrospinning process to fabricate suture yarns loaded with curcumin to achieve reasonable mechanical properties as well as tunable drug release behavior. Different structures including different yarn counts and twists as well as core-sheath structures were used to adjust drug release properties along with improving the yarn's mechanical properties. The core parts were made of polycaprolactone and the sheath parts were made of polyethylene glycol, polylactic acid, and polycaprolactone. Drugs can be incorporated in both parts based on the required condition and application. Electrospun yarns were compared using both structural properties and their drug release profiles as metrics. The results of comparing drug release profiles of six electrospun yarns with different yarn counts and twists showed that yarns with finer fiber diameters in the core part have more drug release as well as more initial release. Overall evaluations showed that core-sheath drugloaded yarn with appropriate physical and mechanical properties can be a useful material as a drug delivery system to the site of damaged tissue. It can also be concluded that the amount and duration of drug release can be controlled using the structural parameters of electrospun yarns as an engineering tool for designing suture yarns with required properties.     

Outlier accommodation in moving-horizon state estimation: A risk-averse performance-specified approach

This paper presents a novel state estimation approach for linear dynamic systems when measurements are corrupted by outliers. Since outliers can degrade the performance of state estimation, outlier accommodation is critical. The standard approach combines outlier detection utilizing Neyman-Pearson (NP) type tests with a Kalman filter (KF). This approach ignores all residuals greater than a designer-specified threshold. When measurements with outliers are used (ie, missed detections), both the state estimate and the error covariance matrix become corrupted. This corrupted state and covariance estimate are then the basis for all subsequent outlier decisions. When valid measurements are rejected (ie, false alarms), potentially using the corrupted state estimate and error covariance, measurement information is lost. Either using invalid information or discarding too much valid information can result in divergence of the KF. An alternative approach is moving-horizon (MH) state estimation, which maintains all recent measurement data within a moving window with a time horizon of length L. In MH approaches, the number of measurements available for state estimation is affected by both the number of measurements per time step and the number of time steps L over which measurements are retained. Risk-averse performance-specified (RAPS) state estimation works within an optimization setting to choose a set of measurements that achieves a performance specification with minimum risk of outlier inclusion. This paper derives and formulates the MH-RAPS solution for outlier accommodation. The paper also presents implementation results. The MH-RAPS application uses Global Navigation Satellite Systems measurements to estimate the state of a moving platform using a position, velocity, and acceleration model. In this application, MH-RAPS performance is compared with MH-NP state estimation.     

Synthesis of Janus/non-Janus hollow graphene oxide micro- and nanoparticles and the effects of their localization on the thermal conductivity of blend-based polymer composites

Journal of Materials Science - In this study, the effects of Janus, hydrophilic and hydrophobic hollow graphene oxide (HO) particles on the thermal conductivity of binary polymer blends were...     

Investigating the effect of custom‐made insoles and exercises on lower limb and back discomfort in assembly‐line workers in a rubber tire factory: A randomized controlled trial

Many occupations require standing for prolonged periods, which can be a major contributor to musculoskeletal problems and cause disturbances in different parts of the body, especially the lower back and lower extremities. The aim of this study was to investigate the effect of custom‐made insoles and exercise training on the lower limb and lower back discomfort in workers on a production line at a rubber tire factory. One hundred male workers (mean age 35.96 years, work experience of 10.62 years, standing time 6.58 hr) participated in this randomized controlled trial. The men were randomly assigned to one of four groups: (a) custom‐made insole plus lower limb exercises, (b) insoles only, (c) lower limb exercises only, and (d) no intervention. Discomfort level was recorded with a visual analog scale and a body map. The data were analyzed with analysis of covariance. The results showed a significant difference in discomfort levels between groups in the lower back (p = .001), thigh (p = .001), and knee (p = .001) areas. The combined insole and exercise group had less discomfort in the lower back, thigh, and knee. In the group that used the insole only without exercises, the discomfort level in the lower back area was reduced. The results indicate that the simultaneous use of insoles and exercises might be an effective intervention to reduce discomfort in the lower limbs and lower back in workers who remain standing for prolonged periods.     

Increasing Angiogenesis Factors in Hypoxic Diabetic Wound Conditions by siRNA Delivery: Additive Effect of LbL-Gold Nanocarriers and Desloratadine-Induced Lysosomal Escape

Impaired wound healing in people with diabetes has multifactorial causes, with insufficient neovascularization being one of the most important. Hypoxia-inducible factor-1 (HIF-1) plays a central role in the hypoxia-induced response by activating angiogenesis factors. As its activity is under precise regulatory control of prolyl-hydroxylase domain 2 (PHD-2), downregulation of PHD-2 by small interfering RNA (siRNA) could stabilize HIF-1α and, therefore, upregulate the expression of pro-angiogenic factors as well. Intracellular delivery of siRNA can be achieved with nanocarriers that must fulfill several requirements, including high stability, low toxicity, and high transfection efficiency. Here, we designed and compared the performance of layer-by-layer self-assembled siRNA-loaded gold nanoparticles with two different outer layers—Chitosan (AuNP@CS) and Poly L-arginine (AuNP@PLA). Although both formulations have exactly the same core, we find that a PLA outer layer improves the endosomal escape of siRNA, and therefore, transfection efficiency, after endocytic uptake in NIH-3T3 cells. Furthermore, we found that endosomal escape of AuNP@PLA could be improved further when cells were additionally treated with desloratadine, thus outperforming commercial reagents such as Lipofectamine^® and jetPRIME^®. AuNP@PLA in combination with desloratadine was proven to induce PHD-2 silencing in fibroblasts, allowing upregulation of pro-angiogenic pathways. This finding in an in vitro context constitutes a first step towards improving diabetic wound healing with siRNA therapy.