Paroxysmal atrial fibrillation

Paroxysmal atrial fibrillation is the most frequent of cardiac arrhythmias and its frequency increases with age. Its diagnosis is difficult since the symptoms are often absent or misleading. It is based on electrocardiogram performed during the attack, and this has been made easier by the Holter technique or by sequential recordings triggered by the patient himself. It is only in special cases, when percritical recordings could not be made that intracavitary electrophysiological study is used to obtain indirect arguments in favour of the diagnosis. All heart diseases can be attended by this cardiac rhythm disorder which usually marks an unfavourable turn in the course of the disease, with an increased risk of sudden death in the end. But in most cases the only disorder found is a common arterial hypertension. Atrial fibrillation carries a risk of peripheral, and in particular cerebral, embolism evaluated at 5% per annum. This risk is high in patients with cardiopathy, but it also exists even with a normal heart. The value of anticoagulants has been demonstrated by large controlled studies, but it is important to know that a very strong anticoagulant treatment is unnecessary to reduce the risk of embolism. Only antiarrhythmic agents can maintain the patients in sinus rhythm for as long as possible before the passage to permanent fibrillation. Although no beneficial effect on mortality has been proved, these drugs are indicated for patients who have very marked symptoms or a major cardiopathy.(ABSTRACT TRUNCATED AT 250 WORDS)     

A refined statistical approach to thermal fatigue life prediction

Finding new applications for ceramic materials requires a better knowledge of thermal fatigue behaviour. However, result-scattering inherent to thermal fatigue and duration of a thermal fatigue cycle lead to a lack of experimental results. For these reasons, we have developed a new approach that permits the determination of a relevant stress intensity factor exponent n with a minimum testing sample number. From knowledge of the distribution function of artificial cracks, the analytical formula of the failure probability F(N) can be completely determined. Thus, it is possible to calculate n from a correlation of F(N) with experimental results obtained for only one temperature difference. Correlations between theoretical curves F(N) and experimental results, conducted for two temperature differences, lead to the same value of n. This and the good agreement between the experimental points and the theoretical curves validate this new approach.     

Myocardial imaging with technetium-99m-tetrofosmin: comparison of one-day and two-day protocols

There is no evidence of myocardial redistribution after tetrofosmin injection, therefore, two separate injections are needed to differentiate scar from ischemia with this tracer. The injections can be given on the same day (one-day protocol) or on separate days (two-day protocol). As part of a Phase II clinical study, a one-day protocol was compared with a two-day protocol. METHODS: Fifty-five patients with suspected coronary artery disease were studied according to the following protocol: on the first day at rest, anterior, left lateral, left anterior oblique 40 degrees and 70 degrees images were acquired 30 min after injection of 8 mCi of tetrofosmin for 5 min each. Two days later, exercise and rest images were acquired on the same day. At peak exercise, 8 mCi of tetrofosmin were injected and 30 min later the same four standard planar images were recorded as on Day one. Four hours after the exercise injection, 24 mCi of tetrofosmin were injected at rest and imaging was repeated 30 min later. Qualitative comparisons between the one- and two-day protocols were performed in 50 patients in whom all data were available following blinded evaluation of images by three readers. RESULTS: All three readers reported identical results for the 26 patients. A difference in extent or location between the observers was found in seven patients, differences between normal and abnormal in eight patients, while discrepancies between ischemia and necrosis were noted in four patients. In five patients, an ischemic area was found according to the one-day protocol, but according to the data of the two-day protocol, this area was judged to be necrotic. One observer reported the opposite in one patient. These discrepancies between the reversibility of defects were restricted to the inferior wall. Comparison with 201Tl data showed no systematic pattern of variation. CONCLUSION: Tetrofosmin can be used in a one-day protocol. However, in planar imaging, the inferior wall should be reported with caution.     

DREAM: A Component Framework for Constructing Resource-Aware, Configurable Middleware

DREAM (dynamic reflective asynchronous middleware) is a software framework for building asynchronous middleware from components, which we can assemble statically or dynamically (at deployment time or at runtime). DREAM's component library and set of tools lets us build, configure, and deploy middleware that implements various asynchronous communication paradigms, including message-passing, event-reaction, and publish-subscribe. We show how to use our framework to dynamically control resource consumption and concurrency. The performance of dynamically configurable MOMs built with the DREAM framework compares favorably to monolithic, functionally equivalent middleware     

Control of structure and tack properties of acrylic pressure‐sensitive adhesives designed by a polymerization process

Free radical emulsion polymerization of methyl methacrylate (MMA) and 2‐ethylhexyl acrylate (EHA) results in the synthesis of pressure‐sensitive adhesives (PSAs) with good tack properties. Management of both the copolymer composition and the polymerization process allows one to control the behavior of the PSA. Semicontinuous (SC) processes create polymer particles whose instantaneous composition is close to that of the feed particle The SC Mixture process (continuous feeding with comonomer blends) affords nearly homogeneous latex particles and PSA films. The SC Gradient process (separate feedings at inversely varying rates) affords heterogeneous particles and films. The Batch process leads to somewhat heterogeneous films, but the hard (MMA‐rich) microdomains are made compatible with their soft (EHA‐rich) matrix because of the assumed formation of tapered‐type copolymers. Tack measurements indicate the importance of the particle and film structures. Too much hardness or softness leads to unacceptable lacks of adhesion and cohesion, respectively. Homogeneous structures prove adequate, but their tack properties collapse with rising temperature. Heterogeneous structures, with extensive phase segregation, prove unsatisfactory because they lack adhesion and cohesion. Finally, the association of well‐balanced composition and compatible heterogeneity is the criterion for suitable PSA behavior. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 89: 2749–2756, 2003     

PHP and SQL made simple

The book Build Your Own Database Driven Website Using PHP & MySQL by Kevin Yank provides a hands-on look at what's involved in building a database-driven Web site. The author does a good job of patiently teaching the reader how to install and configure PHP 5 and MySQL to organize dynamic Web pages and put together a viable content management system. At just over 350 pages, the book is rather small compared to a lot of others on the topic, but it contains all the essentials. The author employs excellent teaching techniques to set up the foundation stone by stone and then grouts everything solidly together later in the book. This book aims at intermediate and advanced Web designers looking to make the leap to server-side programming. The author assumes his readers are comfortable with simple HTML. He provides an excellent introduction to PHP and MySQL (including installation) and explains how to make them work together. The amount of material he covers guarantees that almost any reader will benefit.     

Synthesis of ditungsten carbide by controlled decomposition of Cp2W2(CO)4 (dmad) under a hydrogen atmosphere

Controlled decomposition studies of the bis(cyclopentadienyl)ditungsten(tetracarbonyl)-dimethylacetylenedicarboxylate (Cp2W2(CO)4(dmad)) under flowing hydrogen show that it totally decomposes at 600 °C for 2 h to give a pure bulk W2C as revealed by X-ray diffraction. Excess oxygen and carbon at the surface are detected by X-ray photoelectron spectroscopy. An in situ temperature-programmed X-ray diffraction experiment performed on Cp2W2(CO)4 (dmad) shows the detection temperature of W2C to be 600 °C, the sample being amorphous or microcrystalline below that temperature. Based on previous results obtained for the decomposition of Cp2Mo2(CO)4(dmad) on the one hand, and thermogravimetric and chromatographic analyses performed on Cp2W2(CO)4 (dmad), on the other, a decomposition scheme of the latter under hydrogen has been proposed. © 1998 Chapman & Hall     

Association of IgG1 Antibody Clearance with FcγRIIA Polymorphism and Platelet Count in Infliximab-Treated Patients

The FcγRIIA/CD32A is mainly expressed on platelets, myeloid and several endothelial cells. Its affinity is considered insufficient for allowing significant binding of monomeric IgG, while its H131R polymorphism (histidine > arginine at position 131) influences affinity for multimeric IgG2. Platelet FcγRIIA has been reported to contribute to IgG-containing immune-complexe clearance. Given our finding that platelet FcγRIIA actually binds monomeric IgG, we investigated the role of platelets and FcγRIIA in IgG antibody elimination. We used pharmacokinetics analysis of infliximab (IgG1) in individuals with controlled Crohn’s disease. The influence of platelet count and FcγRIIA polymorphism was quantified by multivariate linear modelling. The infliximab half-life increased with R allele number (13.2, 14.4 and 15.6 days for HH, HR and RR patients, respectively). It decreased with increasing platelet count in R carriers: from ≈20 days (RR) and ≈17 days (HR) at 150 × 10⁹/L, respectively, to ≈13 days (both HR and RR) at 350 × 10⁹/L. Moreover, a flow cytometry assay showed that infliximab and monomeric IgG1 bound efficiently to platelet FcγRIIA H and R allotypes, whereas panitumumab and IgG2 bound poorly to the latter. We propose that infliximab (and presumably any IgG1 antibody) elimination is partly due to an unappreciated mechanism dependent on binding to platelet FcγRIIA, which is probably tuned by its affinity for IgG2.