Health benefits of orally administered anti-IL-10 antibody in milk-fed dairy calves

The primary objective of this randomized controlled trial was to determine whether anti-IL-10 egg yolk antibodies fed upon arrival to a calf ranch would lower the prevalence of Cryptosporidium parvum shedding in naturally challenged preweaned dairy calves. The secondary objectives included measuring the effect of anti-IL-10 antibodies on calf health, performance, and shedding of less common diarrheal pathogens. A total of 133 calves, enrolled at 24 to 72 h of age, received a daily dose of 0.96 g of egg yolk powder with anti-IL-10 antibodies (MAB, n = 71) or without anti-IL-10 antibodies (MEP, n = 62) split between 2 feedings for the first 11 d on feed at a calf ranch. Daily health evaluations were completed for 15 d after arrival and on d 56. Digital weights were collected at enrollment and d 56, and hipometer weights were collected at enrollment and d 7 and 56. Packed cell volume and serum total protein concentration were measured at enrollment and on d 7 and 14. Fecal pH was measured at enrollment and on d 5 and 14, and fecal pathogen (C. parvum, coronavirus, rotavirus, and Salmonella spp.) shedding was assessed at d 5 and 14. Continuous outcomes were compared between groups using a Student's t-test or Wilcoxon rank sum test. Fecal pathogen shedding at d 14, respiratory disease at d 56, and antibiotic usage were compared using relative risk (RR) and chi-squared test. Fecal pH (median and interquartile range) on d 14 was 6.65 (6.39–6.99) and 6.52 (5.97–6.81) for MAB and MEP, respectively. On d 56, the risk of respiratory disease was lower for MAB compared with MEP (RR = 0.40; confidence interval = 0.16–0.99). The risk for antibiotic treatment was lower for MAB- compared with MEP-treated calves (RR = 0.38; confidence interval = 0.17–0.88). The risk of shedding rotavirus was higher in MAB (RR = 1.38; confidence interval = 1.10–1.81) calves. After multivariable analyses, hipometer weights (least squares means ± standard error) were 1.7 ± 0.8 kg greater on d 56 in MAB compared with MEP; however, ADG was 0.04 ± 0.02 kg/d lower in MAB calves. Total health score, diarrhea days, average respiratory score, packed cell volume, and serum total protein were not affected by feeding anti-IL-10 egg antibodies. In summary, feeding anti-IL-10 antibodies was associated with increased fecal pH, reduced risk of respiratory disease later in the preweaning period, and decreased antibiotic usage despite higher rotavirus infection. These findings might be associated with improved mucosal immunity, enhanced host defenses, or reduced susceptibility and warrant further investigation.     

Self Assembly–Assisted Additive Manufacturing: Direct Ink Write 3D Printing of Epoxy–Amine Thermosets

The use of self‐assembling, pre‐polymer materials in 3D printing is rare, due to difficulties of facilitating printing with low molecular weight species and preserving their reactivity and/or functions on the macroscale. Akin to 3D printing of small molecules, examples of extrusion‐based printing of pre‐polymer thermosets are uncommon, arising from their limited rheological tuneability and slow reactions kinetics. The direct ink write (DIW) 3D printing of a two‐part resin, Epon 828 and Jeffamine D230, using a self‐assembly approach is reported. Through the addition of self‐assembling, ureidopyrimidinone‐modified Jeffamine D230 and nanoclay filler, suitable viscoelastic properties are obtained, enabling 3D printing of the epoxy–amine pre‐polymer resin. A significant increase in viscosity is observed, with an infinite shear rate viscosity of approximately two orders of magnitude higher than control resins, in addition to, an increase in yield strength and thixotropic behavior. Printing of simple geometries is demonstrated with parts showing excellent interlayer adhesion, unachievable using control resins.     

Assessing robustness of factor ranking for supersaturated designs

Supersaturated designs can potentially be a beneficial tool for efficiently exploring a large number of factors with a moderately sized design. However, because more factors are being considered than there are runs, the stability of the identified factors depends heavily on effect sparsity and the lack of highly influential observations. A helpful tool for the analysis of supersaturated designs is least absolute shrinkage and selection operation (LASSO), which is useful when the effects of many explanatory variables are sparse in a high‐dimensional dataset. To understand the impact of individual observations on the selected factors, the LASSO influence plot was created. This paper describes an application of this plot and its variants that can be used to identify influential points, increase understanding of the impact of individual observations on model parameters, and the robustness of results in analyses with supersaturated designs. These graphical methods can serve as a complement to other regression diagnostics techniques in the LASSO regression setting.     

A critical evaluation of indentation crack lengths in air

An extensive overview is presented of Vickers indentation crack lengths in ceramics in air. Measurement of such crack lengths is one of the most common and powerful assessments of the fracture properties of ceramics and the overview provides a critical evaluation of observed behavior as functions of material type and indentation load, and an extensive basis for comparison of results from new materials and analyses. The overview considers single crystals, polycrystals, transforming materials, glasses, and multiphase materials, including cermets, glass-ceramics, and tooth enamel. The coverage extends over structural and electronic ceramics, including oxides, carbides, nitrides, and titanates. The data are presented in a single format for ease of interpretation in terms of idealized indentation fracture and for inter-material comparisons; most data are unique to this work, but the results of selected studies from the published literature are included. The overview considers the precision and accuracy of crack length measurements and demonstrates a simple quantitative evaluation and ranking scheme for ceramic fracture based on load-adjusted crack length and cracking susceptibility. Indentation hardness and cracking threshold are also determined and related to the susceptibility. Material toughness is related to cracking susceptibility by fracture mechanics analyses: typical crack length measurements in air are shown to provide estimates of inert toughness with a relative uncertainty of ±50%.     

Strength of brittle materials in moderately corrosive environments

The strengths of four brittle materials―cordierite glass ceramic, fused silica, silicon, and polycrystalline alumina were measured after exposure to weakly corrosive water and moderately corrosive buffered HF (BHF) solution. Exposure to water did not alter the strengths in subsequent inert strength tests and decreased the strengths in reactive strength tests. Exposure to BHF increased the strengths in both tests, but only after an incubation exposure time. Prior to the incubation time, the BHF had the same effect as water, suggesting that the bond rupture kinetics were unaffected. Examination of strength‐controlling indentation flaws after the incubation time showed clear corrosive effects on the flaw geometry indicative of reductions in the indentation residual stress fields. The implication is that moderately corrosive environments increase the strength or lifetime of a brittle component by reducing the crack driving force via flaw alteration and do not, as perhaps expected, decrease the strength or lifetime through enhanced chemical reactivity.     

XRF法快速测定铝土矿火车样

采用压样法，使用国产便携式Ｘ射线光分析仪快速测定铝土矿火车样中的铝、硅、磷、硫、钾、钙、铁、钛８个元素。文章对标样的采集、制样、仪器某些性能的改进，各种影响因素的校正（如基体效应、谱叠加干扰等）、数学模型的研究开发等作了简要说明，提出了解决问题的基本原则，在小型仪器上攻克了铝土矿火车样工业分析的难题。该技术具有准确、快速、成本低的优点。     

Landscape structure indices for assessing urban ecological networks

Analysis and planning of ecological networks is a relatively new phenomenon and is a response to fragmentation and deterioration of quality of natural systems. In urban areas, the problems of land use intransigence, political and jurisdictional issues create a difficult environment for implementing ecological networks. The specific questions addressed in this research program revolve around the viability of planning an ecological network in an urban landscape. The development and articulation of an ecological network plan was undertaken previously and in this paper, a series of assays of landscape structure are used to examine the viability of an ecological network in the Phoenix, Arizona urban area. Three principal analyses were utilized: (1) patch content analysis, (2) corridor content analysis, and (3) network structure analysis. Patch and corridor content analyses examined the internal characteristic and immediate context for each of the 89 ecological network elements. The network structure analysis incorporates a process for aggregating results of patch and corridor analyses and incorporates indicators that describe interrelationships between landscape elements. For each of these analyses the existing condition was compared to the optimal plan to demonstrate the level of change that can be expected. The results and conclusions of this research are that an ecological network plan provides modest but important improvement in ecological systems in the Phoenix urban area.