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1.
Magdy Germein Harb Mohamed E. Elshaer A. M. Saad Laila Ebrahim Shaker Soliman Moataz 《JOM Journal of the Minerals, Metals and Materials Society》2019,71(6):1944-1951
JOM - Nanofibers were prepared from a poly(acrylonitrile-co-vinyl acetate) [P(AN-co-VAC)]/polyvinylidene fluoride (PVDF) blend and used as a quasi-solid (QS) electrolyte for dye-sensitized solar... 相似文献
2.
Dr. Yahu A. Liu Dr. Qihui Jin Qiang Ding Dr. Xueshi Hao Tingting Mo Shanshan Yan Dr. Yefen Zou Dr. Zhihong Huang Xiaoyue Zhang Wenqi Gao Dr. Tom Y.-H. Wu Chun Li Dr. Badry Bursalaya Dr. Michael Di Donato Dr. You-Qing Zhang Lisa Deaton Dr. Weijun Shen Dr. Brandon Taylor Anwesh Kamireddy Dr. George Harb Dr. Jing Li Dr. Yong Jia Dr. Andrew M. Schumacher Dr. Bryan Laffitte Dr. Richard Glynne Dr. Shifeng Pan Dr. Peter McNamara Dr. Valentina Molteni Dr. Jon Loren 《ChemMedChem》2020,15(16):1562-1570
Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell mass are less developed. Promoting β-cell proliferation with low-molecular-weight inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) offers the potential to treat diabetes with oral therapies by restoring β-cell mass, insulin content and glycemic control. GNF4877, a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) was previously reported to induce primary human β-cell proliferation in vitro and in vivo. Herein, we describe the lead optimization that lead to the identification of GNF4877 from an aminopyrazine hit identified in a phenotypic high-throughput screening campaign measuring β-cell proliferation. 相似文献
3.
In this effort, a two-dimensional photonic crystal ring resonator (2DPCRR) is simulated. This device is developed for temperature detection in harsh enviro 相似文献
4.
Kumar A. Madhan Ehsan Muhammad Ali Suleiman Rami K. Hakeem Abbas Saeed 《Metallurgical and Materials Transactions A》2020,51(8):4301-4312
Metallurgical and Materials Transactions A - The surface of implant materials is one of the most significant factors for controlling the interaction between biomaterials and bone tissues. Hence,... 相似文献
5.
Mowakeaa Rami Boukouvalas Zois Long Qunfang Adali Tülay 《Multidimensional Systems and Signal Processing》2020,31(2):725-744
Multidimensional Systems and Signal Processing - Examples of complex-valued random phenomena in science and engineering are abound, and joint blind source separation (JBSS) provides an effective... 相似文献
6.
European Journal of Wood and Wood Products - Surface tension of solid wood surfaces affects the wettability and thus the adhesion of various adhesives and wood coatings. By measuring the contact... 相似文献
7.
Harb Rita Rivera-Tinoco Rodrigo Zeghondy Barbar Bouallou Chakib 《Clean Technologies and Environmental Policy》2022,24(1):379-392
Clean Technologies and Environmental Policy - Biomass gasification is the thermo-chemical conversion of biomass into producer gas. The latter can be then integrated in a combined heat and power... 相似文献
8.
9.
Networks and Spatial Economics - Advanced attackers use online social networks in order to extract useful information about targeted organizations, including the names of the organization’s... 相似文献
10.
Hashem O. Alsaab Alanoud S. Al-Hibs Rami Alzhrani Khawlah K. Alrabighi Aljawharah Alqathama Akram Alwithenani Atiah H. Almalki Yusuf S. Althobaiti 《International journal of molecular sciences》2021,22(4)
Angiogenesis is one of the hallmarks of cancer. Several studies have shown that vascular endothelium growth factor (VEGF) plays a leading role in angiogenesis progression. Antiangiogenic medication has gained substantial recognition and is commonly administered in many forms of human cancer, leading to a rising interest in cancer therapy. However, this treatment method can lead to a deteriorating outcome of resistance, invasion, distant metastasis, and overall survival relative to its cytotoxicity. Furthermore, there are significant obstacles in tracking the efficacy of antiangiogenic treatments by incorporating positive biomarkers into clinical settings. These shortcomings underline the essential need to identify additional angiogenic inhibitors that target numerous angiogenic factors or to develop a new method for drug delivery of current inhibitors. The great benefits of nanoparticles are their potential, based on their specific properties, to be effective mechanisms that concentrate on the biological system and control various important functions. Among various therapeutic approaches, nanotechnology has emerged as a new strategy for treating different cancer types. This article attempts to demonstrate the huge potential for targeted nanoparticles and their molecular imaging applications. Notably, several nanoparticles have been developed and engineered to demonstrate antiangiogenic features. This nanomedicine could effectively treat a number of cancers using antiangiogenic therapies as an alternative approach. We also discuss the latest antiangiogenic and nanotherapeutic strategies and highlight tumor vessels and their microenvironments. 相似文献