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1.
Ergonomics assessment in the automotive industry has, to date, focused mainly on physical ergonomics, for example, manual handling and posture. However, workload and, in particular, metabolic and cognitive workload, contributes to worker efficiency but has not received sufficient attention to yield practical guidance for industry. Successful workload assessment requires in-depth understanding of the context in which it will be conducted and of the various assessment techniques which will be applied, with consideration given to factors such as feasibility, resources, and skill of the assessor. These requirements are met with challenges within large and complex organizations and are often dealt with in a piecemeal and isolated matter (i.e., reactive workload assessment). The present paper explores these challenges within the automotive manufacturing industry and aims to develop a decision matrix to guide effective selection of workload assessment techniques focused on metabolic and cognitive demands. It also presents the requirements for time, equipment, and knowledge to implement these techniques as part of a participatory ergonomics approach. Early findings suggest that most assessment techniques reviewed require further development, for example, to establish the acceptance criteria for the specific workload scenario. However, five methods (Garg, Borg RPE, IPAQ, SWAT, and NASA-TLX) are ready to use in certain applications. Ultimately, the findings suggest that it is possible to implement a participatory workload evaluation program within large and complex manufacturing plants.  相似文献   
2.
The Cooperative Institute for Great Lakes Research (CIGLR) in collaboration with the Great Lakes Observing System and National Oceanic and Atmospheric Administration, Great Lakes Environmental Research Laboratory (NOAA GLERL) deployed an autonomous underwater glider in southern Lake Michigan several times per year between 2012 and 2019 to collect offshore (>30 m depth) limnological measurements, including temperature, photosynthetically active radiation (beginning during 2015), and chlorophyll fluorescence. From these data, we calculated mixed layer depth, several measures of light penetration (diffuse attenuation coefficient, first optical depth, euphotic zone depth), and depth of the subsurface chlorophyll maxima. During summer, mean offshore mixed layer depth was typically 10–15 m, Kd for PAR was 0.1–0.17 m?1, first optical depth was 6–9 m, euphotic zone depth was 35–40 m, and depth of subsurface chlorophyll maxima was 30–35 m. We also observed substantial spatial and temporal variation in these values across the basin and within and among seasons. Glider-based observations provide a wider horizontal and vertical perspective than other methods (e.g., ship- and satellite-based observations, buoys, and fixed moorings), and are therefore a valuable, complementary tool for Great Lakes limnology. The set of observations reported here provide seasonal and basin-scale information that may help to identify anomalies useful for future glider-assisted investigation into the role of biophysical processes in Great Lakes limnology and ecology.  相似文献   
3.
It is common in the literature on the reliability and maintenance of repairable systems to model the repair times as instantaneous. However, this is an unreasonable assumption for some complex systems, especially those requiring a high level of reliability, and such systems may spend a significant proportion of their lifetimes under maintenance and repair. We model the ageing of such a system with alternating stochastic processes. Operational times are generated at random and may have an increasing failure rate. Repair times are generated from a random process where the repair time is related to the hazard rate at failure. This yields lengthened repair times at late stages in a system subject to an increasing failure hazard rate but also accommodates long repair times at young ages in systems with a bathtub-shaped hazard rate function. We derive analytic results for a set of special cases of the model, show how simulation and inference can be carried out, and apply our method to real data from a large car manufacturer.  相似文献   
4.
We used the molecular modeling program Rosetta to identify clusters of amino acid substitutions in antibody fragments (scFvs and scAbs) that improve global protein stability and resistance to thermal deactivation. Using this methodology, we increased the melting temperature (Tm) and resistance to heat treatment of an antibody fragment that binds to the Clostridium botulinum hemagglutinin protein (anti-HA33). Two designed antibody fragment variants with two amino acid replacement clusters, designed to stabilize local regions, were shown to have both higher Tm compared to the parental scFv and importantly to retain full antigen binding activity after 2 hr of incubation at 70°C. The crystal structure of one thermostabilized scFv variants was solved at 1.6 Å and shown to be in close agreement with the RosettaAntibody model prediction.  相似文献   
5.
Ventilation system analysis for underground mines has remained mostly unchanged since the Atkinson method was made popular by Mc Elroy in 1935. Data available to ventilation technicians and engineers is typically limited to the quantity of air moving through any given heading. Because computer-aided modelling, simulation, and ventilation system design tools have improved, it is now important to ensure that developed models have the most accurate information possible. This paper presents a new technique for estimating underground drift friction factors that works by processing 3 D point cloud data obtained by using a mobile Li DAR. Presented are field results that compare the proposed approach with previously published algorithms, as well as with manually acquired measurements.  相似文献   
6.
7.

Background

A new tool, the SIMARD-MD, has been proposed to help physicians identify cognitively impaired drivers who may be unfit to drive, but little empirical evidence is available to justify its use. We analyzed data from a cohort of older Canadian drivers who had undergone cognitive testing to: (1) correlate the SIMARD-MD with other tools that measure cognition (e.g., trail-making test), (2) identify how many drivers, using published cut-offs on the SIMARD-MD, would be recommended to lose their license, or be considered fit to drive, or be required to undergo further driving assessment, and (3) determine if the SIMARD-MD is biased by level of education as many cognitive tools are.

Methods

Cross-sectional data from 841 drivers aged 70 and over from seven Canadian sites who are enrolled in a 5-year cohort study were used for the analyses. Scores on the SIMARD-MD were correlated with scores on the other cognitive measures. The recommendations that would be made based on the SIMARD-MD scores were based on published cut-off values suggested by the authors of the tool. The impact of education status was examined using linear regression controlling for age.

Results

Correlations between the SIMARD-MD and other cognitive measures ranged from .15 to .86. Using published cut-off scores, 21 participants (2.5%) would have been recommended to relinquish their licenses, 428 (50.9%) would have been deemed fit to drive, and 392 (46.6%) would have been required to undergo further testing. We found a difference of 8.19 points (95% CI = 4.99, 11.40, p < .001) in favor of drivers with post-secondary education versus those without, representing over 11% of the mean score.

Discussion

The SIMARD-MD is unlikely to be valuable to clinicians because it lacks sufficient precision to provide clear recommendations about fitness-to-drive. Recommendations based solely on the SIMARD-MD may place many seniors at risk of losing their transportation mobility or incurring unnecessary stress and costs to prove they are safe to drive. Furthermore, the education bias may create an unwanted structural inequity. Hence, adoption of the SIMARD-MD as a tool to determine fitness-to-drive appears premature.  相似文献   
8.
On a Windows platform it is possible to inject a DLL into a running process creating a new thread of execution within an authorized process. Security tools monitoring or examining DLLs loaded into the memory space of a given process rely on policies to determine the validity of the library. Two approaches to the policy specification include “all or nothing” and “per executable” rules also referred to as a run-time security policy. Developing the run-time policy requires the running of every executable for a period of time to train the system. An alternative to the training method of the run-time approach is to determine ahead of time which DLL should be loaded before execution. A tool called LibMon was developed to monitor loading of libraries by running applications. A heuristic search algorithm was created based on the analysis of the data collected with LibMon.  相似文献   
9.
Graduated driver licensing (GDL) programs are specialized licensing systems for beginner drivers adopted in all U.S. states, Australia, Canada, and New Zealand. GDL programs reduce novice drivers’ exposure to high-risk driving situations while they gain driving experience. Several studies document the success of GDL programs overall in reducing young teen crash rates. However, little is known about which specific components of these programs (e.g., nighttime driving restrictions) and which calibrations of these components (e.g., 10 PM, 11 PM, 12 AM, or 1 AM), are associated with the largest crash reductions. The goal of this study was to identify the GDL component calibrations associated with the largest reductions in fatal crash involvements for 16–17-year-olds. Driver fatal crash involvements for all U.S. states from 1986 to 2007 were analyzed using Poisson regression models to estimate the association of various GDL component calibrations with 16- and 17-year-old driver fatal crash incidence, after adjusting for potential confounders. We found clear evidence that (a) a minimum learner permit holding period of 9–12 months and (b) a passenger restriction allowing only one teen passenger for 6 months or longer are the calibrations for the learner permit holding period and passenger restriction components associated with the largest reductions in 16–17-year-old driver fatal crash involvements. Additionally, the data suggest that (a) disallowing learner driving until age 16, (b) disallowing intermediate licensure until age 16½ to 17, and (c) a nighttime driving restriction starting at 10 PM or earlier are the calibrations for these components associated with the largest reductions in 16-year-old driver fatal crashes. There was no clear evidence to support particular calibrations for supervised driving hours or unrestricted license ages.  相似文献   
10.
The R6 Procedure and the ‘Assessment procedure for the high temperature response of structures’, R5, are well known and continue to be developed by Nuclear Electric Ltd in the UK. This paper looks at the software that has been developed to help undertake the calculations required by these assessment procedures. R-CODE version 3.00 computerises creep crack growth and incorporates simplified creep-fatigue crack growth calculations. The program may also be used to perform assessments according to PD6539 and PD6493 or BS7910. Full allowance can be made for incubation and redistribution periods. Continuum damage may be evaluated in terms of life fraction or ductility exhaustion methods. The program covers all the Categories, Options and Failure Assessment Diagrams of R6, for defining stability under short-term loadings when used for low temperature assessments.  相似文献   
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