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2.
K Nakata H Gotoh J Watanabe T Uetake I Komuro K Yuasa S Watanabe R Ieki H Sakamaki H Akiyama S Kudoh M Naitoh H Satoh K Shimada 《Canadian Metallurgical Quarterly》1999,93(2):667-673
After allogeneic bone marrow transplantation (allo-BMT), recipient alveolar macrophages (AM) are gradually replaced by AM of the donor origin. An influx of mononuclear phagocytes of donor origin to the lung is responsible for the repopulation, but the detailed kinetics remain unclear. We therefore studied 24 BMT recipients who underwent bronchoalveolar lavage (BAL) from 24 to 83 days after BMT. AM cell number, size, morphology, proliferating ability, and genotype of AM were measured. Before day 50, the number and size of AM in BAL fluid were similar to those of normal nonsmokers. However, after day 50, the mean number of AM increased threefold and the mean cell size decreased due to the increase of small AM. These small cells are presumably of donor origin based on DNA fingerprinting analysis and based on fluorescence in situ hybridization for the Y chromosome in a sex-mismatched case. Immunohistochemistry and cell cycle analysis demonstrated that the increase in AM number coincided with a remarkable increase of AM expressing proliferating cell nuclear antigen, suggesting that small AM are proliferating. This is the first report representing that augmented proliferation of donor AM in situ may contribute to the reconstitution of AM population after BMT. 相似文献
3.
KyoungHou Kim Ryo Aida YoungAh Kang Yutaka Ohkoshi Yasuo Gotoh Masanobu Nagura Hiroshi Urakawa 《Polymer》2009,50(19):4429-4431
The structure development in the continuous laser-heated drawing process of poly(ethylene 2,6-naphthalene dicarboxylate) (PEN) fiber was analyzed by in-situ X-ray diffraction measurement. Because of the rapid and uniform laser heating, and the resultant steady-state nature of the necking-drawing, the structure development after the on-set of necking could be measured in the time resolution of several hundred microseconds. We found for the first time the temporal appearance of meridional (001′) diffraction at several milliseconds after the on-set of necking indicating that the mesophase structure similar to the one reported for poly(ethylene terephthalate) was also formed in the initial stage of fiber structure development of PEN. The d-spacing of the (001′) diffraction 1.230 ± 0.003 nm was shorter than the c-axis lengths of both α and β crystals. 相似文献
4.
Naohiro Gotoh Shino Miyake Hiroko Takei Kumi Sasaki Saori Okuda Michitaka Ishinaga Shun Wada 《Food Analytical Methods》2011,4(4):525-530
We developed a simple method for quantification of the peroxide value (PV) in colored lipids on the basis of the reaction
between triphenylphosphine (TPP) and oxidized oil to afford triphenylphosphineoxide (TPPO). Diphenylphosphineoxide (DPPO)
was employed as internal standard. The formed TPPO was analyzed by high-pressure liquid chromatography–UV spectroscopy with
absorption at 260 nm. The conditions that gave the highest correlative calibration curve between the peak area on the chromatogram
and peroxide value were identified: the optimum TPP–oxidized oil mix ratio, reaction temperature, and reaction time were found
to be 2:1, 40 °C, and 30 min, respectively. Linear calibration curves, passing through the origin, were obtained for PV versus
TPPO and TPPO versus DPPO. The quantification limit for this method was 2.01 pmol hydroperoxyl group, which corresponds to
a PV value of 0.2 meq/kg in a 10-mg oil sample. This method was used to measure the PV in colored fats and oils or lipids
extracted from dark meat and processed food containing a coloring agent. Though the official method could not measure the
PVs in the colored lipids, the method proposed here, which uses an inexpensive chemical reagent and machine, could. The developed
method could play an important role for food quality control. 相似文献
5.
The reason for the increase of R21 which is defined by the intensity ratio of the doubly charged ions to the singly charged ions, was studied. Based on the conventional field evaporation theory, an increase in the electric field and/or the source temperature is considered to be attributable. We took the fact that R21 turned to decrease at the higher current regime into consideration and examined whether the change of R21 due to change in the field or temperature would finally meet the criterion for the decrease of R21. It was concluded that an increase of the source temperature may be a possible reason for the increase of R21. 相似文献
6.
Kuniaki Gotoh Takashi Kawazu Mikio Yoshida Jun Oshitani 《Advanced Powder Technology》2010,21(1):34-40
A method for dispersing dry particles in a liquid is described. The method involves coating large carrier particles with fine particles. When two types of particles having different sizes are mixed in dry conditions, the particles adhere to one another, and the large particles become coated with small particles. When the large core particles are coated with a mono-layer of small particles, further agglomeration is inhibited. Because the single small particles generated by the disruption adhere to the core particles, we presumed that, if the small particles that are adhered to large particles could be separated from the large particles by a sonication in a liquid, the dry fine particles could be dispersed in a liquid.The dispersion experiments conducted using spherical silica particles having a count median diameter Dp50 of 74 nm as small particles and spherical glass beads as large particles. In this situation, the large particles carry the small particles from a dry condition into a liquid. We refer to the large particles as carrier particles. The experiments revealed that the proposed dispersion procedure results in a superior product, compared to sonication only. The effect of carrier size on dispersion performance is also investigated. The findings indicate and an optimum carrier size exists. Observations of the carrier particle surfaces after dry mixing indicate that the optimum condition is the condition at which a mono-layer of Silica particles is formed. 相似文献
7.
Akira Kaieda Dr. Masashi Takahashi Hiromi Fukuda Dr. Rei Okamoto Dr. Shinji Morimoto Masayuki Gotoh Takahiro Miyazaki Yuri Hori Satoko Unno Dr. Tomohiro Kawamoto Dr. Toshimasa Tanaka Dr. Sachiko Itono Terufumi Takagi Dr. Hiroshi Sugimoto Dr. Kengo Okada Dr. Weston Lane Dr. Bi-Ching Sang Dr. Kumar Saikatendu Dr. Shinichiro Matsunaga Dr. Seiji Miwatashi 《ChemMedChem》2019,14(24):2093-2101
We identified novel potent inhibitors of p38 mitogen-activated protein (MAP) kinase using a structure-based design strategy, beginning with lead compound, 3-(butan-2-yl)-6-(2,4-difluoroanilino)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one ( 1 ). To enhance the inhibitory activity of 1 against production of tumor necrosis factor-α (TNF-α) in human whole blood (hWB) cell assays, we designed and synthesized hybrid compounds in which the imidazo[4,5-b]pyridin-2-one core was successfully linked with the p-methylbenzamide fragment. Among the compounds evaluated, 3-(3-tert-butyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-6-yl)-4-methyl-N-(1-methyl-1H-pyrazol-3-yl)benzamide ( 25 ) exhibited potent p38 inhibition, superior suppression of TNF-α production in hWB cells, and also significant in vivo efficacy in a rat model of collagen-induced arthritis (CIA). In this paper, we report the discovery of potent, selective, and orally bioavailable imidazo[4,5-b]pyridin-2-one-based p38 MAP kinase inhibitors. 相似文献
8.
Lei Che Masahide Gotoh Yoshiaki Horimoto Yukio Hirose Lin Yang 《Journal of Materials Engineering and Performance》2008,17(3):445-453
This article deals with the characterization of the mechanical behaviors of spheroidized carbon steels, which contain ferrite
and spheroidal cementite. The aim of the study is to identify the deformation behaviors of cementite particles by x-ray diffraction
and to correlate them to the residual stress state evolution. The stress state evolutions for both phases during an in situ 4-point bending test and after a uniaxial tensile test that have been well followed by x-ray diffraction. After each tensile
loading, optical observation is made to correlate the determined residual stress state with the microstructure. The coupling
of techniques helps us to characterize the deformation evolution of spheroidal cementite in the carbon steel: at the initial
state, the cementite shows the same elastic behavior as the ferrite; at the next state, the ferrite begins to deform plastically
but the cementite deforms elastically; then, plastic relaxation occurs in the ferrite while the cementite still deforms elastically
until finally breaking. 相似文献
9.
A seven-day immersion test using several solutions was conducted on stainless steel, Co-based alloy, and Ni–Ti alloy, which are used for stents and stent grafts. The quantitative data on the release of each metal ion and the correlation between metal ion release rate and pH were obtained. The quantities of Fe and Ni released from stainless steel gradually decreased with increasing solution pH (pH 2–7.5). For Co–Cr–Mo–Ni–Fe alloy, the quantity of Cr released steadily increased as pH decreased (pH ≤ 6) and reached nearly zero at pHs higher than 6 (pH 6–7.5). Co release was slightly affected by a variation in pH. The quantities of Ni and Ti released from Ni–Ti alloy markedly increased with decreasing pH (pH ≤ 4) and they leveled off from pH 4 (pH 4–7.5). Although the rapid increases were observed at approximately pH 2, the quantities were even higher than that of Co released from the Co–Cr–Mo and Co–Cr–Mo–Ni–Fe alloys. For further investigation of the rapid increase in the quantities of metals released at pH 2, an anodic polarization test was employed to study the passive and transpassive behaviours of Ni–Ti alloy. The critical current density for the passivation of Ni–Ti alloy markedly increased as pH decreased (pH ≤ 4) and was low (1.4 μA/cm2) at pH higher than 4 (pH 4–7.5). The potential at a current density of 10 μA/cm2, by contrast, markedly rose with decreasing pH (pH ≤ 2), and was 1.2 V from pH 2 (pH 2–7.5). 相似文献
10.
Md. Majibur Rahman Khan Yasuo Gotoh Hideaki Morikawa Mikihiko Miura 《Journal of Materials Science》2009,44(16):4235-4240
In order to investigate the graphitization behavior of Bombyx mori silk fibroin (SF) fibers, structural inspection of carbonized SF fibers treated with iodine vapor was studied at different
temperatures, from 800 to 1400 °C. Wide angle X-ray diffraction measurement suggested that both untreated and iodinated SF
fibers exhibited amorphous structure carbonized to 1200 °C. After carbonization at 1400 °C for 12 h, a graphite-like structure
was obtained. Raman spectroscopy and transmission electron microscopic observation showed that the graphite layers of SF fibers
became more ordered after iodine treatment. The carbon yield obtained at higher temperature (1400 °C) after iodine treatment
was higher, ca. 28 wt%, than that of untreated SF. 相似文献