Fe-based bulk metallic glasses (BMGs) with high boron content have potential application as a coating material used in the framework for storing spent nuclear fuels to support their safe long-term disposal. The high glass forming ability (GFA) and large supercooled liquid region are therefore required for such Fe-based BMGs in either the glassy powder fabrication or the subsequent coating spraying. In order to meet these requirements, the influence of Nb content on the GFA of Fe57Cr10Zr8B18Mo7−xNbx (x=1–5, at.%) alloys was investigated, as Nb has positive roles in GFA and thermal stability of BMGs. The results indicate that a fully amorphous phase in the as-cast samples with 3 mm in diameter is obtained for both the Fe57Cr10Zr8B18Mo5Nb2 and Fe57Cr10Zr8B18Mo4Nb3 alloys. The corresponding supercooled liquid regions of the two BMGs are 78 K and 71 K, respectively. The mechanism for improving their GFA was analyzed based on the principle of metal solidification, the parameters for glass formation and thermal properties of the alloys. The compression strength and Vicker’s hardness of the two BMGs are 1,950 MPa and 1,310 HV, 2,062 MPa and 1,180 HV, respectively. The developed BMGs with high B content, good GFA, and very high hardness can be used as coating materials to the framework for spent nuclear fuels.
药物相互作用改变了剂量效应关系,可能会降低疗效或增加毒性,是临床应用中合并用药治疗时重要的考虑因素。预测具有临床意义的药物相互作用是药物研发过程中获益风险评估的重要环节。本文概述了药物研发过程中药物相互作用研究的目的和意义,体内和体外研究的主要内容;梳理分析了2020年国家药品监督管理局(National Medical Products Administration, NMPA)和美国食品药品监督管理局(Food and Drug Administration, FDA)批准上市的新药药物相互作用研究情况,旨在为我国药物研发过程中药物相互作用研究及其监管审评提供参考。 相似文献
Up to now, it is a major challenge to protect leading edge of the blades from solid particle erosion. Herein, we propose a structure optimization strategy to fabricate non-woven (NW) enhanced thermoplastic polyurethane nanocomposite films (thermoplastic polyurethane [TPU] - NW@G/Cx) with “sandwich - like” structure by hot pressing technology. TPU NW/graphene nanoplates/carbon nanotube (NW@G/Cx) interlayer film were first fabricated by spraying method. Then the interlayer film was laminated between TPU films to fabricate nanocomposite films. Such prepared TPU - NW@G/Cx film shows excellent solid particle erosion resistance and high-tensile strength. For example, the “steel-and-mortar” structure of NW fabric in TPU film results in high-tensile strength of 45 MPa and storage modulus of 21.2 MPa for TPU - NW@G/C1.0, increasing by 25% and 171% compared with original TPU film (35 MPa, 8 MPa), respectively. In addition, compared with pure TPU film, the “sandwich - like” structure endows TPU - NW@G/C1.2 with excellent solid particle erosion resistance and the thermal conductivity (0.251 W/m·K). These superior properties extends application of the TPU - NW@G/Cx film on wind turbine blades. 相似文献