Analysis of Combined Systems of Two Endoreversible Engines

A single endoreversible engine can operate as a cooler, a true heat engine, a heat pump, or a refrigerator. We investigate how many different modes of operation a combined system of two endoreversible engines may display. Special attention is paid to the independent combined system which neither consumes nor supplies power.     

Fast dynamic casting

We describe a scheme for implementing dynamic casts suitable for systems where the performance and predictability of performance is essential. A dynamic cast from a base class to a derived class in an object‐oriented language can be performed quickly by having the linker assign an integer type ID to each class. A simple integer arithmetic operation verifies whether the cast is legal at run time. The type ID scheme presented uses the modulo function to check that one class derives from another. A 64‐bit type ID is sufficient to handle class hierarchies of large size at least nine levels of derivation deep. We also discuss the pointer adjustments required for a C++ dynamic_cast. All examples will be drawn from the C++ language. Copyright © 2005 John Wiley & Sons, Ltd.     

Prediction of fire classification for wood based products. A multivariate statistical approach based on the cone calorimeter

Wood has long traditions as a building material, and is often used in construction elements, and as interior and exterior surfaces in the Nordic countries. In most applications, there are reaction to fire requirements to products used as surfaces, e.g. in escape routes and larger public spaces. Most wood products will therefore have to be treated with fire retardant (FR) agents to fulfil the strict requirements to properties connected to heat release and flame spread. Unfortunately, FR agents usually also increase the smoke production, as they cause a more incomplete combustion of the wood. The wood product manufacturers seek to find the optimal amount of FR additives where both heat release and smoke production in the classifying test are within the requirements given in the building regulations. This paper describes models for prediction of the European reaction to fire classes of wood products. The models are based on multivariate statistical analysis, and use test results from the cone calorimeter test as input. The presented models are, with very good precision, able to predict which Euroclass and additional smoke class a wood based product would obtain if it were to be tested in the single burning item test. Copyright © 2006 John Wiley & Sons, Ltd.     

Left and Right Pathlengths in Random Binary Trees

We study the difference between the left and right total pathlengths in a random binary tree. The results include exact and asymptotic formulas for moments and an asymptotic distribution that can be expressed in terms of either the Brownian snake or ISE. The proofs are based on computing expectations for a subcritical binary Galton-Watson tree, and studying asymptotics as the Galton-Watson process approaches a critical one.     

Determination of somatostatin receptor subtype 2 in carcinoid tumors by immunohistochemical investigation with somatostatin receptor subtype 2 antibodies

We have shown previously that expression of mRNA for somatostatin receptor subtype 2 (sst2) detected by in situ hybridization correlates to therapeutic outcome in patients with carcinoid tumors treated with somatostatin analogues. However, in situ hybridization is laborious and not practical in clinical routine work. We have, therefore, developed polyclonal antibodies directed against sst2 that may be used for immunohistochemistry on tissue specimens. The staining is specific and is highly correlated to expression of mRNA for sst2 (P < 0.01) as well as to tracer uptake at somatostatin receptor scintigraphy (P < 0.01). There is also a good correlation to the therapeutic response in carcinoid patients treated with somatostatin analogues (P < 0.05). Of 35 patients with carcinoid tumors included in this investigation, 25 stained positive with the antibodies. Twenty-two of these were investigated by somatostatin receptor scintigraphy and showed tracer uptake in metastases. An additional two patients that did not stain with the antibodies showed pathological uptake of the tracer in metastases, which might indicate binding to somatostatin receptor subtype 5. None of the 10 patients without positive immunostaining responded to somatostatin analogue treatment, whereas patients with a positive stain had a biochemical response or remained stable during treatment. Thus, these antibodies may be used to determine the presence of sst2 in carcinoid tumors and to select patients suitable for somatostatin analogue treatment. The method is easily applicable in clinical practice.     

A new block-based method for copy move forgery detection under image geometric transforms

Copy move forgery detection (CMFD) is one of the most active subtopic in forgery scheme. The methods of CMFD are divided into to block-based method and keypoint-based method in general. Compared with keypoint-based method, block-based method can detect undetectable detail without morphology segmentation. But many block-based methods detect the plain copy-move forgeries only. They have been incompetent to detect the post-processing operations such as various geometrical distortions, and then fail to detect the forgery regions accurately. Therefore, this paper presents an improved block-based efficient method for CMFD. Firstly, after pre-processing, an auxiliary overlapped circular block is presented to divide the forged image into overlapped circular blocks. The local and inner image feature is extracted by the Discrete Radial Harmonic Fourier Moments (DRHFMs) with the overlapped circular block from the suspicious image. Then, the similar feature vectors of blocks are searched by 2 Nearest Neighbors (2NN) test. Euclidean distance and correlation coefficient is employed to filter these features and then remove the false matches. Morphologic operation is employed to delete the isolated pixels. A series of experiments are done to analyze the performance for CMFD. Experimental results show that the new DRHFMs can obtain outstanding performance even under image geometrical distortions.     

A common network flow formulation for several civil engineering problems

This paper discusses a common network flow problem that arises in four areas of civil engineering. The problem is one of identifying arc flows that simultaneously satisfy the circuit and node law constraints for a given network. Applications and computational procedures in the areas of elastic structural analysis, hydraulic network analysis, traffic equilibrium and construction task scheduling are described. The interpretation of decision variables and mathematical functions will vary depending on the application, but the general priblem formulation and solution technique for each application remains essentially unchanged. Analogies between the different applications may enhance the conceptual understanding and intuition of engineers working in each area.     

Kinetic modeling of hemicellulose hydrolysis in the presence of homogeneous and heterogeneous catalysts

Kinetic models were developed for the hydrolysis of O‐acetyl‐galactoglucomannan (GGM), a hemicellulose appearing in coniferous trees. Homogeneous and heterogeneous acid catalysts hydrolyze GGM at about 90°C to the monomeric sugars galactose, glucose, and mannose. In the presence of homogeneous catalysts, such as HCl, H₂SO₄, oxalic acid, and trifluoroacetic acid, the hydrolysis process shows a regular kinetic behavior, while a prominent autocatalytic effect was observed in the presence of heterogeneous cation‐exchange catalysts, Amberlyst 15 and Smopex 101. The kinetic models proposed were based on the reactivities of the nonhydrolyzed sugar units and the increase of the rate constant (for heterogeneous catalysts) as the reaction progresses and the degree of polymerization decreases. General kinetic models were derived and special cases of them were considered in detail, by deriving analytical solutions for product distributions. The kinetic parameters, describing the autocatalytic effect were determined by nonlinear regression analysis. The kinetic model described very well the overall kinetics, as well as the product distribution in the hydrolysis of water soluble GGM by homogeneous and heterogeneous catalysts. The modelling principles developed in the work can be in principle applied to hydrolysis of similar hemicelluloses as well as starch and cellulose. © 2014 American Institute of Chemical Engineers AIChE J, 60: 1066–1077, 2014     

Structure-based design of cathepsin K inhibitors containing a benzyloxy-substituted benzoyl peptidomimetic

Peptidomimetic cathepsin K inhibitors have been designed using binding models which were based on the X-ray crystal structure of an amino acid-based, active site-spanning inhibitor complexed with cathepsin K. These inhibitors, which contain a benzyloxybenzoyl group in place of a Cbz-leucine moiety, maintained good inhibitory potency relative to the amino acid-based inhibitor, and the binding models were found to be very predictive of relative inhibitor potency. The binding mode of one of the inhibitors was confirmed by X-ray crystallography, and the crystallographically determined structure is in close qualitative agreement with the initial binding model. These results strengthen the validity of a strategy involving iterative cycles of structure-based design, inhibitor synthesis and evaluation, and crystallographic structure determination for the discovery of peptidomimetic inhibitors.