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1.
Hou Kaiming Bavisotto Robert Manzi Sergio Javier Perez Eliseo Joaquín Furlong Octavio Javier Kotvis Peter Kenmoe Germaine Djuidje Tysoe Wilfred T. 《Tribology Letters》2022,70(2):1-19
Tribology Letters - Most asteroids with a diameter larger than $$\sim 300 \ {\mathrm{m}}$$ are rubble piles, i.e., consisting of more than one solid object. All asteroids are rotating but almost... 相似文献
2.
Lean practices are known to increase operational performance. Previous research has identified critical success factors for implementing lean practices. This research aims to examine the extent to which success factors are critical for various degrees of lean practice implementation. Using multiple-respondent self-assessments from 33 Dutch manufacturing small and medium-sized enterprises (SMEs), we conducted a Necessary Condition Analysis. Our findings indicated that the criticality of success factors is progression dependent. In the initial stages of the lean journey, SMEs could improve their lean practices in a bottom-up manner through local factors such as a learning focus, improvement training and support congruence. When lean practices are more advanced, some company-wide factors must be present: top management support, a shared improvement vision and a supplier link. Our findings question the universality of success factors such as strategic involvement and indicate the need for a more dynamic model of lean implementation. 相似文献
3.
Wilfred A. Abia Holly Montgomery Anne P. Nugent Christopher T. Elliott 《Comprehensive Reviews in Food Science and Food Safety》2021,20(1):501-525
Tropane alkaloids (TAs) are secondary plant metabolites derived mainly from Solanaceae plant families, with the most virulent invasive species being Datura stramonium. Datura stramonium commonly grows in cereal fields and produce TAs (e.g., hyoscyamine and scopolamine) which may accidentally contaminate cereals (and cereal-based foods) at occasionally high levels. Dietary exposure to TAs can be toxic and depending on the dose ingested can cause outcomes ranging from anticholinergic effects to acute poisoning and death. In 2019, 315 adults became ill and another five adults died in Uganda following consumption of a “Super Cereal” (a fortified blended food) that was later confirmed to be contaminated by TAs—a scenario which provoked this holistic review on TAs in foodstuffs. Thus, this article provides information on the history, development, occurrences, exposures, and human legislative and health benchmarks for TAs. It describes control strategies for reducing TA contamination of agricultural commodities and resultant health implications following consumption of TA contaminated foodstuffs. Adequate application of food safety control measures (including maximum limits) and good practices, from the start of cereal cultivation through to the final stages of manufacturing of food products can aid in the reduction of seeing toxic plants including D. stramonium in cereal fields. 相似文献
4.
The volume of industrial lignin is expected to increase with the deployment of biorefineries that convert lignocellulosic biomass to renewable chemicals and fuels. Interest in using lignin for value-added biomedical applications requires understanding of its effects on mammalian and microbial cells, which has been impaired by the toxicity of the solvents used to solubilize lignin. In this study, lignin is solvated in zwitterionic Good's buffers compatible with culture media. Up to 100 mg lignin can be solvated in 1 ml of 3-morpholinopropane-1-sulfonic acid (MOPS, pH 7.2) within 60 min at room temperature, whereby MOPS acts as a chaotropic agent. The addition of MOPS-solvated lignin to cultures of Staphylococcus aureus UAMS-1 containing a subinhibitory concentration of tunicamycin reduced growth more than 99% compared to tunicamycin alone, making lignin of interest as an antibiotic adjuvant. This effect of lignin is attributed to damage to the bacterial cell membrane. 相似文献
5.
Nurul Syahirah Mat Aron Kuan Shiong Khoo Kit Wayne Chew Pau Loke Show Wei-Hsin Chen The Hong Phong Nguyen 《国际能源研究杂志》2020,44(12):9266-9282
Biofuel has emerged as an alternative source of energy to reduce the emissions of greenhouse gases in the atmosphere and combat global warming. Biofuels are classified into first, second, third and fourth generations. Each of the biofuel generations aims to meet the global energy demand while minimizing environmental impacts. Sustainability is defined as meeting the needs of the current generations without jeopardizing the needs of future generations. The aim of sustainability is to ensure continuous growth of the economy while protecting the environment and societal needs. Thus, this paper aims to evaluate the sustainability of these four generations of biofuels. The objectives are to compare the production of biofuel, the net greenhouse gases emissions, and energy efficiency. This study is important in providing information for the policymakers and researchers in the decision-making for the future development of green energy. Each of the biofuel generations shows different benefits and drawbacks. From this study, we conclude that the first generation biofuel has the highest biofuel production and energy efficiency, but is less effective in meeting the goal of reducing the greenhouse gases emission. The third generation biofuel shows the lowest net greenhouse gases emissions, allowing the reduction of greenhouse gases in the atmosphere. However, the energy required for the processing of the third generation biofuel is higher and, this makes it less environmentally friendly as fossil fuels are used to generate electricity. The third and fourth generation feedstocks are the potential sustainable source for the future production of biofuel. However, more studies need to be done to find an alternative low cost for biofuel production while increasing energy efficiency. 相似文献
6.
Conjugation to Albumin‐Binding Molecule Tags as a Strategy to Improve Both Efficacy and Pharmacokinetic Properties of the Complement Inhibitor Compstatin 下载免费PDF全文
Dr. Yijun Huang Dr. Edimara S. Reis Dr. Patrick J. Knerr Prof. Wilfred A. van der Donk Prof. John D. Lambris 《ChemMedChem》2014,9(10):2223-2226
The compstatin family of complement inhibitors has shown promise in various immuno‐inflammatory disorders. Although recent analogues show beneficial pharmacokinetics, further extension of the plasma half‐life is expected to benefit systemic application of these peptidic inhibitors. We therefore synthesized conjugates of compstatin analogues and albumin‐binding molecules (ABM) to increase circulatory residence. Equilibrium dialysis in complement‐depleted serum showed a marked increase in plasma protein binding from <8 % to >99 % for a resulting chimera (ABM2‐Cp20). Further analysis confirmed interaction with albumin from different species, primarily via site II. Importantly, ABM2‐Cp20 bound 20‐fold stronger to its target protein C3b (KD=150 pM ) than the parent peptide. Kinetic and in silico analysis suggested that ABM2 occupies a secondary site on C3b and improves the dissociation rate via additional contacts. Addition of an ABM modifier thereby not only improved plasma protein binding but also produced the most potent compstatin analogue to date with potential implications for the treatment of systemic complement‐related diseases. 相似文献
7.
Mari Pau Balaguer Joaquin Gomez-EstacaJosep Pasqual Cerisuelo Rafael GavaraPilar Hernandez-Munoz 《LWT》2014
In this work a new methodology based on thermo-pressing a resin made from gliadins and glycerol has been developed to obtain water resistant films. The effect of processing temperature was studied on the functional properties of the films. The results of SDS-PAGE analysis of the molecular weight profiles of the resulting films were indicative of disulfide/sulfhydryl interchange reactions giving rise to the formation of intermolecular disulfide bonds between the gliadin units. These reactions augmented the degree of cross-linking of the matrix, which increased with thermo-pressing temperature, as evidenced by the residual reaction enthalpy values determined by MDSC as well as by cross-linking density values determined from tensile tests. In consequence the films produced at high temperature had better water resistance upon immersion, greater maximum tensile strength and Young's modulus values, and lower water vapor and oxygen permeabilities compared with cast films. Based on the analytical test results, thermo-pressing the resin in successive time/force steps along with a temperature of 130 °C produced gliadin films with improved properties. 相似文献
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10.
Bao Lee Phoon Chin Wei Lai Joon Ching Juan Pau‐Loke Show Wei‐Hsin Chen 《国际能源研究杂志》2019,43(10):5151-5174
With the increasing demand and depleting trend of commercial energies, it has forced the researchers all over the world to accelerate research and development in the area of renewable energy. Currently, unique and interesting features of binary compounds have gained more attention by researchers, and it became a favourite research topic among various groups of researchers around this world. It was noticed that strontium titanate (SrTiO3) consists of several extraordinary properties that can apply for miscellaneous applications especially for energy storage, fuel cells, as well as to generate hydrogen fuel via photocatalysis process. Besides that, it was noticed that SrTiO3 can be synthesised in different pathways. The method of preparation and amount of precursors can affect the surface properties of SrTiO3. Thus, this article presents a critical review on how SrTiO3 synthesis methods affect its surface morphology and the applications of SrTiO3 in various fields. 相似文献