Development of an image evaluation method for skin color distribution in facial images and its application: Aging effects and seasonal changes of facial color distribution

In this article, we present an evaluation method for the skin color distribution in the face area. Unlike previous methods that extract a specific area, our method subdivides the entire face into small regions and analyzes detailed, per-frame textures. Our evaluation method for skin color distribution is based on facial feature points and includes segmentation that takes into account the facial skeleton and muscle orientation. The use of facial feature points enables a comparison at relatively equal positions on the face without depending on the shape or size of the individual's face. Our evaluation method is versatile, and as an application, we clarified age-specific features and seasonal variations of facial color distribution. As a result of applying this evaluation method to the facial images of women aged 20 to 78 years, we confirmed that the lightness of the face decreased as age increased. In particular, the decrease in lightness was remarkable in the region along the cheekbone, from the temple to the center of the cheek. Furthermore, we analyzed the seasonal changes of melanin distribution in the face area. This showed that the melanin index increased particularly in the cheekbone area in the summer when the influence of ultraviolet rays became large. Our novel methodology and the data presented in this article will be useful in various fields, such as dermatology, cosmetics, and computer vision.     

Dynamic mechanical properties of three‐component composites (acrylic polymer/epoxy/SiO2) in the glass‐transition region

In previous studies, we reported the linear and nonlinear rheological properties of three‐component composites consisting of acrylic polymer (AP), epoxy resin (EP), and various SiO₂ contents (AP/EP/SiO₂) in the molten state. In this study, the dynamic mechanical properties of AP/EP/SiO₂ composites with different particle sizes (0.5 and 8 μm) were investigated in the glass‐transition region. The EP consisted of three kinds of EP components. The α relaxation due to the glass transition shifted to a higher temperature with an increase in the volume fraction (?) for the AP/EP/SiO₂ composites having a particle size of 0.5 μm, but the α relaxation scarcely shifted for the composite having a particle size of 8 μm as a general result. This result suggested that the SiO₂ nanoparticles that were 0.5 μm in size adsorbed a lot of the low‐glass‐transition‐temperature (T_g) component because of their large surface area. The AP/SiO₂ composites did not exhibit a shift in T_g; this indicated that the composite did not adsorb any component. The modulus in the glassy state (E′_g) exhibited a very weak &phis; dependence for the AP/EP/SiO₂ composites having particle sizes of 0.5 and 8 μm, although E′_g of the AP/SiO₂ composites increased with &phis;. The AP/EP/SiO₂ composites exhibited a peculiar dynamic mechanical behavior, although the AP/SiO₂ composites showed the behavior of general two‐component composites. Scanning electron microscopic observations indicated that some components in the EP were adsorbed on the surface of the SiO₂ particles. We concluded that the peculiar behavior of the AP/EP/SiO₂ composites was due to the selective adsorption of the EP component. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 40409.     

Terpendole E and its Derivative Inhibit STLC‐ and GSK‐1‐Resistant Eg5

Terpendole E is first natural product found to inhibit mitotic kinesin Eg5, but its inhibitory mechanism remains to be revealed. Here, we report the effects of terpendole E and 11ketopaspaline (a new natural terpendole E analogue) on the Eg5–microtubule interaction and in several Eg5 mutants. 11‐Ketopaspaline is a shunt product from terpendole E, and it shows potent inhibitory activity against the microtubule‐stimulated ATPase activity of Eg5. Unlike other Eg5 inhibitors, such as S‐trityl‐L ‐cysteine (STLC) and GSK‐1, both terpendole E and 11‐ketopaspaline only partially inhibited Eg5–microtubule interaction. Furthermore, terpendole E and 11‐ketopaspaline inhibited several Eg5 mutants that are resistant to STLC (Eg5^D130A, Eg5^L214A) or GSK‐1 (Eg5^I299F, Eg5^A356T), but with the same extent of inhibition against wild‐type Eg5. Because Eg5^D130A and Eg5^L214A show cross‐resistance to most known Eg5 inhibitors, which bind the L5 loop, these results suggest that terpendole E and its analogues have a different binding site and/or inhibitory mechanism to those for L5 loop‐binding type Eg5 inhibitors.     

Analysis of indoor PM2.5 exposure in Asian countries using time use survey

Most household fuels used in Asian countries are solid fuels such as coal and biomass (firewood, crop residue and animal dung). The particulate matter (PM), CO, NOx and SOx produced through the combustion of these fuels inside the residence for cooking and heating has an adverse impact on people's health. PM 2.5 in particular, consisting of particles with an aerodynamic diameter of 2.5 μm or less, penetrates deep into the lungs and causes respiratory system and circulatory system diseases and so on. As a result, the World Health Organization (WHO) established guideline values for this type of particulate matter in 2005. In this study, the authors focused on PM 2.5 and estimated indoor exposure concentrations for PM 2.5 in 15 Asian countries. For each environment used for cooking, eating, heating and illumination in which people are present temporarily (microenvironment), exposure concentrations were estimated for individual cohorts categorized according to sex, age and occupation status. To establish the residence time in each microenvironment for each of the cohorts, data from time use surveys conducted in individual countries were used. China had the highest estimate for average exposure concentration in microenvironment used for cooking at 427.5 μg/m³ , followed by Nepal, Laos and India at 285.2 μg/m³, 266.3 μg/m³ and 205.7 μg/m³ , respectively. The study found that, in each country, the PM2.5 exposure concentration was highest for children and unemployed women between the ages of 35 and 64. The study also found that the exposure concentration for individual cohorts in each country was greatly affected by people's use of time indoors. Because differences in individual daily life activities were reflected in the use of time and linked to an assessment of exposure to indoor air-polluting substances, the study enabled detailed assessment of the impact of exposure.     

Effect of impurity on dissolution behavior of simulated molybdenum cermet fuels

The effects of impurity Zr on dissolution behavior into nitric acid of sintered Mo pellets were investigated using simulated fuels to accumulate basic data and knowledge concerning the matrix of Mo-cermet fuels. Mo pellets containing 1– 10 mol% Zr were prepared by conventional powder metallurgical route. After characterization tests using optical microscopy (OM), X-ray diffraction and secondary electron microscopy-energy dispersive X-ray spectrometry (EDX), the sintered pellets were subjected to dissolution tests by nitric acid. The apparent dissolution rate of Mo pellets containing impurity Zr was found to be followed by the first-order chemical reaction form, which is generally known as a simple chemical reaction. The rate of dissolution of sintered Mo-cermet fuels by nitric acid was found to decrease with the increase of the amount of impurity Zr.     

Augmented reality-based block piling game with superimposed collapse prediction

Understanding what cannot be seen is difficult. Physical behavior can be explained on the basis of physical theories even if the behavior cannot be observed. Explanation of what is physically happening in the real world would become easy, however, if annotations were superimposed on the real objects. Herein, the authors demonstrate how an understanding of a physical event can be facilitated by overlapping a real-world situation with a simulation that predicts a future state. This idea is demonstrated in a game application in which a player stacks blocks into a pile until it collapses. In general, it is easy to estimate whether a block on the edge of a table will fall or not. However, it is more difficult to predict whether a stack of many blocks will collapse, and in what manner the stack will collapse. Even though previous research has demonstrated that the problem of how two-dimensionally stacked blocks collapse can be reduced to solving a sequence of convex quadratic programs, algorithms for convex quadratic programs require massive computational resources. Hence, the authors developed a fast and new algorithm based on a linear program. The proposed algorithm realizes real-time simulation based on physics that superimposes predicted collapse. The block that is predicted to fall is superimposed on the real block with a lit background projection. The system was evaluated in an experiment, and superimposed augmented reality annotation was observed to be efficient. The system was also demonstrated in game contests and received positive feedback and comments.     

Visible Light Irradiation of [60]Fullerene Causes Killing and Initiation of Transformation in Balb/3T3 Cells

Abstract

Cell transformation in vitro is a model of carcinogenesis in vivo. Two-stage transformation assay increases the sensitivity of cells to chemicals and permits detection of carcinogens acting as initiating agents. [60]Fullerene (C₆₀) was cytotoxic in BALB/3T3 cells when it was irradiated by visible light, but not without light irradiation. Under conditions when C₆₀ was cytotoxic, it acted as an initiating agent for cell transformation, but it did not act as a complete transforming agent. the initiating activity of visible-light-irradiated C₆₀ was statistically significant in a modified two-stage transformation assay including a procedure for replating cells treated by C₆₀ and light, but it was equivocal in the standard two-stage transformation assay.     

浙江金华八咏大厦

该项目位于浙江省金华市经济开发区,是浙江八咏公路工程有限公司的办公楼和酒店楼。由于位于经济开发区的入口,委托方提出要使这个项目成为标志性的建筑。预计到周边是一组皇冠式的圆顶建筑,我们设计两个简约到极致的体块。