Investigation into the therapeutic efficacy of continuous isoproterenol inhalation in relation to respiratory infections in asthmatic children

In our Department, continuous isoproterenol inhalation therapy has been conducted on status asthmatics over the last 10 years. In the present study, we investigated whether there are any differences in the therapeutic efficacy of continuous inhalation of isoproterenol in the presence or absence of respiratory infections which may induce or aggravate asthma attacks. The treatment period was significantly longer in patients with pneumonia. Further prolongation of the treatment period was noted in patients with atelectasis. However, there were no apparent differences in therapeutic efficacy according to age or the severity of attacks. These findings suggest that continuous inhalation of isoproterenol is very effective for status asthmatics if respiratory infections are thoroughly controlled.     

Measurement of the flood discharge of a small-sized river using an existing digital video recording system

In this study, a closed-circuit television (CCTV) system, installed for surveillance purposes, is utilized to measure the flow rate during a flood. The procedure to determine both the angle and scale-factor of the camera is described. Then, image analysis techniques, namely the direct visual measurement method, Large-Scale PIV (LSPIV) and Space-Time Image Velocimetry (STIV), are applied to the video images recorded by the CCTV camera. The results of these methods and the conventional float measurement are compared. In addition, the accuracy of the respective methods is discussed. A set of low-quality video images of a flood during a thunderstorm that occurred under the dark ambient conditions (midnight) is analyzed using three image-based methods. The transition of the flow rate during the event is successfully estimated.     

A new and direct preparation method of iron-based bimodal catalyst and its application in Fischer–Tropsch synthesis

A bimodal iron-based catalyst was prepared by a new one-step impregnation method. The active components were used as the “brick” to directly build the small pores inside the large pores of support, which was quite different from the previous bimodal catalysts that were prepared once more on a bimodal support. Comparing with the unimodal catalysts and conventional co-precipitated catalyst, the prepared bimodal catalyst exhibited excellent activity in Fischer–Tropsch synthesis due to the improved active metal dispersion and fastened diffusion efficiency. This preparation method is much simpler than the previous methods and can be extended to prepare various bimodal catalysts with different chemical compositions.     

Random fuzzy multi-objective linear programming: Optimization of possibilistic value at risk (pVaR)

This paper considers multiobjective linear programming problems (MOLPP) where random fuzzy variables are contained in objective functions and constraints. A new decision making model optimizing possibilistic value at risk (pVaR) is proposed by incorporating the concept of value at risk (VaR) into possibility theory. It is shown that the original MOLPPs involving random fuzzy variables are transformed into deterministic problems. An interactive algorithm is presented to derive a satisficing solution for a decision maker (DM) from among a set of Pareto optimal solutions. Each Pareto optimal solution that is a candidate of the satisficing solution is exactly obtained by using convex programming techniques. A simple numerical example is provided to show the applicability of the proposed methodology to real-world problems with multiple objectives in uncertain environments.     

Preparation and evaluation of a novel wound dressing sheet comprised of β-glucan–chitosan complex

A transparent wound dressing sheet was obtained by forming a complex between β-glucan and chitosan (CS). These materials were chosen for their biocompatible, bioabsorbable, and biodegradable properties, and they were expected to promote the therapeutic efficacy of the dressing by increasing the wound healing response. The therapeutic efficacy of the β-glucan–CS complex sheet as a wound dressing was evaluated in wounds created on the dorsal surfaces of mice. β-glucan–CS complex sheets demonstrated therapeutic efficacies comparable or superior to that of Beschitin®W, a commercial wound dressing made from CS. Additionally, the β-glucan–CS complex sheet did not dissolve during the application period, did not adhere to wounds, and was easy to remove. Cumulatively, these results indicate that β-glucan–CS complex sheets are a promising new wound dressing product.     

Experimental study of several types of ground heat exchanger using a steel pile foundation

An experimental study of several types of ground heat exchangers (GHEs) installed in a steel pile foundation, including double-tube, U-tube, and multi-tube GHEs, was carried out at Saga University. Water flows through the heat exchangers and exchanges heat to or from the ground. The performance of GHEs was investigated under actual operation in the cooling mode with flow rates of 2, 4, and 8 l/min. Temperatures of the ground and GHE tube wall were measured to find the temperature distributions according to the depth of the ground and depth of the GHE tube wall. The temperatures of the inlet and outlet of circulated water were also measured to calculate the heat exchange rate. The double-tube had the highest heat exchange rate, followed by the multi-tube and U-tube GHEs. For example, the average heat exchange rate of GHEs over 24 h of continuous operation with a flow rate of 4 l/min was 49.6 W/m for the double-tube, 34.8 W/m for the multi-tube, and 30.4 W/m for the U-tube. An increasing flow rate increased the heat exchange rate of the GHEs. The heat exchange rates increased significantly for flow rate increases from 2 to 4 l/min, but only slightly changed from 4 to 8 l/min.     

An improved synthesis of taurine- and glycine-conjugated bile acids

A simple and efficient method for the synthesis of taurine- and glycine-conjugated bile acids is described. The condensation reaction was achieved by the simple mixing of unconjugated bile acid (1.0 eq.), taurine (2.0 eq.) (or glycinate ester), diethyl phosphorocyanidate (1.2 eq.) in the presence of triethylamine at room temperature for 30-60 min. Sample clean-up was effected by the use of a prepacked Sep-Pak C18 cartridge for reversed-phase solid extraction or by direct recrystallization, yielding the desired taurine and glycine conjugates in 89-93 and 92-96% isolated yields, respectively.