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Scientometrics - The article published on 5 July 2021 is well-written and of interest. However, some improvements could be made, such as ten Tables/Figures can be shortened to highlight the focused... 相似文献
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Hui-Yung Song Yi-Ping Yang Yueh Chien Wei-Yi Lai Yi-Ying Lin Shih-Jie Chou Mong-Lien Wang Chien-Ying Wang Hsin-Bang Leu Wen-Chung Yu Chian-Shiu Chien 《International journal of molecular sciences》2021,22(5)
The late-onset type of Fabry disease (FD) with GLA IVS4 + 919G > A mutation has been shown to lead to cardiovascular dysfunctions. In order to eliminate variations in other aspects of the genetic background, we established the isogenic control of induced pluripotent stem cells (iPSCs) for the identification of the pathogenetic factors for FD phenotypes through CRISPR/Cas9 genomic editing. We adopted droplet digital PCR (ddPCR) to efficiently capture mutational events, thus enabling isolation of the corrected FD from FD-iPSCs. Both of these exhibited the characteristics of pluripotency and phenotypic plasticity, and they can be differentiated into endothelial cells (ECs). We demonstrated the phenotypic abnormalities in FD iPSC-derived ECs (FD-ECs), including intracellular Gb3 accumulation, autophagic flux impairment, and reactive oxygen species (ROS) production, and these abnormalities were rescued in isogenic control iPSC-derived ECs (corrected FD-ECs). Microarray profiling revealed that corrected FD-derived endothelial cells reversed the enrichment of genes in the pro-inflammatory pathway and validated the downregulation of NF-κB and the MAPK signaling pathway. Our findings highlighted the critical role of ECs in FD-associated vascular dysfunctions by establishing a reliable isogenic control and providing information on potential cellular targets to reduce the morbidity and mortality of FD patients with vascular complications. 相似文献
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Thien Vuong Nguyen Phi Hung Dao Tuan Anh Nguyen Viet Hung Dang Minh Nguyet Ha Thi Thuy Trang Nguyen Quoc Trung Vu Ngọc Linh Nguyen Tran Chien Dang Phuong Nguyen-Tri Dai Lam Tran Le Trong Lu 《应用聚合物科学杂志》2020,137(37):49116
This work aims to clarify the photocatalytic degradation mechanism and heat reflectance recovery performance of waterborne acrylic polymer/ZnO nanocomposite coating. To fabricate the nanocomposite coating, ZnO nanoparticles (nano-ZnO) were dispersed into acrylic polymer matrix at the various concentrations from 1 to 6% (by total weight of resin solids). The photocatalytic degradation of nanocomposite coating under ultraviolet (UV) light irradiation has been investigated by monitoring its weight loss and chemical/microstructural/morphological changes. As the topcoat layer, its heat reflectance recovery has been evaluated under UV/condensation exposure by using an artificial dirty mixture of 85 wt% nanoclay, 10 wt% silica particles (1–5 μm), 1 wt% carbon black, and 2 wt% engine oil. After 108-cycle UV/condensation exposure, infrared spectra and weight loss analysis indicated that the maximal degradation for nanocomposite coating is observed at 1 wt% nano-ZnO. On the other hand, after 96 hr of UV light exposure, the nanocomposite coating with1 wt% nano-ZnO could restore effectively the reflective index of solar-heat reflectance coating (from 58.45 to 80.78%). Finally, the photodegradation mechanism of this waterborne acrylic polymer coating has been proposed as the UV-induced formation of CC CO conjugated double bonds. As a result, its self-cleaning phenomenon can be achieved as the recovery of heat reflectance. 相似文献
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Ankur Solanki Mohammad Mahdi Tavakoli Qiang Xu Sai S. H. Dintakurti Swee Sien Lim Anirban Bagui John V. Hanna Jing Kong Tze Chien Sum 《Advanced materials (Deerfield Beach, Fla.)》2020,32(23):1907864
Heavy water or deuterium oxide (D2O) comprises deuterium, a hydrogen isotope twice the mass of hydrogen. Contrary to the disadvantages of deuterated perovskites, such as shorter recombination lifetimes and lower/invariant efficiencies, the serendipitous effect of D2O as a beneficial solvent additive for enhancing the power conversion efficiency (PCE) of triple-A cation (cesium (Cs)/methylammonium (MA)/formaminidium (FA)) perovskite solar cells from ≈19.2% (reference) to 20.8% (using 1 vol% D2O) with higher stability is reported. Ultrafast optical spectroscopy confirms passivation of trap states, increased carrier recombination lifetimes, and enhanced charge carrier diffusion lengths in the deuterated samples. Fourier transform infrared spectroscopy and solid-state NMR spectroscopy validate the N–H2 group as the preferential isotope exchange site. Furthermore, the NMR results reveal the induced alteration of the FA to MA ratio due to deuteration causes a widespread alteration to several dynamic processes that influence the photophysical properties. First-principles density functional theory calculations reveal a decrease in PbI6 phonon frequencies in the deuterated perovskite lattice. This stabilizes the PbI6 structures and weakens the electron–LO phonon (Fröhlich) coupling, yielding higher electron mobility. Importantly, these findings demonstrate that selective isotope exchange potentially opens new opportunities for tuning perovskite optoelectronic properties. 相似文献
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Nguyen Sy-Ngoc Truong-Quoc Chien Han Jang-woo Im Sunyoung Cho Maenghyo 《Journal of Mechanical Science and Technology》2021,35(10):4643-4654
Journal of Mechanical Science and Technology - Recurrent neural network (RNN)-based accelerated prediction was achieved for the long-term time-dependent behavior of viscoelastic composite laminated... 相似文献
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Journal of Intelligent Manufacturing - Probe card that serves as the carrier of die and the transmitter of information is an indispensable test interface for integrated circuit testing. The probe... 相似文献
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This study proposes an extended technology acceptance model to investigate the effects of system usability and satisfaction on users’ intention to continue using Internet banking services. Based on a survey data from 304 respondents, structural equation modeling technique was employed to validate the model. The empirical results found that users’ continuance usage intention is jointly determined by perceived usefulness, perceived compatibility and satisfaction level. The hypothesized model explains 48.2 % of the variance in continuous usage intention. Results of multi-group analysis reveal that there are different concerns and priorities between skilled and less skilled users. Given that the sample of this study is collected from a particular industry in Taiwan, the generalizability of the findings may be limited. However, the comprehensiveness and representativeness of the research sample is a major strength of this study. 相似文献