Pluronic lecithin organogel of 5-aminosalicylic acid for wound healing

5-Aminosalicylic acid (5-ASA) is an aminosalicylate anti-inflammatory drug, which is also known as mesalazine or mesalamine. Currently employed in treating inflammatory bowel disease, ulcerative colitis, inflamed anus or rectum, and maintain remission in Crohn's disease. Evidence from the researchers highlighted its significant re-epithelization in allergic asthma, aphthous, and gastric ulcerative conditions. The objective of the study was to formulate the pluronic lecithin organogel (PLO) containing 5-ASA and evaluate its wound-healing ability in a full thickness excision wound rat model. The data obtained from in silico docking studies revealed 5-ASA is having an affinity towards the transforming growth factor-beta (TGF-β) specifically towards beta1. Among various formulations prepared (F1 to F8), F1, and F6 have shown a maximum in vitro drug release with optimum pH and viscosity. From MTT assay it was found that selected PLO formulations showed no toxicity and enhanced cell proliferation in HaCaT cell lines. In vivo wound-healing studies in albino Wistar rats has revealed that PLO accelerates wound closure and reepithelization to the statistically significant level on day 3 (p?相似文献   

Investigation of dielectric properties of free standing electrospun nonwoven mat

Flexible materials with balanced dielectric as well as conductive characteristics have elucidated considerable demand in field of research where conventional dielectric or insulators can be replaced by recent advances in various electronics appliances. Our work describes the detailed analyses of dielectric properties like dielectric constant, losses, and electric modulus by means of broadband dielectric spectroscopy over frequency ranging from 0.1 Hz to 10 MHz and temperature ranging from 0 to 60 °C for poly(vinyl alcohol)‐polyaniline (PVA‐PANI) free standing electrospinning nonwoven mat. It has been contemplated that the dielectric constant was enhanced by increasing PANI concentration for complete range of frequency at room temperature. The enhanced dielectric constant value (5.14 at 0.1 Hz, 2.66 at 1 KHz, 2.58 at 10 KHz, and 2.19 at 10 MHz) was anticipated for 7 wt % loading of PANI which was attributed to the presence of dipoles and interfacial polarization enclosed by the polymers. The increased dielectric constant with PANI dosing as well as with temperature attributed to favorable interfacial polarization. Shifting of peak is noticed in the spectra of imaginary electric modulus with increase in temperature which indicates increased chain dynamics of polymers in the mat. Three‐dimensional analysis of the field emission scanning electron microscopy images was carried out by SPIP analytical software. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135, 46121.     

Identification of Natural Products as Potential Pharmacological Chaperones for Protein Misfolding Diseases

Defective protein folding and accumulation of misfolded proteins is associated with neurodegenerative, cardiovascular, secretory, and metabolic disorders. Efforts are being made to identify small-molecule modulators or structural-correctors for conformationally destabilized proteins implicated in various protein aggregation diseases. Using a metastable-reporter-based primary screen, we evaluated pharmacological chaperone activity of a diverse class of natural products. We found that a flavonoid glycoside ( C-10 , chrysoeriol-7-O-β-D-glucopyranoside) stabilizes metastable proteins, prevents its aggregation, and remodels the oligomers into protease-sensitive species. Data was corroborated with additional secondary screen with disease-specific pathogenic protein. In vitro and cell-based experiments showed that C-10 inhibits α-synuclein aggregation which is implicated in synucleinopathies-related neurodegeneration. C-10 interferes in its structural transition into β-sheeted fibrils and mitigates α-synuclein aggregation-associated cytotoxic effects. Computational modeling suggests that C-10 binds to unique sites in α-synuclein which may interfere in its aggregation amplification. These findings open an avenue for comprehensive SAR development for flavonoid glycosides as pharmacological chaperones for metastable and aggregation-prone proteins implicated in protein conformational diseases.     

(t,n): Sensor Stipulation with THAM Index for Smart Agriculture Decision-Making IoT System

Wireless Personal Communications - The rapid growth of industrial infrastructure creates ecological issues such as climate change. Field indecisiveness affects agricultural yields due to improper...     

Boron-containing bioactive glasses in bone and soft tissue engineering

Boron is considered to influence the performance of several metabolic enzymes and boron deficiency is associated with impaired growth and abnormal bone development. As such, boron is a beneficial bioactive element for animals and humans. It is also well known that boron stimulates wound healing and improves bone health. The addition of boron in different proportions to bioactive glasses has significant effects on glass structure, glass processing parameters, biodegradability, biocompatibility, bioactivity and cytotoxicity. Different compositions of bioactive glasses (BGs) containing boron, including boron-doped, borosilicate and borate glasses, are being investigated for bone and soft tissue engineering under the premise that these BGs are suitable carriers of boron, indicating controlled release of B species in the biological environment. This paper reviews up to date research and applications of borate, borosilicate, and boron doped silicate and phosphate BGs focussing on their physical, structural, degradation and biological properties for hard and soft tissue regeneration.     

Single-phase and binary phase nanogranular ferrites for magnetic hyperthermia application

The study demonstrates the performance of heating efficiency in single-phase and binary phase spinel ferrite nanosystems. Ferrimagnetic cobalt ferrite (CoFe₂O₄) (CFO) and superparamagnetic copper ferrite/copper oxide (CuFe₂O₄/CuO) (CuF) nanosystems of different particle sizes were synthesized through a microwave-assisted coprecipitation method. The heating behavior was observed in range of both field amplitudes (8-24 kA/m at 516 kHz) and frequencies (325-973 kHz at 12 kA/m). The heating efficiency was analyzed and compared by means of particle size, magnetization, effective anisotropy constant, and Néel relaxation mechanism. Indeed, the heating rate was maximized in larger ferrite particles with low effective anisotropy constant. Moreover, though the magnetization and effective anisotropy constant of single-phase CoFe₂O₄ nanoparticles were higher, the binary phase CuFe₂O₄/CuO nanosystems of similar crystallite size (28 nm) exhibited superior heating efficiency (4.21°C/s). For a field amplitude and frequency of 24 kA/m and 516 kHz, the heating rate of CuF and CFO ferrites with different crystallite sizes decreased in the order of 4.21 > 2.14 > 0.58 > 0.52°C/s for 29 nm > 25 nm > 12 nm > 15 nm, respectively. The results emphasize that binary phase ferrite nanoparticles are better thermoseeds than the single-phase ferrites for the magnetic hyperthermia application.     

Enumeration of stereo,position and chiral isomers of polysubstituted giant fullerenes: applications to C180 and C240

Abstract

We have developed combinatorial generation function methods that combine M?bius inversion and character cycle indices for the enumeration of stereo, position and chiral isomers of icosahedral giant fullerenes C₁₈₀ and C₂₄₀. Techniques are also developed for the machine perception of symmetries of especially giant fullerenes. The techniques yield, symmetries, position, stereo and chiral isomers of giant fullerenes which we illustrate with applications to icosahedral C₁₈₀(I_h), and C₂₄₀(I_h). We have obtained combinatorial tables for the isomers of C₁₈₀X_k and C₂₄₀X_k. Our results point to errors in previous computations on C₂₄₀ permutations. We have also outlined applications to NMR and ESR spectroscopy.     

Vibration of antisymmetric angle-ply composite annular plates of variable thickness

Journal of Mechanical Science and Technology - Based on first order shear deformation theory, free vibrational behaviour of antisymmetric angle-ply composite annular plate is investigated. The...