Embedding in medical images: an efficient scheme for authentication and tamper localization

Multimedia Tools and Applications - In e-healthcare applications integrity of the received information is of prime importance for ensuring the accurate diagnosis. The integrity of electronic...     

A comparative study on the effect of loading speed and surface scratches on the flexural strength of aluminosilicate glass: Annealed vs. chemically strengthened

Quasi-static and dynamic three-point-bending experiments were conducted on both annealed and chemically strengthened aluminosilicate glass scratched by different normal loads. Scratched areas were observed by optical microscope and atomic force microscope. Chemically strengthened glass shows better resistance to surface scratch. These dynamic experiments were carried out using a modified Split Hopkinson Pressure Bar (SHPB) device and a pulse-shaping technique was used to keep constant loading speed to the specimens. In tests, high-speed photography was also used to observe the failure process of the specimens. The test results showed that the flexural strength of aluminosilicate glass (AG) strongly depends on the applied loading speed. Compared with its annealed counterpart, the chemically strengthened glass (CSG) showed higher flexural strength to both static and dynamic loadings. Moreover, the three-point bending experiments were conducted on scratched AG and CSG specimens and decrease of 20–40% in flexural strength was observed. The fractography analysis showed that in dynamic loading conditions the fracture surface was not smooth and has more secondary cracks as compared to static loading.     

Micro‐morphological,environmental and phytochemical investigation of herbal medicines by using LM and SEM: A quality control tool

The use of quality control tool for authentication of Jadwar (Delphinium denudatum Wall. ex Hook.f. & Thomson), a folk herbal drug used for the treatment of different ailments, was studied. People face problems of adulteration for this drug at global, regional, national and local levels. Two different plant species are commercially marketed in the Indo‐Pak Subcontinent under the same trade name of Jadwar. One is D. denudatum Wall. ex Hook.f. & Thomson and the other is Aconitum heterophyllum Wall. ex Royle. To focus on this problem, a marketable available drug sample of Jadwar was authenticated by using basic microscopy tools (LM) and advanced chemo‐taxonomic markers. Authentication, quality and standardization of this drug was achieved using morphology, organoleptography, UV and IR analyses, scanning electron microscopy of pollen and anatomical investigations. The techniques used for authentication marked the clear difference between the studied plants. Microscopic studies, chemotaxonomic investigation and other techniques used in this project provided the basis for the authentication of this species.     

A Box of Chemistry to Inhibit the MEN1 Tumor Suppressor Gene Promoting Leukemia

Targeting protein-protein interactions (PPIs) with small-molecule inhibitors has become a hotbed of modern drug development. In this review, we describe a new class of PPI inhibitors that block menin from binding to MLL proteins. Menin is encoded by the MEN1 tumor suppressor, but acts as an essential cofactor for MLL/KMT2A-rearranged leukemias. The most promising menin-MLL inhibitors belong to the thienopyrimidine class and have recently entered phase I/II clinical trials for treating acute leukemias characterized by MLL/KMT2A translocations or NPM1 mutations. As single agents, thienopyrimidine compounds eradicate leukemia in a xenograft models of primary leukemic cells belonging to the MLL-rearranged or NPM1-mutant subtypes. These compounds are well tolerated with few or no side effects, which is remarkable given the tumor-suppressor function of menin. The menin-MLL inhibitors highlight how leukemia patients could benefit from a targeted epigenetic therapy with novel PPI inhibitors obtained by directed chemical evolution.     

Adaptive fuzzy-SIFT rule-based registration for 3D cardiac motion estimation

Applied Intelligence - 3D Speckle tracking techniques are used to quantify cardiac deformation in 3D echocardiographic images. Elastic image registration methods are successful in solving 3D...     

Buckling and dynamic instability analysis of stiffened shell panels

The static and dynamic instability characteristics of stiffened shell panels subjected to uniform in-plane harmonic edge loading are investigated in this paper. The eight-noded isoparametric degenerated shell element and a compatible three-noded curved beam element are used to model the shell panels and the stiffeners, respectively. As the usual formulation of degenerated beam element is found to overestimate the torsional rigidity, an attempt has been made to reformulate it in an efficient manner. Moreover, the new formulation for the beam element requires five degrees of freedom per node as that of shell element. The method of Hill's infinite determinant is applied to analyze the dynamic instability regions. Numerical results are presented through convergence and comparison with the published results from the literature. The effect of various parameters like shell geometry, stiffening scheme, static and dynamic load factors, stiffener size and position, and boundary conditions are considered in buckling and dynamic instability analysis of stiffened panels subjected to uniform in-plane harmonic loads along the boundaries.     

Way forward in meeting energy challenges in Pakistan

In this review the energy potential of Pakistan from hydro, coal, wind, solar and nuclear sources has been discussed. The new projects that are being commissioned on coal, wind, solar, hydel and nuclear-based technologies have also been mentioned. The review has also explored the future prospects of the country’s energy requirements. Pakistan has potential to produce 100,000?MW of electricity from Thar coal for 20 years, 56,000?MW of hydroelectricity, 150,000?MW of wind energy and ～50,000?MW from solar sources. The coal-fired power generation is expected to 11,500?MW in period 2017–2019. The country is moving in the right direction to cater its energy needs. However, there is a need to find local and foreign investment in the country to meet high energy demands in the country in future.     

Palyno‐morphological characteristics of gymnosperm flora of pakistan and its taxonomic implications with LM and SEM methods

The present study is intended to assess gymnosperms pollen flora of Pakistan using Light Microscope (LM) and Scanning Electron Microscopy (SEM) for its taxonomic significance in identification of gymnosperms. Pollens of 35 gymnosperm species (12 genera and five families) were collected from its various distributional sites of gymnosperms in Pakistan. LM and SEM were used to investigate different palyno‐morphological characteristics. Five pollen types (i.e., Inaperturate, Monolete, Monoporate, Vesiculate‐bisaccate and Polyplicate) were observed. Six In equatorial view seven types of pollens were observed, in which ten species were sub‐angular, nine species were Traingular, six species were Perprolate, three species were Rhomboidal, three species were semi‐angular, two species were rectangular and two species were prolate. While five types of pollen were observed in polar view, in which ten species were Spheroidal, nine species were Angular, eight were Interlobate, six species were Circular, two species were Elliptic. Eighteen species has rugulate and 17 species has faveolate ornamentation. Eighteen species has verrucate and 17 have gemmate type sculpturing. The data was analysed through cluster analysis. The study showed that these palyno‐morphological features have significance value in classification and identification of gymnosperms. Based on these different palyno‐morphological features, a taxonomic key was proposed for the accurate and fast identifications of gymnosperms from Pakistan.