全文获取类型
收费全文 | 312篇 |
免费 | 8篇 |
学科分类
工业技术 | 320篇 |
出版年
2021年 | 5篇 |
2019年 | 2篇 |
2018年 | 7篇 |
2017年 | 3篇 |
2016年 | 3篇 |
2015年 | 2篇 |
2014年 | 7篇 |
2013年 | 12篇 |
2012年 | 19篇 |
2011年 | 15篇 |
2010年 | 10篇 |
2009年 | 9篇 |
2008年 | 14篇 |
2007年 | 12篇 |
2006年 | 14篇 |
2005年 | 18篇 |
2004年 | 7篇 |
2003年 | 6篇 |
2002年 | 8篇 |
2001年 | 4篇 |
2000年 | 6篇 |
1999年 | 8篇 |
1998年 | 12篇 |
1997年 | 14篇 |
1996年 | 6篇 |
1995年 | 8篇 |
1994年 | 6篇 |
1993年 | 16篇 |
1992年 | 6篇 |
1991年 | 1篇 |
1990年 | 4篇 |
1989年 | 7篇 |
1988年 | 4篇 |
1987年 | 4篇 |
1986年 | 6篇 |
1985年 | 1篇 |
1984年 | 6篇 |
1983年 | 3篇 |
1982年 | 1篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1977年 | 4篇 |
1976年 | 6篇 |
1974年 | 1篇 |
1972年 | 3篇 |
1971年 | 1篇 |
1961年 | 1篇 |
1944年 | 1篇 |
排序方式: 共有320条查询结果,搜索用时 15 毫秒
1.
The status of single-case designs in counseling psychology is reviewed. Also, reasons for the underuse of these designs by counseling psychologists are discussed. Finally, potential contributions (1) in research linking process and outcome, (2) in group counseling, (3) across a variety of theoretical approaches, and (4) to evaluation and quality assurance in clinical practice are described. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
2.
Methotrexate therapy in rheumatoid arthritis: a life table review of 587 patients treated in community practice 总被引:2,自引:0,他引:2
R Buchbinder S Hall PN Sambrook GD Champion A Harkness D Lewis GO Littlejohn MH Miller PF Ryan 《Canadian Metallurgical Quarterly》1993,20(4):639-644
To determine whether methotrexate (MTX) maintains its effectiveness in rheumatoid arthritis (RA) in the setting of community based private rheumatology practice we used life table analysis to review the combined experience of a group of these practices. Of 587 patients with RA who started to take MTX, total termination rate at 70 months was 24.4% with most terminations prompted by drug toxicity. Older age (greater than 65 years) was associated with higher rates of toxicity. Treatment termination rates varied substantially between rheumatologists. We conclude that MTX therapy for RA is well tolerated and maintains effectiveness for at least 70 months. 相似文献
3.
1H dipolar decoupled 13C n.m.r. experiments with the aid of the magic angle spinning technique have been used to determine the graft content and the isomer content of the polybutadiene grafts in a graft copolymer with isotactic polypropylene. 相似文献
4.
无内胎子午线轮胎最常见的损坏是带束层边部脱层,而此损坏可能导致较大的振动,最终导致带束层和胎面剥离。要阻止带束层边部脱层,无内胎子午线轮胎必须经受住以下4种不利因素的综合作用: 相似文献
5.
The study of numerical abilities, and how they are acquired, is being used to explore the continuity between ontogenesis and environmental learning. One technique that proves useful in this exploration is the artificial simulation of numerical abilities with neural networks, using different learning paradigms to explore development. A neural network simulation of subitization, sometimes referred to as visual enumeration, and of counting, a recurrent operation, has been developed using the so-called multi-net architecture. Our numerical ability simulations use two or more neural networks combining supervised and unsupervised learning techniques to model subitization and counting. Subitization has been simulated using networks employing unsupervised self-organizing learning, the results of which agree with infant subitization experiments and are comparable with supervised neural network simulations of subitization reported in the literature. Counting has been simulated using a multi-net system of supervised static and recurrent backpropagation networks that learn their individual tasks within an unsupervised, competitive framework. The developmental profile of the counting simulation shows similarities to that of children learning to count and demonstrates how neural networks can learn how to be combined together in a process modelling development. 相似文献
6.
7.
An NMR-based metabolomic assessment of cultured cobia health in response to dietary manipulation 总被引:1,自引:0,他引:1
Commercial aquaculture feeds rely heavily on fishmeal and fish oil, which can be expensive and ecologically unsustainable. To evaluate the efficacy of reduced fishmeal diets for outgrowth, a dietary study was conducted on the finfish cobia, Rachycentron canadum. NMR-based metabolomic techniques were used to assess the effect of decreasing dietary fishmeal on the health of the cobia. Filtered serum 1H NMR spectra analysed by principal components analysis (PCA) showed cobia fed reduced fishmeal diets were metabolically different than cobia on control diets. In particular, tyrosine and betaine increased in cobia fed reduced fishmeal diets while glucose decreased, suggesting that these cobia were not receiving the necessary nutritional components required for energy and growth. The formulated control diet contributed to enriched growth and significantly elevated lactate levels suggesting enhanced gut microflora metabolism in response to dietary components. The results show that NMR-based metabolomic analysis is a useful tool in aquaculture studies. 相似文献
8.
9.
Tracey MacTavish Marie-Odile Marceau Michael Optis Kara Shaw Peter Stephenson Peter Wild 《Journal of Housing and the Built Environment》2012,27(2):207-224
First Nation (Indigenous) on-reserve housing in Canada is in crisis due to severe shortages, high reported instances of mould contamination, overcrowding and structural deficiencies. The Kitamaat reserve of the Haisla First Nation provides one example. The intent of the study reported here was to engage with the Haisla to develop a culturally appropriate, environmentally responsive and energy-efficient housing type that the Haisla could implement in the future. This work was undertaken by Marceau-Evans-Johnson Architects in collaboration with researchers at the University of Victoria. In this article, the circumstances leading to the present housing crisis are reviewed, the consultative design process with the Haisla and its outcomes are described, and the concept design solution which was co-developed for future housing is presented. 相似文献
10.
Philip J. Kuehl Tracey Boyden Dan E. Dobry Melanie Doyle-Eisele Dwayne T. Friesen Jacob D. McDonald 《Drug development and industrial pharmacy》2016,42(1):150-156
Objective: Peptide YY3–36 [PYY(3–36)] has shown efficacy in appetite suppression when dosed by injection modalities (intraperitoneal (IP)/subcutaneous). Transitioning to needle-free delivery, towards inhalation, often utilizes systemic pharmacokinetics as a key endpoint to compare different delivery methods and doses. Systemic pharmacokinetics were evaluated for PYY3–36 when delivered by IP, subcutaneous, and inhalation, the systemic pharmacokinetics were then used to select doses in an appetite suppression pharmacodynamic study.Methods: Dry-powder formulations were manufactured by spray drying and delivered to mice via nose only inhalation. The systemic plasma, lung tissue, and bronchoalveolar lavage fluid pharmacokinetics of different inhalation doses of PYY(3–36) were compared to IP and subcutaneous efficacious doses. Based on these pharmacokinetic data, inhalation doses of 70:30 PYY(3–36):Dextran T10 were evaluated in a mouse model of appetite suppression and compared to IP and subcutaneous data.Results: Inhalation pharmacokinetic studies showed that plasma exposure was similar for a 2?×?higher inhalation dose when compared to subcutaneous and IP delivery. Inhalation doses of 0.22 and 0.65?mg/kg were for efficacy studies. The results showed a dose-dependent (not dose proportional) decrease in food consumption over 4?h, which is similar to IP and subcutaneous delivery routes.Conclusions: The pharmacokinetic and pharmacodynamics results substantiate the ability of pharmacokinetic data to inform pharmacodynamics dose selection for inhalation delivery of the peptide PYY(3–36). Additionally, engineered PYY(3–36):Dextran T10 particles delivered to the respiratory tract show promise as a non-invasive therapeutic for appetite suppression. 相似文献