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Mohd-Shafie Muhammad Luqman Kadir Wan Mohd Nasir Wan Lichter Horst Khatibsyarbini Muhammad Isa Mohd Adham 《Software and Systems Modeling》2022,21(2):717-753
Software and Systems Modeling - Model-based test case generation (MB-TCG) and prioritization (MB-TCP) utilize models that represent the system under test (SUT) for test generation and... 相似文献
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Effect of Constant‐Rate Reduction on the Performance of a Ternary Cu/ZnO/Al2O3 Catalyst in Methanol Synthesis 下载免费PDF全文
A multi‐functional flow set‐up was developed for the rate‐ and temperature‐controlled reduction of copper catalysts, their application in high‐pressure methanol synthesis and the determination of the copper surface area by N2O frontal chromatography. The influence of constant‐rate reduction on the catalytic properties of a ternary Cu/ZnO/Al2O3 catalyst was investigated. The temperature during the constant‐rate reduction was found to decrease, indicating autocatalytic kinetics, but no significant catalytic effect of the milder reduction conditions was observed compared with a slow linear heating ramp. 相似文献
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We argue that the concepts of resilience in engineering science and robustness in mathematical optimisation are strongly related. Using evacuation planning as an example application, we demonstrate optimisation techniques to improve solution resilience. These include a direct modelling of the uncertainty for stochastic or robust optimisation as well as taking multiple objective functions into account. 相似文献
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Ellis N. ter Horst Nazanin Hakimzadeh Anja M. van der Laan Paul A. J. Krijnen Hans W. M. Niessen Jan J. Piek 《International journal of molecular sciences》2015,16(12):29583-29591
To diminish heart failure development after acute myocardial infarction (AMI), several preclinical studies have focused on influencing the inflammatory processes in the healing response post-AMI. The initial purpose of this healing response is to clear cell debris of the injured cardiac tissue and to eventually resolve inflammation and support scar tissue formation. This is a well-balanced reaction. However, excess inflammation can lead to infarct expansion, adverse ventricular remodeling and thereby propagate heart failure development. Different macrophage subtypes are centrally involved in both the promotion and resolution phase of inflammation. Modulation of macrophage subset polarization has been described to greatly affect the quality and outcome of healing after AMI. Therefore, it is of great interest to reveal the process of macrophage polarization to support the development of therapeutic targets. The current review summarizes (pre)clinical studies that demonstrate essential molecules involved in macrophage polarization that can be modulated and influence cardiac healing after AMI. 相似文献
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Daniel Kurz Horst Lewitschnig Juergen Pilz 《Quality and Reliability Engineering International》2021,37(6):2900-2915
Burn-in is an effective method to screen out early failures of electronic devices. Typically, this is achieved by operating the devices under accelerated stress conditions. This paper focuses on a burn-in concept where a random sample of devices is drawn out of the running production, put to burn-in, and investigated for early failures. This procedure is called burn-in study. In parallel, as long as the burn-in study is ongoing, all other produced devices are subjected to burn-in screening. In this article, new flexible sampling plans for burn-in studies are introduced. These are based on the progress of these studies and defined quality targets. Furthermore, these sampling plans enable fast burn-in time reductions and various time reduction strategies. From a statistical point of view, this requires to combine the proportion of early failures in a population with their lifetime distribution function. The new model is illustrated by case studies and simulations. It contributes to burn-in cost reductions, while controlling quality levels at the same time. 相似文献
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Sonia R. Merritt Agata A. Exner Zhenghong Lee Horst A. von Recum 《Advanced Engineering Materials》2012,14(5):B266-B278
Polymer processing via electrospinning is a cost effective and scalable method for preparing nanofibers with industrial, electrical, and biomedical applications, particularly tissue engineering and drug delivery. Characterization methods for these fibers include microscopy techniques for vitro surface morphology information, spectroscopy methods to determine in vitro chemical composition, and medical imaging tools for in vivo assessment of morphology and efficacy of implanted material. The focus of this paper is be on recent applications for electrospun nanofibers, in vitro characterization methods, and medical imaging modalities that can be used for in vivo assessment of the fibers, as well as insights in how to adapt existing techniques toward the characterization of electrospun materials. 相似文献