全文获取类型
收费全文 | 177篇 |
免费 | 8篇 |
学科分类
工业技术 | 185篇 |
出版年
2023年 | 2篇 |
2022年 | 4篇 |
2021年 | 8篇 |
2020年 | 10篇 |
2019年 | 9篇 |
2018年 | 8篇 |
2017年 | 10篇 |
2016年 | 18篇 |
2015年 | 7篇 |
2014年 | 12篇 |
2013年 | 15篇 |
2012年 | 9篇 |
2011年 | 10篇 |
2010年 | 9篇 |
2009年 | 6篇 |
2008年 | 4篇 |
2007年 | 6篇 |
2006年 | 8篇 |
2005年 | 2篇 |
2004年 | 5篇 |
2003年 | 2篇 |
2001年 | 2篇 |
2000年 | 2篇 |
1999年 | 1篇 |
1998年 | 8篇 |
1997年 | 2篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1991年 | 2篇 |
1984年 | 1篇 |
排序方式: 共有185条查询结果,搜索用时 15 毫秒
1.
Trabelsi Ali Rezgui Mohamed Ali 《The International Journal of Advanced Manufacturing Technology》2020,106(7):2829-2841
The International Journal of Advanced Manufacturing Technology - The paper discusses a generic procedure for the parameter design of product and process development using planned and non-planned... 相似文献
2.
Synthesis,Chiral Separation,Absolute Configuration Assignment,and Biological Activity of Enantiomers of Retro‐1 as Potent Inhibitors of Shiga Toxin 下载免费PDF全文
Dr. Hajer Abdelkafi Dr. Aurélien Michau Alexandra Clerget David‐Alexandre Buisson Dr. Ludger Johannes Prof. Daniel Gillet Dr. Julien Barbier Dr. Jean‐Christophe Cintrat 《ChemMedChem》2015,10(7):1153-1156
The Shiga toxin (Stx) family is composed of related protein toxins produced by the bacteria Shigella dysenteriae and certain pathogenic strains of E. coli. No effective therapies for Stx intoxication have been developed yet. However, inhibitors that act on the intracellular trafficking of these toxins may provide new options for the development of therapeutic strategies. This study reports the synthesis, chromatographic separation, and pharmacological evaluation of the two enantiomers of Retro‐1, a compound active against Stx and other such protein toxins. Retro‐1 works by inhibiting retrograde transport of these toxins inside cells. In vitro experiments proved that the configuration of the stereocenter at position 5 is not crucial for the activity of this compound. X‐ray diffraction data revealed (S)‐Retro‐1 to be slightly more active than (R)‐Retro‐1. 相似文献
3.
Raja Jelassi Hajer Khemaissia Chedliya Ghemari Maryline Raimond Catherine Souty‐Grosset Karima Nasri‐Ammar 《Microscopy research and technique》2020,83(2):148-155
The hepatopancreas of crustaceans species has been recognized as an essential target organ to assess trace elements' effects. Due to its dynamic and capability of detoxifying trace metal, this organ often indicates distinct pathological disturbances. In the present work, we intend to evaluate the bioaccumulation of trace metal in three Orchestia species (Orchestia montagui, Orchestia gammarellus, and Orchestia mediterranea) living in symmetry in the banks of Bizerte lagoon (37°13′8″N 09°55′1″E) after their exposure during 14 days to a mixture of copper and zinc, and to highlight the effect of these metals on their hepatopancreas ultrastructure using transmission electron microscopy. At the end of the experiment, results showed that the mortality and the body mass varied according to the used nominal concentrations. Significant alterations were noted in all the treatment groups. The degree of these alterations depends on the used concentration, and they are represented especially by the cells remoteness and the border lyses, the reduction of the nuclear volume, the increase in the cytoplasm density with the presence of trace metal in the nucleus as well as in the vacuole, the disorganization and the destruction of microvilli, the condensation of the majority of cellular organelles and mitochondria swelling. Through this study, Orchestia genus could be an attractive candidate for the biochemical study of trace metal toxicity in Tunisian wetlands. 相似文献
4.
5.
Jan Westerink Gideon R. Hajer Mariëtte E. G. Kranendonk Henk S. Schipper Houshang Monajemi Eric Kalkhoven Frank L. J. Visseren 《Lipids》2014,49(3):247-254
We investigated the postprandial changes in plasma levels of adipocytokines in overweight patients with metabolic syndrome after an oral fat load. After an oral fat load and during a prolonged fast, blood was drawn at 0, 2, 3, 4 and 8 h for measurement of adiponectin, adipsin, cathepsin S, chemerin, hepatic growth factor, interferon‐γ‐inducible protein‐10, leptin, macrophage chemoattractant protein‐1, macrophage migration inhibitory factor, nerve growth factor, retinol binding protein‐4, resistin, serum amyloid A1, tissue inhibitor of metalloproteinase‐1 and thrombopoietin using a microbead‐based Luminex assay. Area under the curves (AUC) were calculated and compared. Plasma adiponectin levels were higher after an oral fat load compared to fasting at t = 2 h (950 ± 513 vs. ?1,881 ± 713 ng/ml) while the plasma levels for adipsin (?9 ± 5 vs. 16 ± 5 ng/ml), chemerin (?122 ± 35 vs. 13 ± 21 ng/ml), SAA‐1 (?391 ± 213 vs. 522 ± 173 ng/ml) and TPO (?335 ± 144 vs. 622 ± 216 ng/ml) were lower after an oral fat load compared to fasting. The baseline corrected AUC for IP‐10 was higher after fat load compared to fasting (median ?116 pg h/ml; IQR ?270 to 10 vs. ?21 pg h/ml; IQR ?136 to 418 (p = 0.047). In conclusion, in overweight male subjects with the metabolic syndrome, an oral fat load is accompanied with a modest anti‐inflammatory response of adipose tissue‐derived adipocytokines. 相似文献
6.
Hajer Ben-Romdhane Enrique Alba Saoussen Krichen 《Soft Computing - A Fusion of Foundations, Methodologies and Applications》2013,17(6):1005-1017
Dynamic optimization problems (DOPs) have attracted considerable attention due to the wide range of problems they can be applied to. Lots of efforts have been expended in modeling dynamic situations, proposing algorithms, and analyzing the results (too often in a visual way). Numeric performance measurements and their statistical validation have been however barely used in the literature. Most of works in DOPs report only the best-of-generation fitness, due to its simplicity of computation. Although this measure indicates the best algorithm in terms of fitness, it does not provide any details about the actual strength and weakness of each algorithm. In this article, we conduct a comparative study among algorithms of different search modes via several performance measures to demonstrate their relative advantages. We discuss the role of using different performance measures in drawing balanced conclusions about algorithms for DOPs. 相似文献
7.
8.
Hajer Thabet Mounir Ayadi Frédéric Rotella 《International Journal of Control, Automation and Systems》2016,14(6):1520-1527
This paper is devoted to an experimental comparison between two different methods of ultra-local model control. The concept of the first proposed technique is based on the linear system resolution technique to estimate the ultra-local model parameters. The second proposed method is based on the linear adaptive observer which allows the joint estimation of state and unknown system parameters. The closed-loop control is implemented via an adaptive PID controller. In order to show the efficiency of these two control strategies, experimental validations are carried out on a two-tank system. The experimental results show the effectiveness and robustness of the proposed controllers. 相似文献
9.
10.