Efficient Flexible M-Tree Bulk Loading Using FastMap and Space-Filling Curves

Many database applications currently deal with objects in a metric space. Examples of such objects include unstructured multimedia objects and points of interest (POIs) in a road network. The M-tree is a dynamic index structure that facilitates an efficient search for objects in a metric space. Studies have been conducted on the bulk loading of large datasets in an M-tree. However, because previous algorithms involve excessive distance computations and disk accesses, they perform poorly in terms of their index construction and search capability. This study proposes two efficient M-tree bulk loading algorithms. Our algorithms minimize the number of distance computations and disk accesses using FastMap and a space-filling curve, thereby significantly improving the index construction and search performance. Our second algorithm is an extension of the first, and it incorporates a partitioning clustering technique and flexible node architecture to further improve the search performance. Through the use of various synthetic and real-world datasets, the experimental results demonstrated that our algorithms improved the index construction performance by up to three orders of magnitude and the search performance by up to 20.3 times over the previous algorithm.     

Ablative Radiotherapy Reprograms the Tumor Microenvironment of a Pancreatic Tumor in Favoring the Immune Checkpoint Blockade Therapy

The low overall survival rate of patients with pancreatic cancer has driven research to seek a new therapeutic protocol. Radiotherapy (RT) is frequently an option in the neoadjuvant or palliative settings for pancreatic cancer treatment. This study explored the effect of RT protocols on the tumor microenvironment (TME) and their consequent impact on anti-programmed cell death ligand-1 (PD-L1) therapy. Using a murine orthotopic pancreatic tumor model, UN-KC-6141, RT-disturbed TME was examined by immunohistochemical staining. The results showed that ablative RT is more effective than fractionated RT at recruiting T cells. On the other hand, fractionated RT induces more myeloid-derived suppressor cell infiltration than ablative RT. The RT-disturbed TME presents a higher perfusion rate per vessel. The increase in vessel perfusion is associated with a higher amount of anti-PD-L1 antibody being delivered to the tumor. Animal survival is increased by anti-PD-L1 therapy after ablative RT, with 67% of treated animals surviving more than 30 days after tumor inoculation compared to a median survival time of 16.5 days for the control group. Splenocytes isolated from surviving animals were specifically cytotoxic for UN-KC-6141 cells. We conclude that the ablative RT-induced TME is more suited than conventional RT-induced TME to combination therapy with immune checkpoint blockade.     

The Farmer, the Fairies, and the Computers

Using a temporary substitution of format, the author offers a fairy tale to demonstrate that we can’t expect understanding when computers take the place of humans in our interactions with service providers.     

Grid current regulation of a three-phase voltage source inverter with an LCL input filter

Many grid connected power electronic systems, such as STATCOMs, UPFCs, and distributed generation system interfaces, use a voltage source inverter (VSI) connected to the supply network through a filter. This filter, typically a series inductance, acts to reduce the switching harmonics entering the distribution network. An alternative filter is a LCL network, which can achieve reduced levels of harmonic distortion at lower switching frequencies and with less inductance, and therefore has potential benefits for higher power applications. However, systems incorporating LCL filters require more complex control strategies and are not commonly presented in literature. This paper proposes a robust strategy for regulating the grid current entering a distribution network from a three-phase VSI system connected via a LCL filter. The strategy integrates an outer loop grid current regulator with inner capacitor current regulation to stabilize the system. A synchronous frame PI current regulation strategy is used for the outer grid current control loop. Linear analysis, simulation, and experimental results are used to verify the stability of the control algorithm across a range of operating conditions. Finally, expressions for ""harmonic impedance" of the system are derived to study the effects of supply voltage distortion on the harmonic performance of the system.     

Speed superiority of scaled double-gate CMOS

Unloaded ring-oscillator simulations, performed with a generic process/physics-based compact model for double-gate (DG) MOSFETs and supplemented with model-predicted on-state currents and gate capacitances for varying supply voltages (V_DD), are used to show and explain the speed superiority of extremely scaled DG CMOS over the single-gate (e.g., bulk-Si) counterpart. The DG superiority for unloaded circuits is most substantive for low V_DD < ~1 V     

Efficient random subcloning of DNA sheared in a recirculating point-sink flow system

Based on a high-performance liquid chromatographic pump, we have built a device that allows recirculation of DNA through a 63-microm orifice with ensuing fractionation to a minimum fragment size of approximately 300 base pairs. Residence time of the DNA fragments in the converging flow created by a sudden contraction was found to be sufficiently long to allow extension of the DNA molecules into a highly extended conformation and, hence, breakage to occur at midpoint. In most instances, 30 passages sufficed to obtain a narrow size distribution, with >90% of the fragments lying within a 2-fold size distribution. The shear rate required to achieve breakage was found to be inversely proportional to the 1.0 power of the molecular weight. Compared with a restriction digest, up to 40% of all fragments could be cloned directly, with only marginal improvements in cloning efficiency having been observed upon prior end repair with Klenow, T4 polymerase or T4 polynucleotide kinase. Sequencing revealed a fairly random distribution of the fragments.     

Design criterion for low-loss optical coupler tapers

A criterion for the local taper angle of a low-loss single-mode fibre coupler is established by considering the dominant mode coupling in the coupler taper. Effects due to structure parameters, such as cladding/core thickness ratio, corecladding index difference and core separation, are investigated. It is found that the criterion for the coupler taper can be well approximated by that for the single-mode fibre taper with the same structure parameters.     

Channel capacity and state estimation for state-dependent Gaussian channels

We formulate a problem of state information transmission over a state-dependent channel with states known at the transmitter. In particular, we solve a problem of minimizing the mean-squared channel state estimation error E/spl par/S/sup n/ - S/spl circ//sup n//spl par/ for a state-dependent additive Gaussian channel Y/sup n/ = X/sup n/ + S/sup n/ + Z/sup n/ with an independent and identically distributed (i.i.d.) Gaussian state sequence S/sup n/ = (S/sub 1/, ..., S/sub n/) known at the transmitter and an unknown i.i.d. additive Gaussian noise Z/sup n/. We show that a simple technique of direct state amplification (i.e., X/sup n/ = /spl alpha/S/sup n/), where the transmitter uses its entire power budget to amplify the channel state, yields the minimum mean-squared state estimation error. This same channel can also be used to send additional independent information at the expense of a higher channel state estimation error. We characterize the optimal tradeoff between the rate R of the independent information that can be reliably transmitted and the mean-squared state estimation error D. We show that any optimal (R, D) tradeoff pair can be achieved via a simple power-sharing technique, whereby the transmitter power is appropriately allocated between pure information transmission and state amplification.